Dilated cardiomyopathy

This study will test whether sildenafil, a drug often used for erectile dysfunction, can improve heart function in children aged 1-18 with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers will measure changes in the heart's pumping ability ove…

This phase 2b trial tests AVTX-801, a D-galactose supplement, in 8 adults with PGM1-CDG, a rare genetic disorder affecting sugar metabolism. Participants currently on D-galactose will receive either the study drug or a placebo to see if it reduces disease-related events like low …

This study looks at whether an implantable defibrillator (ICD) can reduce the risk of sudden cardiac death in people with non-ischemic dilated cardiomyopathy, a type of heart muscle disease not caused by blocked arteries. Researchers will use MRI scans to find heart scarring (fib…

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This study tests whether adding melatonin (a natural sleep hormone) to standard heart failure treatment can improve heart function in women with peripartum cardiomyopathy, a rare heart condition that develops during or after pregnancy. 25 women will receive either melatonin, sele…

This early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…

This study compares two heart failure medications—sacubitril/valsartan (a newer combo drug) and captopril (an older drug)—in 70 children aged 1 month to 18 years with dilated cardiomyopathy (an enlarged, weak heart). The goal is to see which drug better improves the heart's pumpi…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study follows 10 Chinese adults who have a specific gene mutation (BAG3) linked to dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Researchers will track changes in heart function, symptoms, and biomarkers over time to better understand how the…

This study will measure hormone levels in 100 children aged 1 to 12 who have dilated cardiomyopathy, a condition where the heart is enlarged and weakened. Researchers will collect blood samples to check hormones like thyroid, cortisol, and growth factors, and compare them to heal…

This observational study will enroll 1,000 pregnant women and their fetuses to establish normal ranges for heart sounds and ECGs. The goal is to develop early warning systems for serious heart events in mothers, progression of fetal heart defects, and autoimmune-related fetal hea…

This study will check children under 18 with chronic liver disease for hidden heart problems. Doctors will use simple tests like ECG and ultrasound to look for issues such as abnormal heart rhythms or weakened heart muscle. The goal is to better understand how liver disease affec…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study watches how dilated cardiomyopathy (a weakened heart muscle) progresses in adults with specific BAG3 gene changes. Researchers will track heart function and health events over time in 30 participants. No treatment is given—the goal is to better understand the disease.…

This study is creating a registry for people with Duchenne and Becker muscular dystrophy, as well as symptomatic female carriers. The goal is to collect health data and quality-of-life information to monitor how new therapies work in real-world settings. Up to 1,500 participants …