Acute respiratory failure

This trial tests whether an automated oxygen titration system, called FreeO2, can improve oxygen weaning in patients recovering from acute hypoxemic respiratory failure. The device continuously adjusts oxygen flow based on oxygen saturation levels, potentially reducing episodes o…

This trial tests whether two existing drugs, simvastatin and baricitinib, can help people with acute respiratory distress syndrome (ARDS), a severe lung condition that causes breathing failure. Participants are grouped by biological markers into subtypes, then randomly assigned t…

This study tests whether a Bag CPAP device, added to standard oxygen, can reduce the need for breathing tubes in adults with acute hypoxemic respiratory failure. Researchers in Rwanda will randomly assign 250 patients to receive either Bag CPAP plus oxygen or oxygen alone. The ma…

This study tests whether giving steroids based on a patient's immune status can reduce deaths in severe pneumonia with respiratory failure. About 500 ICU patients will receive methylprednisolone, with doses adjusted according to their inflammatory profile. The goal is to find out…

This study tests whether giving high-flow nasal oxygen during the intubation procedure can prevent severe drops in oxygen levels in ICU patients with acute respiratory failure. 500 participants will be randomly assigned to receive either the extra oxygen or usual care. The goal i…

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This study will test whether using special distraction cards or color-changing thermochromic cards can reduce pain, fear, and anxiety in children aged 4-6 who are receiving inhaler therapy for respiratory infections. About 90 children will be randomly assigned to use one type of …

This study tests two methods to train the breathing muscles of patients with respiratory failure who are on mechanical ventilators. One method slowly increases the effort needed to trigger a breath, while the other gradually reduces the machine's support. The goal is to see which…

This study tests whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions. Participants will try both HFNC and standard oxygen therapy for two weeks each …

This study tests whether a nerve block in the neck (cervical erector spinae plane block) can reduce the feeling of shortness of breath in ICU patients with acute respiratory failure. Thirty participants will receive the block, and their breathing distress will be measured using p…

This study tests new breathing devices for people with breathing failure and high carbon dioxide levels. Standard masks can be uncomfortable, causing patients to stop treatment. The study compares a new nasal cannula and a redesigned mask to standard masks, measuring breathing ef…

This international study follows about 565 patients who need advanced breathing support, such as high-flow oxygen or a ventilator, while being transported within or between hospitals. Researchers will track what happens during these trips, including any equipment problems or inte…

This study will closely monitor 180 adults with sepsis-related acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers will take fluid samples from the lungs and blood at several time points to measure inflammation and injury markers. The goal is to …

This study looks at whether a simple, non-invasive ultrasound of the diaphragm can help predict which older adults (75+) with sudden shortness of breath will develop severe breathing failure. Researchers will measure diaphragm movement and thickness in 145 emergency patients and …

This small pilot study will test two common blood pressure medicines—nicardipine and sodium nitroprusside—in 12 patients with acute respiratory failure and high blood pressure. Researchers will use a special imaging technique called electrical impedance tomography to see how thes…

This study looks at how two sedative drugs, dexmedetomidine and remifentanil, affect breathing effort in patients with acute hypoxemic respiratory failure who are receiving high-flow nasal oxygen. Researchers will measure changes in inspiratory effort and symptoms like shortness …

This study will collect data from 624 patients in respiratory intermediate care units (RICUs) across Catalonia to build a model that predicts 30-day survival. Researchers will also test an artificial intelligence approach and create a quick app for doctors. The goal is to better …

This pilot study tests whether a simple tip sheet can help ICU doctors have better conversations with families of patients on breathing machines, especially families from different racial backgrounds. About 106 doctors and their patients' families will take part. The goal is to s…

This study looks at whether a standard step-by-step plan can help adults on high-flow oxygen therapy stop it more quickly and safely. About 2,000 patients across 8 hospitals will be involved. The goal is to see if the plan leads to more patients successfully coming off oxygen wit…

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study will compare two non-invasive breathing support methods—a face mask that pushes air in and a special nasal tube that delivers high-flow oxygen—for adults in the emergency room with dangerously low blood oxygen. About 500 participants will be randomly assigned to one me…

This pilot study will enroll 80 ICU patients with acute hypoxemic respiratory failure to compare two ventilator strategies: one that allows patients to breathe spontaneously and one that fully controls their breathing. The goal is to see if a larger trial is possible and to gathe…

This study will compare a new, shorter lung ultrasound method (using 6 checkpoints) to the standard longer method (12 checkpoints) in 20 ICU patients with acute respiratory failure. The goal is to see if the quicker method gives the same information about lung function and patien…

This study tests whether measuring jaw movements can accurately assess breathing effort in intensive care patients with acute respiratory failure. Researchers will compare jaw movement signals to the standard invasive method (esophageal pressure) in 50 adults during weaning from …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study looks at whether a chest CT scan gives important new information beyond a simple chest X-ray for ICU patients with respiratory failure. Researchers will review records of 50 patients to see if CT findings changed their treatment. The goal is to find out if some CT scan…

This study will enroll 60 adults with acute hypoxemic respiratory failure (low oxygen levels) to compare three noninvasive breathing supports: CPAP, NIV, and high-flow nasal oxygen. Researchers will use electrical impedance tomography to measure lung strain in real time. The goal…