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116076 trials found · Page 4931 of 5804
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Heart failure patients: does stress make it worse?
Knowledge-focused Recruiting nowThe purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.
Phase: NA • Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Thumb arthritis pain relief: steroid shot vs. placebo
Symptom relief CompletedThis randomized clinical trial (RCT) will evaluate 6-month outcomes following intra-articular injections for arthritis of the thumb carpometacarpal (CMC) joint by comparing corticosteroid plus local anesthetic versus saline (placebo) plus local anesthetic.
Phase: PHASE4 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Epilepsy surgery study tracks Patients' mental health over time
Knowledge-focused Recruiting nowThe aim of the study is to describe the socio-demographic, clinical, psychological, and psychiatric characteristics of patients with drug-resistant focal epilepsy eligible for epilepsy surgery and any changes in these parameters over time after surgery. Additionally, the study se…
Phase: NA • Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Virtual reality headsets ease pain during knee treatment, study finds
Symptom relief CompletedThe study team aims to investigate whether implementing virtual reality therapy (VRT) during Genicular nerve radiofrequency ablation (GNRFA) procedure will provide better alleviation of procedural pain and augmented satisfaction for patients.
Phase: NA • Sponsor: University of California, Irvine • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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New toolkit aims to close colonoscopy gap in rural illinois
Knowledge-focused CompletedLess than half of all positive fecal immunochemical testing (FIT)s are followed-up by colonoscopy, thus limiting the full potential of colorectal cancer (CRC) screening to reduce mortality. Given the need for coordination in order to achieve high rates of follow-up, multilevel ap…
Phase: NA • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Can we predict which preemies will need a breathing tube?
Knowledge-focused CompletedNon-invasive respiratory support methods have been widely used in premature babies with respiratory distress syndrome (RDS) which has changed the basic management of premature babies in the early period. According to the 2019 European Guidelines on RDS management, early nasal CPA…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Could your diet affect transplant complications? new study investigates
Knowledge-focused Recruiting nowWith the stem cell transplanting increasing, patients which effected with "GVHD" were also increased. To evaluation the relationship between "FODMAPs" and "GVHD", Bone marrow transplant patients were recruited.
Sponsor: The First Affiliated Hospital of Soochow University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New dialogue tool aims to boost Well-Being in veterans with PTSD
Symptom relief CompletedThe primary outcome is quality of life, with secondary outcomes including PTSD symptoms, and psychosocial functioning. We hypothesise that a low-dose intervention based on empowerment and self-directed goal setting will lead to (a) measurable improvements in veterans' quality of …
Phase: NA • Sponsor: Reinier van Arkel • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Bacteria's secret hideout: inside bone infection cells
Knowledge-focused CompletedDifferent mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Heart ultrasound in crisis: does it save lives?
Knowledge-focused Recruiting nowThe general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this st…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Can PET scans better predict lymphoma outcomes?
Knowledge-focused OngoingThe general aim of the present study is to assess the role of PET for the staging and for the assessment of response and outcome prediction in Marginal Zone Lymphoma (MZL). This study will be conducted as a multicenter retrospective analysis of MZL for whom PET scan are available…
Sponsor: International Extranodal Lymphoma Study Group (IELSG) • Aim: Knowledge-focused
Last updated Jul 26, 2026 00:00 UTC
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New study aims to fill gap in sexual health support for breast cancer patients
Knowledge-focused CompletedIn the present study, we propose a mixed methods approach to characterize and address the sexual health needs among women with breast cancer at the time of diagnosis and throughout treatment.
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Thousands with blood diseases to be tracked in massive chinese registry
Knowledge-focused Recruiting nowBackground Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China. There is a lack of comprehensive and large-scale prospec…
Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Autism study: kids may pick up words just by listening in
Knowledge-focused CompletedThe goal of this research is to explore abilities to learn word meanings from overheard conversations in children with ASD (and, as a control, typically developing children). Specific Aim 2 (Experiment 2): Determine whether children with ASD can learn from addressed and overhear…
Phase: NA • Sponsor: New York University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Foot rubs may tune up your diaphragm, scientists say
Knowledge-focused CompletedDiaphragm dysfunction, are refractory to drug therapy. This encourage investigators to explore new non-drug therapeutic paths, such as plantar reflexology (RP). The investigators proposed a comparison of the evolution of different parameters, quantitative and qualitative, to iden…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Hidden amyloid in heart valves: a new clue in aortic stenosis?
Knowledge-focused Recruiting nowCardiac amyloidosis is a restrictive cardiomyopathy with a potentially severe prognosis that can be life-threatening. It is linked in the vast majority of cases to a light chain deposition of immunoglobulin or transthyretin. Although myocardial involvement is predominant, other l…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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New imaging study peers inside rare heart valve condition
Knowledge-focused Recruiting nowThe study involves annual 4D CTA imaging of the bicuspid aortic valve for a period of 5 years. CTA is often standard of care for BAV patients, but patients in this study will receive a higher radiation dose with a 4D imaging protocol. There may also be patients enrolled in the st…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Pregnancy struggles of women with eating disorders explored in new study
Knowledge-focused CompletedWomen with the eating disorder bulimia nervosa (BN) have been found to have a higher risk of unplanned pregnancies than healthy women, and experience greater miscarriage, premature birth, birth complications, and postpartum depression. Other studies have found that women with eat…
Sponsor: Ostfold University College • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:42 UTC
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Can social training help veterans with psychosis connect better?
Symptom relief CompletedPsychotic spectrum disorders (PSD) are associated with poor social function. By doing this study, the investigators hope to learn which of two different types of 2-month long training courses is more effective in improving day-to-day interactions and quality of life.
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Brain scans reveal why people with BDD see themselves differently
Knowledge-focused Recruiting nowA core symptom of body dysmorphic disorder (BDD) is perceptual distortions for appearance, which contributes to poor insight and delusionality, limits engagement in treatment, and puts individuals at risk for relapse. Results from this study will provide a comprehensive mechanist…
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC