Acute necrotizing pancreatitis

This study tests a freezing device called a cryoprobe to remove dead tissue from the pancreas in people with a serious complication of acute pancreatitis. Instead of using standard tools like forceps or snares, the cryoprobe freezes the dead tissue so it can be pulled out more ea…

This phase 3 trial tests whether taking pancreatic enzyme capsules can help people who have lost significant weight after a severe bout of pancreatitis. The study will enroll 140 adults with more than 50% pancreatic damage and at least 5% weight loss. Participants will receive ei…

This study compares early versus delayed endoscopic drainage in patients with infected necrotizing pancreatitis. About 104 adults with symptomatic, infected pancreatic fluid collections will be randomly assigned to receive the procedure within 4 weeks of disease onset or after th…

This study compares a new device called Endorotor to standard methods for removing dead pancreatic tissue in patients with severe pancreatitis. About 64 adults who need this procedure will be randomly assigned to one of two groups. The goal is to see if the Endorotor clears the t…

This trial compares removing a metal stent at 2 weeks (with a plastic stent placed) versus the usual 4 weeks (without a plastic stent) in adults with walled-off pancreatic necrosis. The goal is to see if earlier removal lowers the chance of fluid collections coming back or needin…

This study tests whether transplanting healthy gut bacteria (FMT) can reduce infections in people with moderate to severe acute pancreatitis. 80 participants will receive either FMT or a placebo through a feeding tube for five days. The goal is to see if FMT lowers the risk of se…

This study aims to find new blood-based markers that can predict or diagnose infected pancreatic necrosis (IPN) in people with severe pancreatitis. About 20% of acute pancreatitis cases develop tissue death (necrosis), and when that tissue gets infected, the risk of death rises t…

This study follows 200 adults with severe pancreatitis and sepsis who undergo open necrosectomy, a surgery to remove dead tissue. Researchers will measure how well the heart, lungs, and kidneys work over time using a standard scoring system. The goal is to understand how organ fu…

This study is a registry that will follow 1,000 people who receive standard endoscopic treatment for fluid collections caused by pancreatitis. The goal is to see how well the procedure works and what outcomes patients experience. No new treatment is being tested—this is about gat…

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study explores whether monitoring bowel sounds can help predict which patients with acute pancreatitis will develop a severe form of the disease. Researchers will enroll 352 adults across three hospitals and track their bowel sounds for at least 48 hours. The goal is to see …