Huntington disease

This study tested a drug called PTC518 in 159 adults with Huntington's disease to see if it is safe and can lower a harmful protein in the blood. Participants received different doses of the drug or a placebo for up to 12 months. The goal is to slow disease progression by targeti…

This study tested whether a special oil called triheptanoin can slow brain damage in people with early Huntington's disease. 100 participants took either the oil or a placebo for 6 months, followed by 6 months where everyone got the oil. The main goal was to see if it reduced bra…

This early-phase study tested a new drug called ER2001 in 8 adults with early Huntington's disease. The main goal was to check if the drug is safe and tolerable when given repeatedly through an IV. Researchers also looked at how the drug moves through the body and if it shows any…

This early phase 1 trial tested an experimental drug called ER2001 in 10 adults with early Huntington's disease. The drug was given by IV at increasing doses over 14 weeks to check safety and how the body processes it. The study also looked for early signs that the drug might aff…

This study tested whether metformin, a widely used diabetes drug, can slow the loss of thinking skills in people with Huntington's disease. Sixty adults took either metformin or a placebo for one year. Researchers measured changes in memory, attention, and other cognitive functio…

This phase 2 trial tested a stem cell therapy called Cellavita HD in 49 people with Huntington's disease. Participants received either a low dose, high dose, or placebo through IV infusions over several months. The study measured changes in motor skills to see if the treatment co…

This early-stage trial tested the safety and tolerability of an experimental drug called SAGE-718 in 6 healthy adults and a small group of people with Huntington's disease. Researchers looked for side effects and measured how the drug moves through the body. The goal was to see i…

This study aimed to develop a non-invasive prenatal test using fetal cells from a mother's blood to detect triplet repeat diseases like Huntington's disease, Fragile X syndrome, and certain types of muscular dystrophy and ataxia. Researchers enrolled 60 pregnant women at risk and…

Researchers tested an artificial intelligence program that analyzes retinal images to diagnose several nerve and brain conditions, such as optic neuropathy and brain tumors. The study used data from 693 patients with confirmed diagnoses. The goal is to create a fast triage tool f…

This study tested whether group drumming classes could improve quality of life and motor skills in people with Parkinson's or Huntington's disease. Eighteen participants took drum lessons twice a week for 12 weeks. Researchers measured changes in anxiety, depression, hand functio…

This Phase 3 study tested the long-term safety of valbenazine in 154 people with Huntington disease who have chorea (uncontrolled movements). Participants either continued from a previous study or joined new. The goal was to see if valbenazine is safe and helps control chorea ove…

This study looked at how well and how safely deutetrabenazine works for Chinese adults with Huntington's disease who have chorea (uncontrolled movements). Fifty patients took the drug as part of their normal care. The main goal was to see if chorea scores improved, especially in …

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease and their caregivers. Researchers measured movement control, emotion, quality of life, and brain changes using tests and MRI scans. The goal was to see if dance trainin…

This study tested whether using immersive virtual reality or computer-based brain training could improve thinking and memory in people with Parkinson's or Huntington's disease who have mild cognitive problems. Sixty-four participants were randomly assigned to one of three groups:…

This study tested an experimental drug called SAGE-718 to see if it could improve cognitive function (like attention and processing speed) in people with Huntington's disease. 189 participants took either the drug or a placebo daily for a period of time. The main goal was to meas…

This study tested whether SAGE-718, an experimental oral drug, can improve cognitive function in people with early Huntington's disease. 69 participants took either the drug or a placebo for 28 days. The main goal was to measure changes in thinking skills using a battery of cogni…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study looked at how the brain uses energy in people with early Huntington disease. Ten adults had an MRI scan to measure brain energy levels while resting and watching flashing lights. The goal was to understand brain metabolism, not to test a new treatment.

This study looked at brain structure and function in children, teens, and young adults (ages 6-30) who have a parent or grandparent with Huntington's disease. Researchers used MRI scans and cognitive tests to compare those who carry the gene mutation with those who do not. The go…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study aimed to translate and validate an Italian version of a tool that helps speech therapists assess swallowing difficulties (dysphagia) in people with neurodegenerative diseases like Parkinson's or ALS. Researchers tested the tool on 101 adults with such conditions to ens…

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This study looked at whether caffeine intake is linked to how Huntington's disease progresses in people who have the gene but not yet symptoms. Researchers followed 77 participants, measuring brain volume changes and thinking skills over time. The goal was to see if caffeine migh…

This completed survey study asked 131 people with or at risk for Huntington disease about their feelings, attitudes, and beliefs toward clinical research. The goal is to help researchers design better studies that are more aware of participants' needs. No treatment or drug was te…

This study looked at how brain energy changes in people with Huntington disease. Researchers used a special MRI technique to measure energy-related chemicals in the brain. The goal was to understand the disease better, not to test a treatment. About 50 adults with early-stage Hun…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…