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127005 trials found · Page 4503 of 6351
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Chilled or heated rinses may ease root canal pain, study finds
Symptom relief OngoingThe primary objective of root canal treatment is to clean, disinfect, and hermetically seal the root canal system to prevent bacterial penetration; however, postoperative pain is frequently encountered, particularly in patients with symptomatic irreversible pulpitis. This conditi…
Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Simple NICU routine may boost preemie feeding and language
Knowledge-focused Recruiting nowThis is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings, linguistic feedback, and a language curriculum to improv…
Sponsor: Women and Infants Hospital of Rhode Island • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:42 UTC
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Can a simple touch or cold pack make shots less painful?
Symptom relief CompletedThe ventrogluteal injection is an invasive and often painful procedure commonly performed in healthcare settings. This study aimed to compare the effects of acupressure and cold application on pain, anxiety, comfort, and hemodynamic parameters prior to the ventrogluteal injection…
Sponsor: Mardin Artuklu University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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New toolkit aims to ease pain in nursing homes without drugs
Symptom relief By invitation onlyThe overall aim of this research study is to implement and evaluate the toolkitinto the nursing home by using scientific methods, which is cut down in specific aims. 1. To assess the effectiveness of the toolbox on 1. staff outcomes 2. pain management practice 3. resid…
Sponsor: Medizinische Universität Graz, Institut für Pflegewissenschaft • Aim: Symptom relief
Last updated Jun 26, 2026 13:36 UTC
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Cartoons vs. calming drops: which works better for anxious kids before a procedure?
Symptom relief CompletedThis observational study aims to compare the effects of short video viewing and intranasal dexmedetomidine administration-both of which are part of routine clinical practices in the pediatric endoscopy unit-on preoperative anxiety levels and the need for intravenous sedation. Pat…
Sponsor: Samsun University • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New therapy aims to boost emotional health after kidney transplant
Symptom relief Recruiting nowThe study was designed to evaluate the effects of an emotion-focused intervention based on the Human-to-Human Relationship Model on emotion regulation skills and well-being in individuals who have undergone renal transplantation. This study was designed as a single-blind randomiz…
Sponsor: Akdeniz University • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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New combo extends numbness for leg surgery patients
Symptom relief Recruiting nowSpinal anesthesia is the most widely employed procedure for lower limb orthopedic operations, as it is very cost-effective and simple to apply. These advantages could be restricted because presently existing local anesthetic drugs had relatively short length of action. (1) Spinal…
Phase 4 • Sponsor: Nashwa Ahmed • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Thousands of esophageal cancer patients tracked after surgery
Knowledge-focused CompletedA prospective cohort of patients who received esophagectomy for esophageal cancer in participating centers.
Sponsor: Shanghai Chest Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Can a gel boost gum grafts? new study tests hyaluronic acid for receding gums
Disease control CompletedThis study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be r…
Sponsor: Saglik Bilimleri Universitesi • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Brain and body boost: Dual-Task training shows promise for frail seniors
Symptom relief CompletedThe goal of this clinical trial is to investigate the feasibility and effect of a 10-week dual-task training program on frailty status in community-dwelling older adults with frailty and chronic musculoskeletal pain. Main question: Is a 10-week dual-task training program, that c…
Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New nerve block combo could cut opioid use after thyroid surgery
Symptom relief CompletedEfficacy of Superficial Cervical Plexus Block (SCPB) with Dexmedetomidine Adjuvant Compared to Without Adjuvant in Thyroid Surgery. This is a double-blinded, randomized controlled trial designed to evaluate the effectiveness of adding perineural dexmedetomidine to a Superficial C…
Sponsor: Udayana University • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Battle of the bacteria busters: triple vs quadruple therapy for stomach bug
Disease control By invitation onlyThe Goal of this this clinical trial is to assess and compare the eradication rate of triple and quadruple therapy during treating helicobacter pylori infection among patients presented with dyspepsia. It will also assess the patient reported adverse events among two groups. H p…
Sponsor: Akil Al Islam • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Hearing aids may cut listening fatigue in seniors
Symptom relief CompletedThis randomised controlled trial aims to test the effect of hearing adjustment using hearing aids, on the ease and effectiveness of communication such as listening effort, fatigue, and sentence recognition in noise, in addition to wellbeing and sleep; and to reveal the role of co…
Sponsor: University of Manchester • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Smart fluids during bypass may shield your brain
Symptom relief CompletedPostoperative cognitive dysfunction (POCD) describes a decline in cognitive function as measured by pre- and postoperative neuropsychological testing. It is common after cardiac surgery, affecting 25% to 70% of patients, and is usually associated with pathophysiological mechanism…
Sponsor: TC Erciyes University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Which nerve block cuts opioid use after lung cancer surgery?
Symptom relief Recruiting nowThis randomized trial compares rhomboid intercostal block (RIB) and erector spinae plane block (ESPB) for postoperative pain control in lung cancer patients undergoing thoracotomy. Sixty patients will be assessed for 24-hour morphine consumption, pain scores, hemodynamics, recove…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Sep 03, 2026 00:00 UTC
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Laser boost for gum disease therapy? small study tests new combo
Disease control OngoingThe aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after treatment, among some Yemeni individuals in Sana'a …
Sponsor: University of Science and Technology, Yemen • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Climate-Smart pregnancy: new nursing program boosts preeclampsia awareness
Knowledge-focused CompletedThis randomized controlled trial aims to evaluate the effectiveness of a climate-related nursing intervention in improving pregnancy-specific climate change knowledge, health beliefs, and protective behaviors among pregnant women diagnosed with preeclampsia. Climate change, parti…
Sponsor: Benha University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Botox for bowel leaks? small study tests new hope for kids
Symptom relief Recruiting nowBackground: Fecal Incontinence (FI) is a frustrating and prevalent GI condition with profound social implications and a marked effect on quality of life. Treatment options are limited for children whose FI is not secondary to constipation (overflow incontinence), and they are def…
Early phase 1 • Sponsor: Shaare Zedek Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Which appendix surgery causes fewer blockages? a Head-to-Head comparison
Knowledge-focused CompletedAcute appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention, with appendectomy being the definitive treatment . Traditionally performed through an open approach, appendectomy has evolved significantly with the advent of minimally in…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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Mindful movement may ease work stress and pain — a trial puts it to the test
Knowledge-focused OngoingThis study will examine the effects of a 10-week Basic Body Awareness Therapy (BBAT) program on pain, work-related stress, quality of life, and eating attitudes in healthy adults working at a university. Twenty participants aged 25-55 will be randomly assigned to either an interv…
Sponsor: Hitit University • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC