Could a simple pill stop depression after a broken bone?
NCT ID NCT05851898
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether giving the antidepressant duloxetine to adults aged 65 and older right after a broken leg can prevent depression. One hundred participants will take duloxetine daily for a year and be screened monthly for depressive symptoms. The main goal is to see if this approach is practical and acceptable, not yet to prove it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Duloxetine (an antidepressant)
What this could lead to
If this works, it could point toward a way to prevent depression in older adults after a serious injury like a broken leg.
What could go wrong
This is a small pilot study, so results may not apply to everyone. It only tests feasibility, not whether duloxetine truly prevents depression. Side effects of duloxetine are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact