University Hospital Tuebingen

This early-stage trial tests a peptide vaccine designed to train the immune system to attack cancer cells that carry a specific genetic change (DNAJB1-PRKACA fusion). It is for people with fibrolamellar liver cancer or other tumors with this same change, who have already achieved…

This study tests a new type of COVID-19 booster vaccine made from a harmless sheep virus. It aims to see if it is safe and boosts immunity in 96 healthy adults aged 18 to 55 who have already been vaccinated or infected. The vaccine is given as a single booster shot, and participa…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. If successful, this approach could help prevent cervical can…

This study tests a drug called tafasitamab in children aged 3 to 17 with a type of leukemia (B-cell ALL) that has come back or not responded to treatment. The goal is to see if the drug is safe and can delay or prevent the cancer from returning after a stem cell transplant. About…

This study tests a continuous intestinal pump (Lecigon) that delivers Parkinson's medication directly to the gut. The goal is to see if this method reduces unwanted mood and behavior problems caused by standard oral drugs. About 150 adults with Parkinson's who qualify for this pu…

This study tests a precise type of radiation, guided by MRI, combined with standard chemotherapy for people with distal rectal cancer. The goal is to destroy the tumor and avoid major surgery to remove the rectum. About 100 participants will receive this treatment to see if it ca…

This study looks at whether intermittent fasting (eating only during certain hours) can improve how much insulin the body makes. Researchers will compare a 4-week fasting plan to a regular diet in 200 adults with prediabetes or early type 2 diabetes. The goal is to see if this ap…

This study tests whether robot-assisted groin lymph node surgery causes fewer serious complications than standard open surgery in 80 men with penile cancer. The goal is to find a safer way to remove lymph nodes while still effectively controlling the disease. Participants will be…

This study tests a mindfulness program called "Healthy under Stress" to see if it can lower stress levels. Researchers will enroll 120 employees, patients, and family members from a hospital. Participants will learn techniques to better cope with stress, and their progress will b…

This study compares brain activity, stress responses, and inflammation in women with major depressive disorder (MDD), premenstrual dysphoric disorder (PMDD), and healthy women. Researchers will use stress tasks, brain imaging, and blood/saliva tests to understand how these condit…

This study is testing whether artificial intelligence (AI) can automatically detect smoke created during laparoscopic surgery. Researchers will collect video footage from 30 women undergoing surgery and use it to train a computer model. The goal is to help surgeons see more clear…

This study follows 300 people with a rare genetic movement disorder called SCA27B, along with some family members and healthy volunteers, for two years. Researchers will track changes in balance, coordination, and other symptoms using exams, digital tools, and lab tests. The goal…

This study is for women with triple-negative breast cancer, either early-stage or advanced, who are receiving immunotherapy. Researchers want to see if changes in a blood marker called CRP can predict how well the cancer responds to treatment. The goal is to find a simple way to …

This study looks at electrical signals from surgical tools to see if each type of surgery has its own unique pattern, like a digital fingerprint. Researchers will collect data from 160 adults having specific gynecologic or breast surgeries. The goal is to use these patterns for t…