Acute leukemia
MONDO:0010643A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
Also known as: acute leukaemia (disease), acute leukemia, acute leukemia (disease), leukemia, acute, X-linked, stem cell leukaemia, stem cell leukaemia (disease), stem cell leukemia, stem cell leukemia (disease)
4044 clinical trials for this condition and its sub-types, 124 tagged with Acute leukemia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Acute leukemia
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Acute lymphoblastic leukemia 508 trials · 1,319 incl. sub-types
12 sub-types
- B-cell chronic lymphocytic leukemia 509 trials · 538 incl. sub-types Sub-types →
- B-cell acute lymphoblastic leukemia 245 trials · 259 incl. sub-types Sub-types →
- Childhood acute lymphoblastic leukemia 96 trials · 136 incl. sub-types Sub-types →
- Precursor B-cell acute lymphoblastic leukemia 68 trials · 113 incl. sub-types Sub-types →
- T-cell acute lymphoblastic leukemia 75 trials · 104 incl. sub-types Sub-types →
- Acute biphenotypic leukemia 88 trials · 91 incl. sub-types Sub-types →
- Adult acute lymphoblastic leukemia 43 trials · 54 incl. sub-types Sub-types →
- Prolymphocytic leukemia 20 trials · 38 incl. sub-types Sub-types →
- Plasma cell leukemia 32 trials
- Lymphoblastic leukemia, acute, with lymphomatous features 7 trials
- Precursor T-cell acute lymphoblastic leukemia 4 trials
- Null-cell leukemia 0 trials
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Acute myeloid leukemia 1,098 trials · 1,194 incl. sub-types
78 sub-types
- Acute leukemia of ambiguous lineage 53 trials · 145 incl. sub-types Sub-types →
- Therapy related acute myeloid leukemia and myelodysplastic syndrome 87 trials · 88 incl. sub-types Sub-types →
- Acute myeloid leukemia by FAB classification 0 trials · 60 incl. sub-types Sub-types →
- Acute myeloid leukemia with multilineage dysplasia 34 trials
- Acute myeloid leukemia with mutated NPM1 25 trials
- Inherited acute myeloid leukemia 1 trial · 25 incl. sub-types Sub-types →
- Childhood acute myeloid leukemia 24 trials
- Acute myeloid leukemia, MLL gene rearrangement 23 trials
- Acute monocytic leukemia 20 trials Sub-types →
- Acute myeloid leukemia, FLT3 internal tandem duplication 18 trials
- Acute myeloid leukemia with 11q23 abnormalities 11 trials
- Acute myeloid leukemia, inv(16)(p13.1;q22) 10 trials
- Acute myeloid leukemia, t(16;16)(p13.1;q22) 10 trials
- Acute myeloid leukemia with BCR-ABL1 7 trials
- Acute myeloid leukemia with t(8;21)(q22;q22) translocation 7 trials
- Acute myeloid leukemia, del(5q31-q32) 5 trials
- Acute myeloid leukemia, t(8;21)(q22; q22.1) 5 trials
- Core binding factor acute myeloid leukemia 5 trials
- Acute myeloid leukemia with CEBPA somatic mutations 1 trial
- Acute myeloid leukemia with t(6;9)(p23;q34) 1 trial
- Acute myeloid leukemia, FLT3 tyrosine kinase domain point mutation 1 trial
- Acute myeloid leukemia, biallelic CEBPA gene mutation 1 trial
- Acute myeloid leukemia, t(15;17)(q24;q21) 1 trial
- Acute myeloid leukemia, t(v;11q23.3) 1 trial
- Acute myeloid leukemia with CBFA2T3-GLIS2 fusion 0 trials
- Acute myeloid leukemia with FUS-ERG fusion 0 trials
- Acute myeloid leukemia with MNX1-ETV6 fusion 0 trials
- Acute myeloid leukemia with NPM1 somatic mutations 0 trials
- Acute myeloid leukemia with NPM1-MLF1 fusion 0 trials
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 0 trials
- Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) 0 trials
- Acute myeloid leukemia with t(8;16)(p11;p13) translocation 0 trials
- Acute myeloid leukemia with t(9;11)(p22;q23) 0 trials
- Acute myeloid leukemia, CEBPA gene mutation 0 trials
- Acute myeloid leukemia, GATA1 gene mutation 0 trials
- Acute myeloid leukemia, KIT exon 17 mutation 0 trials
- Acute myeloid leukemia, KIT exon 8 mutation 0 trials
- Acute myeloid leukemia, KIT gene mutation 0 trials
- Acute myeloid leukemia, KRAS gene mutation 0 trials
- Acute myeloid leukemia, Monosomy 5 0 trials
- Acute myeloid leukemia, Monosomy 7 0 trials
- Acute myeloid leukemia, NRAS gene mutation 0 trials
- Acute myeloid leukemia, Non-KMT2A MLLT10 rearrangement positive 0 trials
- Acute myeloid leukemia, PTPN11 gene mutation 0 trials
- Acute myeloid leukemia, RUNX1 gene mutation 0 trials
- Acute myeloid leukemia, Trisomy 8 0 trials
- Acute myeloid leukemia, WT1 gene mutation 0 trials
- Acute myeloid leukemia, del(13q14-q21) 0 trials
- Acute myeloid leukemia, der12p 0 trials
- Acute myeloid leukemia, inv(16)(p13.3;q24.3) 0 trials
- Acute myeloid leukemia, inv(3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, loss of chromosome 17p 0 trials
- Acute myeloid leukemia, monoallelic CEBPA gene mutation 0 trials
- Acute myeloid leukemia, t(10;11)(p11.2;q23) 0 trials
- Acute myeloid leukemia, t(10;11)(p12;q23) 0 trials
- Acute myeloid leukemia, t(11;15)(p15;q35) 0 trials
- Acute myeloid leukemia, t(11;17) 0 trials
- Acute myeloid leukemia, t(11;19)(q23.3;p13.3) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13.1) 0 trials
- Acute myeloid leukemia, t(16;21)(p11;q22) 0 trials
- Acute myeloid leukemia, t(16;21)(q24;q22) 0 trials
- Acute myeloid leukemia, t(1;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(1;22) 0 trials
- Acute myeloid leukemia, t(1;22)(p13;q13) 0 trials
- Acute myeloid leukemia, t(2;12) 0 trials
- Acute myeloid leukemia, t(3;12)(q23;p12.3) 0 trials
- Acute myeloid leukemia, t(3;3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, t(3;5)(q25;q34) 0 trials
- Acute myeloid leukemia, t(4;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(5;11)(q35;p15) 0 trials
- Acute myeloid leukemia, t(6;11)(q27;q23) 0 trials
- Acute myeloid leukemia, t(6;9)(p23;q34.1) 0 trials
- Acute myeloid leukemia, t(7;12)(q36;p13) 0 trials
- Acute myeloid leukemia, t(8;16) 0 trials
- Acute myeloid leukemia, t(9;11)(p21.3;q23.3) 0 trials
- Acute myeloid leukemia, t(9;22)(q34.1;q11.2) 0 trials
- Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) 0 trials
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Leukemia, acute, X-linked 0 trials
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Subacute leukemia 0 trials
Most studied deeper sub-types
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Could dead donors provide Life-Saving bone marrow?
Disease control OngoingThis early study is testing whether bone marrow from deceased donors can be safely used for transplants in people with blood cancers like leukemia and lymphoma. Twelve patients will receive the transplant along with chemotherapy or radiation. The main goal is to see if the new ma…
Phase 1/2 • Sponsor: Ossium Health, Inc. • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Could removing certain immune cells prevent a deadly transplant complication?
Disease control OngoingThis study tests whether removing a specific type of immune cell (naive T cells) from donor stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body after a stem cell tr…
Phase 2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Lower drug dose after transplant may cut infections without losing protection
Disease control OngoingThis study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…
Phase 2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New stem cell therapy aims to tame transplant complications
Disease control OngoingThis study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. It uses a special mix of stem cells and immune cells from a donor to help the body accept the transplant while reducing serious side effects like graft-versus-host disease. The go…
Phase 1 • Sponsor: Orca Biosystems, Inc. • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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New radiation technique aims to protect lungs during stem cell transplants
Disease control OngoingThis early-phase study tests a new way to deliver total body radiation before a stem cell transplant for people with acute leukemia or myelodysplastic syndrome. The goal is to reduce radiation to the lungs to prevent serious lung damage. Twenty participants will receive intensity…
Phase 1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Radioactive therapy targets stubborn leukemia in early trial
Disease control OngoingThis study tests a new radioactive drug called [177Lu]Lu-PentixaTher in people with acute leukemia that has come back or not responded to standard treatments. The drug seeks out and delivers radiation directly to leukemia cells that have a specific marker (CXCR4). The main goals …
Phase 1/2 • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New transplant approach aims to tame Graft-Versus-Host disease
Disease control OngoingThis early-phase study tests a stem cell transplant method for people with advanced blood cancers like leukemia. Instead of using strong drugs to prevent complications, doctors give specially selected immune cells (regulatory T-cells) along with regular T-cells to help the body a…
Phase 1 • Sponsor: Stanford University • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Can a pill keep blood cancer away after transplant?
Disease control OngoingThis phase 1 trial tests whether the oral drug Inqovi (decitabine/cedazuridine) can help prevent myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) from returning after a stem cell transplant. About 22 adults who have had a reduced-intensity transplant will …
Phase 1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Experimental cocktail aims to beat back tough leukemia
Disease control OngoingThis phase 2 trial tests a combination of chidamide, azacytidine, and a chemotherapy regimen (HAG) in 21 adults with acute myeloid leukemia that has come back or not responded to treatment. The goal is to see how well the combo works and what side effects it causes. Participants …
Phase 2 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New hope for blood cancer patients: using mismatched donors for transplants
Disease control OngoingThis study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to help prevent the donor cells from attacking the patient's body. The goal is to see if th…
Phase 2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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New stem cell mix aims to make transplants safer for blood cancer patients
Disease control OngoingThis phase 3 trial tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. Orca-T is a special mix of stem cells and immune cells from a matched donor, designed to reduce a serious side effect called graft-versus-host disease. The study compares …
Phase 3 • Sponsor: Orca Biosystems, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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New pill shows promise for tough leukemias in early trial
Disease control OngoingThis study tests an oral drug called BN104 in adults and adolescents with acute leukemia that has come back or not responded to treatment. The drug targets specific genetic changes (KMT2A rearrangement or NPM1 mutation) that drive the cancer. The trial aims to check safety, how t…
Phase 1/2 • Sponsor: Institut de Recherches Internationales Servier (I.R.I.S.) • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Blood cancer transplant trial using banked donor marrow pulled before start
Disease control CancelledThis Phase 1 trial aimed to test whether bone marrow from deceased, mismatched unrelated donors could be safely used for transplants in patients with blood cancers like leukemia. The approach used stored (cryopreserved) marrow along with drugs to prevent rejection. However, the s…
Phase 1 • Sponsor: Ossium Health, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Could a cancer drug shield young transplant patients from a deadly complication?
Disease control OngoingThis study tests whether adding the drug vorinostat to standard care can prevent graft-versus-host disease (GVHD) in children, adolescents, and young adults receiving a bone marrow or blood stem cell transplant for blood cancers. Researchers are first finding the best dose of vor…
Phase 1/2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New drug shows promise for rare childhood cancers
Disease control OngoingThis study tests a drug called larotrectinib in children and young adults (up to age 30) with certain cancers that have a specific genetic change called a TRK fusion. The goal is to see if the drug can shrink solid tumors or control leukemia that has returned. The drug works by b…
Phase 2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New drug may make stem cell transplants safer for older patients
Disease control OngoingThis early-phase trial tests whether the drug itacitinib can prevent cytokine release syndrome (a severe inflammatory reaction) after a mini stem cell transplant in people aged 60 and older with certain blood cancers. The study also aims to see if itacitinib allows doctors to use…
Phase 1 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Jun 26, 2026 18:40 UTC
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Pen and paper: a new tool for cancer recovery?
Symptom relief OngoingThis study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. About 192 people who finished cancer treatment in the last 5 years will take part. They will write and report how they feel, and researchers will track an…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Could early comfort care change End-of-Life for blood cancer patients?
Symptom relief OngoingThis study looks at whether starting palliative care early can help adults with aggressive leukemias or myelodysplastic syndrome (MDS) have a better end-of-life experience. Researchers will compare where patients die (home, hospice, or hospital) and how often they need hospital c…
Sponsor: University of Virginia • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Parent training may boost school success for latino kids with cancer
Symptom relief OngoingThis study tests whether a high-intensity parenting program can improve learning and school functioning in Latino children being treated for leukemia or lymphoma. About 214 parents and children will take part. Parents in the high-intensity group will receive extra training in ski…
Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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New brain scan may predict chemo brain in young leukemia patients
Knowledge-focused PausedThis study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …
Sponsor: Case Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Could muscle loss predict blood cancer outcomes?
Knowledge-focused OngoingThis study is investigating how common muscle loss, known as sarcopenia, is in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will measure body composition using DXA scans and track hospital stays, disease progression, and survival. The goal is to see…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Digital tools aim to close learning gaps for young cancer survivors
Knowledge-focused OngoingThis study tests whether a special website and video coaching for parents can help children aged 6-12 who had leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking due to treat…
Sponsor: City of Hope Medical Center • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Massive study aims to uncover hidden triggers of blood cancers
Knowledge-focused By invitation onlyThis study is collecting blood, bone marrow, and tissue samples from 5,000 people with blood cancers like leukemia and lymphoma. Researchers will analyze the samples to find genetic abnormalities that cause cancer cells to grow. The goal is to understand why these cancers develop…
Sponsor: OHSU Knight Cancer Institute • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Could a common Weight-Loss drug shield the brain? early trial launches
Knowledge-focused PausedThis pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…
Early phase 1 • Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Scientists hunt for genetic clues in childhood leukemia
Knowledge-focused OngoingThis study looks at genetic changes in cancer stem cells from children and young adults with acute leukemia. Researchers will analyze bone marrow or blood samples to find gene patterns that may drive the disease. The goal is to better understand leukemia and potentially discover …
Sponsor: Sanford Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC