Cleft lip and alveolus
MONDO:0015420Cleft lip and alveolus is a fissure type embryopathy that involves the upper lip, nasal base and alveolar ridge in variable degrees.
17 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
New device shrinks jaw gaps in cleft patients, boosts graft success
Disease control CompletedThis study tested a new, simple device to reduce the size of wide gaps in the jawbone (alveolar clefts) in 15 people aged 12-25 with repaired cleft lip and/or palate. The device slowly pulls the bone together before a bone graft, aiming to make the graft more successful. The stud…
Phase: NA • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
-
New putty could replace painful bone grafts for kids with cleft palate
Disease control CompletedThis study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well …
Phase: NA • Sponsor: UMC Utrecht • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
-
Sticky bone graft shows promise for fixing cleft defects
Disease control CompletedThis study tested a new method to repair a type of cleft palate that affects the upper gum (unilateral alveolar cleft). Ten patients received a 'sticky bone' graft combined with a special growth factor membrane. The researchers checked for inflammation, fluid leaking into the nos…
Phase: NA • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
-
New device aims to close wide gum clefts without bone grafts
Disease control CompletedThis study tested a special device placed inside the mouth to slowly pull bone across a wide gap in the gum (alveolar cleft) in 8 patients aged 7 to 20. The goal was to close the gap without needing a bone graft. Researchers measured changes in the cleft size, tooth movement, and…
Phase: NA • Sponsor: Faculty of Dental Medicine for Girls • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
-
New bone graft method shows promise for kids with cleft palate
Disease control CompletedThis study tested two different bone graft materials to repair a common birth defect called alveolar cleft (a gap in the upper jaw). Fourteen children aged 8 to 12 received either a standard graft or one mixed with a special blood product. The goal was to see which material led t…
Phase: NA • Sponsor: Beni-Suef University • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
-
Baby teeth stem cells may spare kids a second surgery for cleft palate repair
Symptom relief CompletedThis trial tests whether stem cells from children's shed baby teeth can replace the standard hip bone graft for repairing a cleft in the upper jaw. Twenty children aged 7 to 12 with cleft lip and palate will receive either the stem cell graft or a traditional bone graft from thei…
Phase: PHASE1, PHASE2 • Sponsor: Hospital Sirio-Libanes • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
-
Jaw implants aim to boost life quality after surgery
Symptom relief CompletedThis study looked at how well Global D implants work for orthognathic (jaw) surgery and whether they improve patients' quality of life. 198 people who had their first jaw surgery received these implants. Researchers measured quality of life before and after surgery using a specia…
Sponsor: Global D • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
-
Nerve blocks may cut opioid use in newborn cleft lip repair
Knowledge-focused CompletedThis completed study looked at 111 newborns who had cleft lip repair surgery. Researchers compared those who received a regional nerve block for pain relief to those who did not. The goal was to see if the nerve block reduced the amount of opioid pain medicine needed during and a…
Sponsor: Brno University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:22 UTC