Chronic cystitis

This phase 1 trial tested a new treatment called urinary microbiota transplantation (UMT) for people with cystitis glandularis, a chronic bladder condition often linked to pelvic lipomatosis. The treatment involves placing processed donor urine bacteria into the bladder. After on…

This study tested a protein called GcMAF, which is made from vitamin D-binding protein and is thought to calm the immune system. Researchers gave it to 120 adults with chronic inflammatory conditions like rheumatoid arthritis or cystitis that didn't improve with standard treatmen…

This study tests a new MRI method to see if the bladder lining is leaky in people with Interstitial Cystitis (IC), a chronic bladder pain condition. Participants receive a single MRI after contrast dyes are placed into the bladder through a catheter. The goal is to distinguish be…

This Phase 2 trial tests whether a once-daily tablet called ONO-1110 can safely reduce bladder pain in people with Hunner type interstitial cystitis, a painful bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to …

This study investigates whether acupuncture can relieve symptoms and improve quality of life in women diagnosed with treatment-resistant interstitial cystitis/bladder pain syndrome. Participants receive eight sessions of acupuncture over four weeks at specific points on the body.…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This early-stage study tested a drug called V117957 in 47 women with interstitial cystitis, a condition causing bladder pain and discomfort. Participants took either the drug or a placebo at bedtime to see if it safely reduced pain. The trial is now complete, and results will hel…

This study tested whether amitriptyline, a drug already used for depression and some chronic pain conditions, can relieve symptoms of painful bladder syndrome (PBS) in people newly diagnosed with the condition. PBS causes frequent urination and increasing pain as the bladder fill…

This study tested a gel called Cystistat (sodium hyaluronate) placed directly into the bladder to treat women with interstitial cystitis, a condition causing long-term bladder pain. Researchers tracked 74 women to see if the gel improved their symptoms and was safe. The goal was …

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy prevents UTIs in only about half of them. Researchers examined changes in bacteria in the vagina and bladder, as well as immune responses, before …