Xijing Hospital Of Digestive Diseases

This study compares two drugs—upadacitinib (a pill) and infliximab (an infusion)—as second-line treatments for acute severe ulcerative colitis. About 226 adults will be randomly assigned to one of the two drugs for 3 months. The main goal is to see if upadacitinib can reduce symp…

This study is for adults with primary biliary cholangitis (a chronic liver disease) who also have cirrhosis and did not respond well to the usual treatment, ursodeoxycholic acid. Researchers want to see if adding fenofibrate to their treatment can improve liver health by normaliz…

This long-term study is testing whether adding fenofibrate to standard ursodeoxycholic acid is safe for people with primary biliary cholangitis (PBC), a rare liver disease. About 300 adults who have already completed a prior fenofibrate study will take the combination and be moni…

This study tests the long-term safety of combining fenofibrate with standard treatment (ursodeoxycholic acid) in 150 adults with primary biliary cholangitis, a chronic liver disease. Participants previously completed a related study and will take fenofibrate capsules daily. Resea…

This Phase 3 trial tests whether adding fenofibrate to standard ursodeoxycholic acid (UDCA) therapy improves liver health in people with primary biliary cholangitis (PBC) who do not respond well to UDCA alone. About 150 adults will receive either the combination or a placebo plus…

This study tests whether fenofibrate, a drug used for high cholesterol, can improve liver function in adults with primary biliary cholangitis (PBC) who haven't been treated before. About 132 participants will take either fenofibrate or the standard drug UDCA for 12 months. The go…

This trial tests whether a 3D imaging device used during colonoscopy helps doctors find high-risk adenomas—polyps that could turn into cancer—better than the usual 2D view. Adults aged 18-75 scheduled for a diagnostic colonoscopy will be randomly assigned to either a 2D or 3D sco…

This study tests whether using a special imaging technique called Red Dichromatic Imaging (RDI) throughout the entire ESD procedure can reduce serious complications like bleeding and perforation, and shorten surgery time. About 640 adults with early stomach cancer or precancerous…

This trial tests whether a small device that stimulates a nerve in the ear (taVNS) can help people with constipation that hasn't improved with standard treatments. One hundred adults will be randomly assigned to receive either active or sham stimulation twice daily for 20 days. R…

This study tests whether a non-invasive brain stimulation technique called tACS can help people with severe constipation that hasn't improved with standard treatments, especially when they also have stress-related physical symptoms. About 60 adults will receive either real or sha…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This trial tests whether having patients complete a questionnaire about follow-up care, plus receiving feedback, can improve their adherence to scheduled endoscopic surveillance after endoscopic submucosal dissection (ESD) for early gastrointestinal growths. The study will enroll…