University Hospital Tuebingen

This study is testing a personalized peptide vaccine for children and young adults (up to age 30) with metastatic fusion-driven sarcomas (Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma) who have completed standard treatment. The vaccine is custom-made for each patient based on…

This early-stage trial tests a personalized peptide vaccine for people with a rare liver cancer called fibrolamellar hepatocellular carcinoma (FLC) or other tumors that share a specific genetic change (DNAJB1-PRKACA fusion). The vaccine is designed to train the body's immune cell…

This study tests whether a special MRI-guided radiation machine (MR-linac) can deliver high-dose radiation precisely to rectal tumors, allowing patients to avoid surgical removal of the rectum. About 100 people with early-stage rectal cancer will receive this radiation along with…

This study tests a treatment called Lecigon® for people with Parkinson's disease. It is a gel given through a tube into the intestine that delivers a steady dose of medication. The goal is to see if this method reduces certain behavioral and emotional side effects better than sta…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study tests a drug called tafasitamab in children aged 3 to 17 with a type of leukemia (B-cell ALL) that has come back or not responded to treatment. The goal is to see if the drug is safe and can delay or prevent the cancer from returning after a stem cell transplant. About…

This study tests whether robot-assisted groin lymph node removal causes fewer serious side effects than standard open surgery in 80 men with penile cancer. The goal is to reduce wound healing problems and other complications while still effectively controlling the cancer. Partici…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor (glioblastoma) live longer. About 146 adults aged 18 to 70 with a specific type of glioblastoma will receive the treatment. The goal is …

This study is testing an artificial intelligence system that can automatically detect smoke gas produced during laparoscopic surgery. Researchers will collect video data from 30 women undergoing procedures that use high-frequency surgery, which creates smoke. The goal is to train…

This study tests a mindfulness program called 'Healthy Under Stress' to see if it can lower stress levels. The program teaches mindfulness, healthy eating, and exercise. Researchers will measure stress in 120 employees, patients, and family members using a standard questionnaire.…

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This study compares quality of life in adults with Crohn's disease during a flare when treated with either standard care or an adapted diet plus liquid nutrition. About 52 participants will be assigned to one of two groups. The goal is to see if the diet approach leads to better …

This study looks at how the menstrual cycle and preoperative hormone therapy affect a marker called Ki67 in women with early hormone-positive breast cancer. Researchers will also see if adding a genetic test (PAM50) changes treatment recommendations. About 504 women will particip…

This study follows 845 people who previously received a Melody valve implant to see how well the valve works over many years. Researchers will track serious events like death, repeat surgery, or infections. The goal is to understand the long-term safety and performance of this he…

This study watches about 185 people with anorexia or bulimia during a multi-week hospital program to help them regain weight. Researchers track stomach and bowel symptoms weekly and see if these symptoms change differently depending on whether the person follows a flexitarian, ve…

This study creates a registry for people with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. Researchers will collect information on how the disease progresses, what treatments are used, and any side effects. The goal is …

This study looks at electrical signals from surgical tools during different types of surgery. Researchers want to see if each surgery type creates a unique pattern, like a digital fingerprint. About 160 adults having certain gynecologic or breast surgeries will take part. The goa…

This study is collecting blood samples from 13,500 breast cancer patients, both early-stage and advanced, to find biomarkers that could predict how well a treatment works. The goal is to replace invasive tumor biopsies with simple blood tests. No new drugs are being tested; inste…

This study tests an app designed to help families of premature babies track their mental and physical health after leaving the hospital. The goal is to identify problems early and offer personalized support. About 120 families with babies born between 28 and 34 weeks will partici…

This study follows 300 people with a rare genetic movement disorder called SCA27B, along with some family members and healthy volunteers, for up to 2 years. Researchers will use exams, digital devices, and blood tests to measure how the disease changes over time. The goal is to f…

This study looks at how stress and inflammation affect the brains of women with major depressive disorder (MDD) or premenstrual dysphoric disorder (PMDD). Researchers will compare brain scans, stress responses, and immune markers in 75 naturally cycling women. The goal is to bett…

This study looks back at genetic test results from about 12,000 people with rare diseases or family cancer syndromes. Researchers want to see how often newer DNA sequencing methods find a diagnosis compared to older tests. No new treatments are given; the goal is to learn which t…

This study looks at why some patients experience heart injury after non-cardiac surgery. Researchers will track 3000 adults aged 40-80 with heart risks to see how anesthesia and surgery factors contribute. The goal is to find ways to better monitor and protect high-risk patients …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study is for women with triple-negative breast cancer, either early-stage or advanced, who are receiving immunotherapy. Researchers want to see if changes in a simple blood marker called CRP can predict how well the treatment works. The goal is to find a way to personalize t…