Central nervous system cancer
MONDO:0002714A malignant neoplasm involving the central nervous system
Also known as: CNS neoplasm, central nervous system tumor, central nervous system tumour, CNS cancer, CNS malignant neoplasms, CNS neoplasms, malignant, cancer of CNS, cancer of central nervous system
4377 clinical trials for this condition and its sub-types, 131 tagged with Central nervous system cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system cancer
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Malignant glioma 250 trials · 920 incl. sub-types
12 sub-types
- High grade astrocytic tumor 8 trials · 673 incl. sub-types Sub-types →
- Brain glioma 29 trials · 210 incl. sub-types Sub-types →
- Grade III glioma 44 trials · 88 incl. sub-types Sub-types →
- Oligodendroglial tumor 2 trials · 73 incl. sub-types Sub-types →
- Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types Sub-types →
- Pediatric high-grade glioma 14 trials · 16 incl. sub-types Sub-types →
- Spinal cord glioma 3 trials Sub-types →
- Granular cell cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant perineurioma 1 trial
- Isolated melanotic schwannoma 0 trials
- Neurofibroma of gallbladder 0 trials
- Neurofibroma of the heart 0 trials
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Brain cancer 682 trials · 902 incl. sub-types
9 sub-types
- Metastatic malignant neoplasm in the brain 267 trials
- Brain glioma 29 trials · 210 incl. sub-types Sub-types →
- Infratentorial cancer 4 trials · 105 incl. sub-types Sub-types →
- Supratentorial cancer 15 trials · 49 incl. sub-types Sub-types →
- Cerebral ventricle cancer 0 trials · 13 incl. sub-types Sub-types →
- Intracranial primitive neuroectodermal tumor 0 trials · 8 incl. sub-types Sub-types →
- Brain germinoma 1 trial · 4 incl. sub-types Sub-types →
- Cancer of cerebellum 1 trial
- Brain sarcoma 0 trials Sub-types →
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Primary central nervous system lymphoma 92 trials · 103 incl. sub-types
3 sub-types
- Central nervous system non-hodgkin lymphoma 1 trial · 22 incl. sub-types Sub-types →
- Cerebral lymphoma 2 trials
- Spinal cord lymphoma 0 trials
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Central nervous system sarcoma 2 trials · 74 incl. sub-types
12 sub-types
- Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types Sub-types →
- Atypical teratoid rhabdoid tumor 35 trials · 36 incl. sub-types Sub-types →
- Brain sarcoma 0 trials Sub-types →
- Central nervous system angiosarcoma 0 trials
- Central nervous system extraskeletal osteosarcoma 0 trials
- Central nervous system fibrosarcoma 0 trials
- Central nervous system leiomyosarcoma 0 trials Sub-types →
- Central nervous system rhabdomyosarcoma 0 trials
- Intracranial extraskeletal myxoid chondrosarcoma 0 trials
- Isolated melanotic schwannoma 0 trials
- Meningeal sarcoma 0 trials Sub-types →
- Spinal cord sarcoma 0 trials
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Spinal cord cancer 21 trials · 57 incl. sub-types
8 sub-types
- Metastatic malignant neoplasm in the spinal cord 38 trials
- Spinal cord glioma 3 trials Sub-types →
- Spinal cord lymphoma 0 trials
- Spinal cord melanoma 0 trials
- Spinal cord neuroblastoma 0 trials
- Spinal cord primitive neuroectodermal tumor 0 trials
- Spinal cord sarcoma 0 trials
- Spinal meninges cancer 0 trials
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Central nervous system primitive neuroectodermal neoplasm 8 trials · 24 incl. sub-types
8 sub-types
- Intracranial primitive neuroectodermal tumor 0 trials · 8 incl. sub-types Sub-types →
- Childhood central nervous system primitive neuroectodermal neoplasm 6 trials Sub-types →
- Ependymoblastoma 5 trials Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Central nervous system tumor with bcor internal tandem duplication 1 trial
- Adult central nervous system primitive neuroectodermal neoplasm 0 trials Sub-types →
- Spinal cord neuroblastoma 0 trials
- Spinal cord primitive neuroectodermal tumor 0 trials
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Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types
4 sub-types
- Esthesioneuroblastoma 9 trials
- Embryonal tumor with multilayered rosettes 8 trials
- Ependymoblastoma 5 trials Sub-types →
- Medulloepithelioma 3 trials
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Malignant tumor of meninges 0 trials · 14 incl. sub-types
10 sub-types
- Anaplastic meningioma 9 trials
- Malignant leptomeningeal tumor 3 trials · 4 incl. sub-types Sub-types →
- Cerebral meningioma 0 trials · 1 incl. sub-types Sub-types →
- Intraventricular meningioma 0 trials Sub-types →
- Lung meningioma 0 trials
- Meningeal melanomatosis 0 trials
- Meningeal sarcoma 0 trials Sub-types →
- Meninges hemangiopericytoma 0 trials
- Skin meningioma 0 trials Sub-types →
- Spinal meninges cancer 0 trials
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Malignant adrenal gland pheochromocytoma 11 trials
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Central nervous system germinoma 2 trials · 4 incl. sub-types
3 sub-types
- Brain germinoma 1 trial · 4 incl. sub-types Sub-types →
- Childhood central nervous system germinoma 1 trial Sub-types →
- Adult central nervous system germinoma 0 trials
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Central nervous system melanocytic neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Primary melanoma of the central nervous system 2 trials · 3 incl. sub-types Sub-types →
- Meningeal melanocytoma 1 trial
- Diffuse meningeal melanocytosis 0 trials
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Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types
1 sub-type
- Pineal region yolk sac tumor 1 trial
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3 sub-types
- Adult central nervous system choriocarcinoma 0 trials
- Pediatric CNS choriocarcinoma 0 trials
- Pineal region choriocarcinoma 0 trials
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2 sub-types
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Malignant carotid body paraganglioma 0 trials
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3 sub-types
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2 sub-types
Most studied deeper sub-types
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Can a Two-Drug combo beat tough childhood cancers?
Disease control CompletedThis phase 2 trial is testing whether combining two chemotherapy drugs, gemcitabine and oxaliplatin, can shrink tumors in children and adolescents with certain solid cancers that have come back or not responded to standard treatment. The study includes patients with medulloblasto…
Phase 2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Can a modified herpes virus fight recurrent brain tumors?
Disease control CompletedThis trial is testing an experimental treatment called OH2, a modified herpes simplex virus, for people with recurrent central nervous system tumors, including glioblastoma. The virus is injected into the tumor cavity after surgery to see if it can safely attack cancer cells and …
Phase 1/2 • Sponsor: Binhui Biopharmaceutical Co., Ltd. • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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New drug targets tough childhood cancers with genetic flaws
Disease control CompletedThis phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for kids with Hard-to-Treat cancers: targeted drug shows promise
Disease control CompletedThis study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors. The goal was to see if the drug could shrink or slow the growth of these…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Glow-in-the-Dark dye could help surgeons spot hidden brain tumors
Disease control CompletedThis completed Phase 1 trial tested whether a dye called indocyanine green (ICG) can make brain tumor cells glow during surgery, helping surgeons see and remove them more completely. 363 adults with brain tumors received an ICG injection before surgery, and special cameras captur…
Phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New hope for kids with rare cancers: targeted drug shows promise
Disease control CompletedThis study tested a drug called avapritinib in 29 children aged 2 to 18 with advanced solid tumors that have specific genetic changes (KIT or PDGFRA). The goal was to see if the drug is safe and can shrink or control the tumors. Participants took the drug by mouth, and researcher…
Phase 1/2 • Sponsor: Blueprint Medicines Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Immune cells injected directly into brain show promise for kids with tough tumors
Disease control CompletedThis early-stage study tested a new treatment for children and young adults with brain tumors that came back or didn't respond to standard therapy. Doctors took the patients' own immune cells, modified them to recognize a protein called EGFR on tumor cells, and injected them dire…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Glowing dye could help surgeons spot hidden brain tumor cells
Diagnosis CompletedThis study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of b…
Phase 2 • Sponsor: John Yu • Aim: Diagnosis
Last updated Jul 12, 2026 00:00 UTC
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New Gadolinium-Free MRI dye shows promise for brain scans
Diagnosis CompletedThis study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…
Phase 2 • Sponsor: Reveal Pharmaceuticals Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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Simple skin care may shield kids from cancer drug side effects
Symptom relief CompletedThis study tested a preventive skin care routine in 14 children (ages 6 months to 18 years) with brain tumors who were receiving targeted therapy (BRAF, MEK, or Pan-RAF inhibitors). The goal was to see if gentle skin care and sun protection could reduce or prevent skin reactions …
Phase 2 • Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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New study tracks Radiation's toll on Kids' brains
Knowledge-focused CompletedThis study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Large study digs into rare brain tumors to uncover clues
Knowledge-focused CompletedThis study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Researchers bank samples to unlock secrets of brain tumors
Knowledge-focused CompletedThis completed study enrolled over 1,200 people with brain or spinal cord tumors to collect medical information, blood samples, and tumor tissue. The goal was to better understand these cancers and identify promising areas for future research. Participants also received guidance …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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What stops families from enrolling in child cancer trials?
Knowledge-focused CompletedThis study uses interviews with parents and caregivers of children with central nervous system (CNS) tumors to understand what makes it hard to participate in treatment and clinical trials. It looks at practical barriers like transportation, childcare, and extra costs, as well as…
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Genetic testing could unlock new treatments for kids with brain cancer
Knowledge-focused CompletedThis study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were…
Sponsor: Masaryk University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Brain tumor patients and caregivers speak out: what they really need
Knowledge-focused CompletedThis completed study from Mayo Clinic interviewed 33 adults with brain or central nervous system (CNS) tumors, along with their caregivers, to learn about their biggest challenges and needs. The goal was to identify areas where doctors and healthcare teams can offer better suppor…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Brain tumor drug implant under the microscope: how safe is it?
Knowledge-focused CompletedThis study followed 272 people with brain tumors who received Gliadel Wafer, a chemotherapy implant placed during surgery. Researchers tracked how long patients lived and whether the tumor came back, as well as any side effects. The goal was to see how the treatment works in real…
Sponsor: Arbor Pharmaceuticals, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Proton Therapy's Long-Term effects on Kids' brains under the microscope
Knowledge-focused CompletedThis study followed 155 children with brain or central nervous system tumors who received proton radiation therapy at Massachusetts General Hospital. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment.…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Massive tumor study counts rare gene fusions
Knowledge-focused CompletedThis completed study examined tumor samples from 3820 people with advanced solid tumors to find how many have NTRK gene fusions. Researchers used genetic testing to identify these rare changes. The study did not test any treatment, but aims to guide future targeted therapy decisi…
Sponsor: Institut Bergonié • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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New radiation technique for brain tumors under the microscope
Knowledge-focused CompletedThis completed study gathered information from nearly 1,000 patients who received or were scheduled to receive HyperArc stereotactic radiosurgery, a precise radiation treatment for brain tumors. The goal was to collect data on survival and tumor control to compare HyperArc with o…
Sponsor: Varian, a Siemens Healthineers Company • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC