Aortic aneurysm

This study tests a special stent device (GORE EXCLUDER) to treat thoracoabdominal and pararenal aortic aneurysms—bulges in the main artery that can rupture. About 102 people will receive the stent through a minimally invasive procedure. Researchers will check if the device is pla…

This trial is testing a specially modified stent graft—a small mesh tube—to repair complex aortic aneurysms in people who are too high-risk for open surgery. The graft is adjusted by the physician to keep blood flowing to the kidneys and other vital organs during the procedure. T…

This study looks at how well the iCover stent works when used as a bridging stent during a procedure called fenestrated endovascular aneurysm repair (fEVAR) for complex abdominal aortic aneurysms. The goal is to see if the stent stays open and keeps the aneurysm sealed without co…

This study tracks the safety and effectiveness of the GORE® TAG® Thoracic Branch Endoprosthesis, a stent-graft device used to treat aortic arch and descending aorta conditions such as aneurysms, dissections, and transections. Researchers will follow about 155 patients who receive…

This study follows 300 people who received the GORE TAMBE device to treat complex aortic aneurysms. The goal is to confirm the device works safely and effectively outside of clinical trials. Researchers will track technical success and patient outcomes over 12 months.

This study looks at how well new, custom-made and off-the-shelf stent-grafts work for repairing complex aortic aneurysms (bulges in the main artery). About 750 people with aneurysms in the abdomen, chest, or arch will be treated using a less invasive procedure through blood vesse…

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This study provides expanded access to a new device called the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis for people with thoracoabdominal or pararenal aortic aneurysms. These are bulges in the main artery that involve branches to vital organs. The device is a stent-gra…

This study is testing a device called the E-nside stent graft system in 30 people with thoracoabdominal aortic aneurysms (a bulge in the main artery that runs through the chest and belly). The goal is to see if the device is safe and works well when placed inside the artery to re…

This study is testing a special stent graft system designed to treat thoracoabdominal aortic aneurysms, a life-threatening condition where the main artery bulges. The device is placed inside the artery to support the weakened wall and prevent rupture. Researchers are following 15…

This observational study follows 352 adults with aortic arch or descending aorta disease who receive the Thoraflex Hybrid device, sometimes with an additional RelayPro stent-graft. The goal is to evaluate safety and treatment success over 10 years, including risks like stroke, sp…

This study tests whether giving two drugs—Ulinastatin and Thymosin α1—right after emergency surgery for a torn aorta can prevent dangerous body-wide inflammation and organ failure. About 200 adults will receive the drugs, and doctors will track their organ function for a week. Th…

This trial tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm surgery. The program includes education, healthy habits, stress reduction, and social support. Ten adults having elective surgery will participate to see if the program is fe…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study looks at whether brothers, sisters, and children of people who have had an abdominal aortic aneurysm are more likely to develop one themselves. Researchers will analyze health records from nearly one million people in Sweden. The goal is to better understand how family…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study is collecting data from 400 people with abdominal aortic aneurysms to improve how doctors predict aneurysm growth. The goal is to create more personalized monitoring plans. Participants will have regular check-ups and imaging tests to track changes over time.

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …