Experimental cocktail aims to beat back tough leukemia
NCT ID NCT05029141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a combination of chidamide, azacytidine, and a chemotherapy regimen (HAG) in 21 adults with acute myeloid leukemia that has come back or not responded to treatment. The goal is to see how well the combo works and what side effects it causes. Participants receive two 28-day cycles of the drug regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chidamide, azacytidine, cytarabine, homoharringtonine, and granulocyte colony-stimulating factor
What this could lead to
If successful, this combination could offer a new treatment option for patients with hard-to-treat acute myeloid leukemia.
What could go wrong
This is a small, early-phase trial with only 21 participants, so results may not apply to everyone. The drugs can cause serious side effects like low blood counts and infection.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The First Affliated Hospital of Soochow University
Suzhou, Jiangsu, 215006, China