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127005 trials found · Page 4843 of 6351
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New breathing therapy shows promise for Long-COVID breathlessness
Symptom relief CompletedThe aim of the study is to test a treatment known as "Cognitive Muscular Therapy (CMT)" for reducing breathlessness and improving autonomic function in patients with long-COVID.
Sponsor: University of Salford • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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New study tests better ways to clean teeth during root canal retreatment
Symptom relief OngoingIn this superiority randomized clinical trial with a parallel design, 75 asymptomatic maxillary anterior teeth with 2-5 mm periapical lesions and a history of primary root canal treatment (PRCT) at least four years earlier were included. Patients were randomly assigned, using a r…
Sponsor: Ege University • Aim: Symptom relief
Last updated Jun 26, 2026 13:51 UTC
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C-Section shivering showdown: granisetron vs pethidine
Symptom relief CompletedGranisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections
Phase 4 • Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Blood molecules may reveal hidden clues about kidney disease
Knowledge-focused CompletedNon-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored. Anemia resistant to erythropoietin-stimulating agents (ESAs) is a risk factor fo…
Sponsor: Ain Shams University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Spin class showdown: HIIT beats steady cycling for heart health in Couch-Potato men
Knowledge-focused CompletedIn recent years, fitness concepts have continuously evolved, with many seeking to improve and enhance their physical condition through exercise to achieve better athletic performance. Aerobic exercise not only increases lipid utilization but also boosts athletic performance. Cons…
Sponsor: Fooyin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Hand massage before IV insertion eases anxiety for breast cancer patients
Symptom relief CompletedThis is a randomized controlled study to investigate the effect of arm message on the success of peripheral intravenous catheter insertion in breast cancer patients undergoing chemotherapy. There are two groups in our study (control group=30, experimental group=30). The investiga…
Sponsor: University of Yalova • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New pain combo eases liver cancer procedure recovery
Symptom relief CompletedTo evaluate the effectiveness of the combination of hydrochloride hydromorphone and flurbiprofen ester for post-TACE intravenous patient-controlled intravenous analgesia (PCIA).
Phase 4 • Sponsor: First Affiliated Hospital, Sun Yat-Sen University • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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New exercise trick may ease joint pain for hemophilia patients
Symptom relief By invitation onlyIn the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.
Sponsor: University Hospital, Bonn • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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New pain block cocktail could ease surgery recovery
Symptom relief Recruiting nowThis study investigates the effectiveness of adding dexmedetomidine to bupivacaine for postoperative analgesia in patients undergoing abdominal surgeries. The research compares pain relief in two groups: one receiving a combination of bupivacaine and dexmedetomidine via a transve…
Sponsor: Sheikh Zayed Medical College • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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New injection targets stubborn love handles
Symptom relief CompletedFlank region fat is a factor affecting beauty that makes people feel uncomfortable about themselves. In 2015, deoxycholic acid was approved by the American FDA for treatment of flank fat. The purpose of this study is to evaluate the efficacy and safety of deoxycholic acid injecti…
Sponsor: Espad Pharmed • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Ancient shamanic rituals tested for fibromyalgia relief
Symptom relief Recruiting nowThis study aims to determine the feasibility of a shamanism intervention for patients with fibromyalgia, acquire efficacy data to determine if Shamanism reduces clinical pain and other common symptoms associated with fibromyalgia, and determine if the Shamanism intervention chang…
Sponsor: University of California, Irvine • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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AI vs. doctors: who diagnoses better?
Knowledge-focused CompletedA parallel group randomized controlled trial using a superiority framework. Clinical vignettes will be used to assess the impact of a large language model on the clinical reasoning of physicians. Quantitative analyses will be performed on graded vignette responses.
Sponsor: Maastricht University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Music and mindfulness: a new way to ease stress in black communities?
Knowledge-focused Recruiting nowMental health vulnerability due to stress is increased in People of African Descent (PADs) in America due to disproportionate effects of racism, poverty, education, and criminal justice sentencing. Various meditation and mindfulness approaches have provided evidence of measured r…
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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No-Drill cavity treatments for kids put to the test against traditional fillings
Disease control CompletedThe goal of this clinical trial is to compare the 18-month clinical success rates of three caries management approaches in primary molars of 60 healthy children aged 4-8 years attending the Department of Pediatric Dentistry at Erciyes University, using a randomized split-mouth de…
Sponsor: TC Erciyes University • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New dental implant study tests if plastic or metal frameworks better preserve jawbone
Disease control OngoingA fixed all-on-four prosthesis will be constructed for the lower arch for each patient and the marginal bone loss will be evaluated at baseline, 3,6,9 and 12 months.
Sponsor: Cairo University • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Simple vitamin B1 pill may boost brain function in diabetes patients
Symptom relief Recruiting nowThe majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (tak…
Early phase 1 • Sponsor: University of California, Los Angeles • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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New depression pill shows promise in Long-Term safety check
Disease control CompletedThe purpose of this study is to evaluate the long-term safety and tolerability of BHV-7000, in participants with Major Depressive Disorder (MDD).
Phase 2 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Massage may ease pain during pessary checks, new study says
Symptom relief OngoingPessaries are effective non-surgical devices for reduction of prolapse. However, use of pessaries are limited in some women due to patient discomfort. While lidocaine can be used to improve pessary checks, its use may be limited due to supply chain shortages, lack of insurance co…
Sponsor: University of North Carolina, Chapel Hill • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New MRI method shows promise for spotting aggressive bladder cancer
Diagnosis CompletedThis research aimed to determine how accurately multiparametric magnetic resonance imaging (MRI), when interpreted using the VI-RADS scoring system, can distinguish between invasive and non-invasive bladder cancer.
Sponsor: Ain Shams University • Aim: Diagnosis
Last updated Jun 27, 2026 12:32 UTC
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Laser eye surgery showdown: which fix for nearsightedness is better?
Disease control OngoingFemtoLASIK is a type of laser eye surgery used to correct vision problems such as nearsightedness, farsightedness, and astigmatism. It involves two main steps: creating a flap and reshaping the cornea. Refractive lenticule extraction, (KLEx) is another laser eye surgery method to…
Sponsor: Instituto de Oftalmología Fundación Conde de Valenciana • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC