Massive study tracks 2500 kids from womb to uncover allergy roots

NCT ID NCT04798079

Ongoing Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study enrolls 2500 pregnant women and follows their children from before birth up to age 3 (or 6 for those who continue). Researchers collect biosamples and environmental data to identify early-life markers and biological pathways that lead to food allergy and atopic dermatitis (eczema). The goal is to understand why some children develop these allergic conditions, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal early-life markers and biological pathways that predict food allergy and eczema, pointing toward future prevention strategies.
What could go wrong: This is an observational study, not testing a treatment. It may not identify clear risk markers, and findings may not lead to direct interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

allergic disease atopic eczema food allergy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLERGIC DISEASES ATOPIC DERMATITIS FOOD ALLERGY

Contacts and locations

Locations

Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Henry Ford Health System, Division of Allergy and Immunology

Detroit, Michigan, 48202, United States
Johns Hopkins Children's Center, Department of Allergy & Immunology

Baltimore, Maryland, 21287, United States
Kravis Children's Hospital, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Massachusetts General Hospital, Translational and Clinical Research Center

Boston, Massachusetts, 02114, United States
National Jewish Health

Denver, Colorado, 80206, United States
North Carolina Children's Hospital: Department of Pediatrics, Division of Allergy, Immunology and Rheumatology

Chapel Hill, North Carolina, 27599, United States
Northwestern University Feinberg School of Medicine: Dept of Dermatology

Chicago, Illinois, 60611, United States
Sean N. Parker Center for Allergy & Asthma Research at Stanford University

Stanford, California, 94040, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
University of Wisconsin School of Medicine and Public Health

Madison, Wisconsin, 53792, United States
Vanderbilt University Medical Center Department of Pediatrics Division of Pediatric Allergy, Immunology, and Pulmonary Medicine

Nashville, Tennessee, 37232, United States

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