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Corneal disorder
MONDO:0000942A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Also known as: cornea disease, cornea disease or disorder, corneal disease, corneal disorder, disease of cornea, disease or disorder of cornea, disorder of cornea
465 clinical trials for this condition and its sub-types, 46 tagged with Corneal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Corneal disorder
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Keratitis 6 trials · 298 incl. sub-types
11 sub-types
- Keratoconjunctivitis 1 trial · 260 incl. sub-types Sub-types →
- Corneal infection 6 trials · 22 incl. sub-types Sub-types →
- Corneal ulcer 16 trials · 18 incl. sub-types Sub-types →
- Corneal neovascularization 5 trials Sub-types →
- Deep keratitis 0 trials · 1 incl. sub-types Sub-types →
- Autosomal dominant keratitis 0 trials
- Filamentary keratitis 0 trials
- Macular keratitis 0 trials
- Photokeratitis 0 trials
- Scleroperikeratitis 0 trials
- Superficial keratitis 0 trials Sub-types →
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Keratoconus 61 trials
11 sub-types
- Keratoconus, stable condition 2 trials
- Acute hydrops keratoconus 0 trials
- Keratoconus 1 0 trials
- Keratoconus 2 0 trials
- Keratoconus 3 0 trials
- Keratoconus 4 0 trials
- Keratoconus 5 0 trials
- Keratoconus 6 0 trials
- Keratoconus 7 0 trials
- Keratoconus 8 0 trials
- Keratoconus 9 0 trials
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Corneal dystrophy 6 trials · 60 incl. sub-types
13 sub-types
- Corneal endothelial dystrophy 5 trials · 36 incl. sub-types Sub-types →
- Posterior corneal dystrophy 0 trials · 34 incl. sub-types Sub-types →
- Stromal corneal dystrophy 2 trials · 16 incl. sub-types Sub-types →
- Superficial corneal dystrophy 0 trials · 7 incl. sub-types Sub-types →
- Epithelial-stromal TGFBI dystrophy 1 trial · 3 incl. sub-types Sub-types →
- Chandler syndrome 2 trials
- Epithelial and subepithelial corneal dystrophy 0 trials · 2 incl. sub-types Sub-types →
- Finnish type amyloidosis 0 trials
- Judge Misch wright syndrome 0 trials
- Autosomal dominant keratitis 0 trials
- Band keratopathy 0 trials
- Corneal dystrophy, punctiform and polychromatic pre-descemet 0 trials
- Macular dystrophy, fenestrated sheen type 0 trials
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Corneal edema 17 trials · 24 incl. sub-types
4 sub-types
- Bullous keratopathy 12 trials
- Secondary corneal edema 6 trials
- Contact lens corneal edema 0 trials
- Idiopathic corneal edema 0 trials
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Cornea neoplasm 0 trials · 17 incl. sub-types
3 sub-types
- Benign neoplasm of cornea 0 trials · 17 incl. sub-types Sub-types →
- Cornea cancer 0 trials Sub-types →
- Corneal intraepithelial neoplasm 0 trials
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Keratopathy 3 trials · 15 incl. sub-types
2 sub-types
- Bullous keratopathy 12 trials
- Band keratopathy 0 trials
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Corneal ectasia 11 trials
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Limbal stem cell deficiency 10 trials
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Pellucid marginal degeneration 4 trials
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Corneal degeneration 1 trial · 2 incl. sub-types
5 sub-types
- Arcus senilis 1 trial
- Band keratopathy 0 trials
- Nodular degeneration of cornea 0 trials
- Peripheral degeneration of cornea 0 trials
- Phthisical cornea 0 trials
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Cornea plana 0 trials · 2 incl. sub-types
2 sub-types
- Cornea plana 1, autosomal dominant 2 trials
- Cornea plana 2 0 trials
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Peters anomaly 1 trial
2 sub-types
- Peters anomaly-cataract syndrome 0 trials
- Von Hippel anomaly 0 trials
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Pseudopterygium 1 trial
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Arnold stickler bourne syndrome 0 trials
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Bowman's membrane folds or rupture 0 trials
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Terrien marginal degeneration 0 trials
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X-linked corneal dermoid 0 trials
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Brittle cornea syndrome 0 trials
2 sub-types
- Brittle cornea syndrome 1 0 trials
- Brittle cornea syndrome 2 0 trials
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Corneal argyrosis 0 trials
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Corneal deposit 0 trials
3 sub-types
- Anterior corneal pigmentation 0 trials
- Posterior corneal pigmentation 0 trials
- Stromal corneal pigmentation 0 trials
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Corneal staphyloma 0 trials
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Megalocornea 0 trials
1 sub-type
- Isolated congenital megalocornea 0 trials
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Sclerocornea 0 trials
2 sub-types
- Anterior segment dysgenesis 7 0 trials
- Sclerocornea, autosomal dominant 0 trials
Most studied deeper sub-types
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New eye drops aim to speed healing after laser surgery
Disease control Recruiting nowThis Phase 2 trial tests whether Lacripep eye drops can help the cornea heal faster and more smoothly after PRK laser eye surgery. 88 active-duty military members and their dependents will receive Lacripep in one eye and a placebo in the other. The study measures corneal thicknes…
Phase 2 • Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Could urine cells heal blindness? tiny trial begins
Disease control Recruiting nowThis early study tests whether a patient's own urine-derived cells can be injected into the eye to repair damaged corneal cells. The trial enrolls just 3 people with corneal endothelial dysfunction, a condition that can cause pain and vision loss. The goal is to see if the cells …
Sponsor: Suxia Li • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Laser before eye implant may prevent glaucoma damage
Disease control Recruiting nowThis study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Plastic implants in the eye could delay corneal transplants for keratoconus patients
Disease control Recruiting nowThis study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and improve vision in people with keratoconus. The goal is to help patients who can no longer see well with glasses or contacts and may otherwise need a corneal transp…
Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New hope for down syndrome vision loss: light therapy trial launches
Disease control Recruiting nowThis Phase 3 trial tests a treatment called corneal crosslinking (CXL) for people with Down syndrome who have keratoconus, a condition where the cornea thins and bulges, blurring vision. The procedure uses vitamin B2 eye drops and ultraviolet light to strengthen the cornea. Resea…
Phase 3 • Sponsor: Woolfson Eye Institute • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Metal mesh implanted in eye could halt keratoconus
Disease control Recruiting nowThis early study tests a tiny, permanent metal mesh (nitinol) implant placed inside the cornea to stabilize the eye and improve vision in people with advanced keratoconus. The trial involves 12 adults who are not candidates for other treatments and are currently recommended for a…
Sponsor: Recornea Srl • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Eye surgeons test Tissue-Moving technique to stop pterygium return
Disease control Recruiting nowThis study tests a new surgical method for pterygium, a growth on the eye's surface. Instead of cutting the growth out completely, surgeons move it to a different spot and stitch it down, preserving healthy tissue. The goal is to see if this lowers the chance of the pterygium com…
Sponsor: Zahedan University of Medical Sciences • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Can corneal transplant patients ditch steroids after one year?
Disease control Recruiting nowThis study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …
Phase 4 • Sponsor: Maastricht University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can a Light-Based scan reveal the health of your eyes?
Diagnosis Recruiting nowThis study is testing a new imaging device called a Brillouin microscope, which uses light to measure the stiffness and water content of eye tissues. The goal is to see if this tool can help doctors better understand and diagnose eye conditions like glaucoma, dry eye, and keratoc…
Sponsor: Massachusetts General Hospital • Aim: Diagnosis
Last updated Aug 27, 2026 00:00 UTC
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Eye drops from cord blood could soothe nerve pain
Symptom relief Recruiting nowThis study tests whether eye drops made from cord blood plasma can reduce pain in people with long-term nerve-related eye pain. Twenty adults with persistent eye pain and abnormal corneal nerves will receive the drops. Researchers will measure pain levels and nerve health to see …
Sponsor: Singapore Eye Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Can better measurements sharpen vision correction?
Knowledge-focused Recruiting nowThis study looks at how accurately different measurement modes capture corneal astigmatism in people who have had cataract surgery. Researchers will compare various device settings to find the most precise way to measure the eye's curvature. The goal is to optimize measurement te…
Sponsor: Wenzhou Medical University • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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New camera-like device could help doctors see tissue health without cutting
Knowledge-focused Recruiting nowThis study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have the device used on them to see if it works safely. No treatment or medication is involved—just ob…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Light-Based eye test could spot glaucoma risk early
Knowledge-focused Recruiting nowThis pilot study is testing whether a non-contact imaging technique called Brillouin microscopy can measure corneal stiffness in people with glaucoma. Researchers will compare these measurements between patients with high-tension glaucoma, normal-tension glaucoma, and healthy con…
Sponsor: University of Maryland, Baltimore • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Which corneal transplant is best? 1,000-Patient study aims to find out
Knowledge-focused Recruiting nowThis study will compare how well patients see after three types of corneal transplants: DSAEK, UT-DSAEK, and DMEK. Researchers will follow 1,000 people who had surgery for Fuchs' endothelial corneal dystrophy or pseudophakic bullous keratopathy. They will measure vision, cell cou…
Sponsor: Centre Hospitalier Régional Metz-Thionville • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Popular diabetes drugs may ease dry eye, study suggests
Knowledge-focused Recruiting nowThis study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…
Sponsor: Attikon Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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New eye models could make LASIK safer and more predictable
Knowledge-focused Recruiting nowThis study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Just one cigarette changes your eyes in minutes, study finds
Knowledge-focused Recruiting nowThis study looks at what happens to the front part of the eye (the cornea) right after smoking a cigarette. Researchers will measure changes in corneal thickness and clarity in 90 healthy adults, comparing smokers to non-smokers. The goal is to understand if smoking causes immedi…
Sponsor: Istanbul University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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German eye registry reveals shifting trends in corneal transplants
Knowledge-focused Recruiting nowThis long-term study collects data from over 100 eye clinics in Germany to see how corneal transplant surgeries have changed since 2001. Researchers track the number of surgeries, the types of procedures used, and the reasons people need them. The goal is to understand trends, no…
Sponsor: Universität des Saarlandes • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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New eye scanner tested on 180 volunteers – no treatment involved
Knowledge-focused Recruiting nowThis study gathers eye scan images from 180 people with healthy eyes or eye diseases like glaucoma and retinal disease. The goal is to collect data using a new optical coherence tomography (OCT) device called A10900. No treatment or medication is given. The information will help …
Sponsor: Optos, PLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New 4D eye scanner debuts in operating room
Knowledge-focused Recruiting nowThis study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Brain and eye scans reveal how pain heals after cornea surgery
Knowledge-focused Recruiting nowThis study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC