Food allergy

This early-stage study tests two drugs together—linvoseltamab and dupilumab—in just 6 adults with severe food allergies. The goal is to see if the combination is safe and can lower IgE antibodies that trigger allergic reactions. Participants must have a history of anaphylaxis to …

This study tests whether giving children with fish allergy small, increasing doses of codfish protein (oral immunotherapy) can help them tolerate fish without reactions. 70 children aged 2 to 10 will receive either codfish or a placebo for 12 months, then be tested for desensitis…

This study tests whether giving children small daily doses of peanut or cow's milk from common foods (like cereal or whole peanuts) can help them tolerate these allergens. It involves 216 children aged 3-23 with peanut or cow's milk allergy. The goal is to see if this simple appr…

This study follows 500 people aged 6 months to 65 years with peanut allergy who are undergoing peanut oral immunotherapy. The goal is to see how many can tolerate a maintenance dose of 300 mg of peanut protein without symptoms within two years. Researchers also track changes in q…

This early-stage trial tests a new vaccine called VLP Peanut in 46 healthy adults and people with peanut allergy. The goal is to see if it is safe and tolerable, and to get an early look at whether it might reduce allergic reactions. Participants receive injections of the vaccine…

This study tests a daily skin patch called DBV712 (Viaskin Peanut) in 600 children aged 4-7 with peanut allergy. The patch delivers a tiny amount of peanut protein to train the immune system to be less sensitive. After 12 months, researchers check if children can safely eat more …

This phase 2 trial tests a new treatment called PVX108 for children and teens with peanut allergy. The treatment uses small pieces of peanut protein to help the immune system become less reactive. About 90 participants will receive either PVX108 or a placebo, and researchers will…

This study tests whether giving very small, daily doses of foods like peanut butter or boiled egg to children under 30 months can help them outgrow their food allergies. 500 kids with proven allergies will receive oral immunotherapy for one year, then be checked for tolerance. Th…

This study tests whether using a special skin barrier cream (Epiceram) twice a day, along with a steroid cream at the first sign of eczema, can prevent food allergies in babies who develop eczema by 12 weeks old. The goal is to see if this proactive skin care reduces the number o…

This study tests whether giving vitamin D supplements to healthy, breastfed infants during their first year can lower their risk of developing food allergies. Over 2,700 babies in Australia are involved, where food allergy rates are very high. Researchers will check for allergies…

This study tests a new injection called LP-003 in 6 teenagers aged 12 to 18 who have allergies like hay fever, asthma, or eczema. The main goal is to check if the drug is safe and how the body processes it. This is an early-stage trial, so it focuses on safety and drug levels rat…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study enrolls 2500 pregnant women and follows their children from before birth up to age 3 (or 6 for those who continue). Researchers collect biosamples and environmental data to identify early-life markers and biological pathways that lead to food allergy and atopic dermati…

This study follows 200 children who have tested positive for peanut allergy but avoid eating peanuts. Researchers will use a gold-standard food challenge to see which children are truly allergic and which have outgrown their allergy by age 5. The goal is to understand if avoiding…

This study aimed to see if common food allergens like milk, egg, and peanut can pass through breast milk and cause allergies in infants. Researchers planned to test breast milk samples and check babies for sensitization using skin prick and blood tests. However, the study was wit…

This study followed 221 breastfeeding mothers and their babies to see if small molecules called microRNAs in breast milk are linked to allergies, eczema, or wheezing in the first year of life. Researchers measured these molecules in milk samples and tracked babies' health. The go…

This study examines blood samples from 90 children with peanut or tree nut allergies to find immune markers that show how well oral immunotherapy is working. Researchers compare kids receiving immunotherapy, those avoiding nuts, and healthy adults. The goal is to develop better w…

This research study aims to understand why some people develop food allergies and others outgrow them. Researchers at Children's Hospital of Philadelphia will collect blood samples from 5,300 people (ages 1 month to 65 years) with and without food allergies to study immune cells …