Inflammatory skin and bowel disease, neonatal, 1

This phase 2 trial tests a drug called DISC-0974 in 21 adults with inflammatory bowel disease (IBD) who also have anemia caused by inflammation. The study aims to see if the drug safely raises hemoglobin levels compared to a placebo. Participants receive injections of either DISC…

This study looks at whether taking a mix of probiotics (good bacteria) can change the gut microbiome of children and teens aged 5-18 with inflammatory bowel disease (IBD). About 40 participants will be randomly assigned to take probiotics or a placebo, then switch after a period.…

This study tests whether combining guselkumab with JAK inhibitors (upadacitinib or tofacitinib) can help people with inflammatory bowel disease that hasn't improved with other treatments. About 80 participants will receive the drug combination and be monitored for 12 and 52 weeks…

This study tests whether improving nutrition before surgery reduces complications in people with inflammatory bowel disease (IBD). About 150 adults scheduled for intestinal surgery will receive a nutrition specialist and special shakes. Researchers will track hospital stay length…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study compares a new imaging technique called Texture and Colour Enhancement Imaging (TXI) with standard white light during colonoscopy in 219 people with inflammatory bowel disease (IBD). The goal is to see if TXI finds more dysplastic (precancerous) lesions. Each patient w…

This study is testing a device called the AlgometRx Nociometer to see if it can measure inflammation in children with inflammatory bowel disease (IBD). The device checks how different nerve fibers respond, which may give doctors a clearer picture of disease activity. Researchers …

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study will analyze DNA from up to 20,000 people, including those with immune disorders and their relatives, to find genetic variants linked to conditions like atopy, autoimmunity, and primary immunodeficiency. Researchers will also study how best to return genetic results to…

This study aims to learn more about the genetics and natural history of autoinflammatory diseases, which cause repeated fevers and inflammation. Researchers will study up to 5,000 people, including patients, their relatives, and healthy volunteers. Participants provide blood and …

This study follows pregnant women with inflammatory bowel disease (IBD) and their children for up to four years after birth. Researchers want to see whether the mother's disease activity or use of immunosuppressant or biologic medications affects pregnancy outcomes or the child's…

This study follows 1,500 children newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, to understand why some respond well to treatments while others develop complications. Researchers will collect medical data and biological sa…

This study aims to better understand VEXAS syndrome and other autoinflammatory conditions by analyzing participants' DNA from blood, saliva, or skin samples. Researchers hope to discover new genetic variants that cause or contribute to these diseases. The study enrolls people of …

This study is checking how common chronic kidney disease is in children with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. Researchers will look at medical records from 600 children with IBD and compare them to children without IBD. The goal is to …

This study is looking at 50 children and adults with rare autoinflammatory diseases—conditions where the immune system causes inflammation without a clear reason. Researchers want to find what leads to a faster diagnosis, what factors are linked to these diseases, and which treat…

This study follows 450 adults who have early signs of inflammatory bowel disease (Crohn's or ulcerative colitis) found during routine colon cancer screening, but who have no symptoms yet. Researchers will collect blood, stool, and tissue samples over time to see how the disease p…

This study aims to create a large collection of blood samples and medical information from 800 people with autoimmune or inflammatory skin diseases. Researchers will use these samples to find new biomarkers and better understand what causes these conditions. The goal is to help d…

This study is looking for new genes and biological markers that cause systemic autoinflammatory diseases (SAIDs), a group of rare conditions that cause repeated fevers and inflammation. Researchers will analyze the DNA and blood of 300 patients to find disease-causing mutations a…

This early-phase study at Stanford University is testing whether the statin drug rosuvastatin changes bile acid levels and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will enroll 15 adults with PSC and inflammatory b…

The PLANET study is looking at whether tiny plastic particles in our environment can trigger gut inflammation and raise the risk of inflammatory bowel disease (IBD). Researchers will measure microplastics in stool samples from pregnant women, their healthy relatives, and people w…

This study is collecting health data, voice recordings, and biological samples from 100 IBD patients in Luxembourg (part of a larger 800-person study across Europe). Researchers hope to find patterns that can predict when a patient's treatment needs to change. The goal is to use …

This study is looking at why the immune system attacks the gut in people with celiac disease and other immune-related gut disorders. Researchers will collect blood and tissue samples from 200 adults to study immune cells and genes. The goal is to better understand what goes wrong…

This study looks at people with autoinflammatory diseases or AA amyloidosis who have genetic changes that are hard to interpret. Researchers want to understand if these changes actually cause the disease. The goal is to improve diagnosis and knowledge, not to test a new treatment…