Baby eczema cream may stop food allergies before they start

NCT ID NCT03742414

Ongoing Prevention Sponsor: Kari Nadeau, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a special skin barrier cream (Epiceram) twice a day, along with a steroid cream at the first sign of eczema, can prevent food allergies in babies who develop eczema by 12 weeks old. The goal is to see if this proactive skin care reduces the number of foods the babies become allergic to. The trial enrolled 398 infants and is currently active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tri-lipid skin barrier cream (Epiceram) and fluticasone propionate cream
What this could lead to: If it works, this could point toward a simple skin care routine that prevents food allergies in babies with eczema.
What could go wrong: This is a Phase 2 trial, so results are still early. The approach may not prevent allergies for all babies, and steroid creams have potential side effects with long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema dermatitis Eczema food allergy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS ATOPIC DERMATITIS ECZEMA ECZEMA ECZEMA, INFANTILE

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Division of Pediatric Allergy and Clinical Immunology, National Jewish Health

Denver, Colorado, 80206, United States
Sean N. Parker Center for Allergy & Asthma Research at Stanford University

Palo Alto, California, 94304, United States
University of Chicago

Chicago, Illinois, 60637, United States
• King's College London and Guy's and St. Thomas' NHS Foundation Trust, UK

London, London, United Kingdom

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