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Brain scans and stress tests aim to unravel PMDD vs depression

NCT ID NCT06130371

Knowledge-focused Sponsor: University Hospital Tuebingen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal is to better understand PMDD and distinguish it from MDD.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could improve understanding of PMDD and its differences from MDD, potentially guiding better diagnosis or future treatments.
What could go wrong
This is an observational study with only 75 participants, so results may not apply to everyone. It aims to gather knowledge, not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited by newspaper/social media advertisements, e-mails ("Rundmail") and posting notices ("Aushänge") at different places at the University Hospital Tübingen as well as the University of Tübingen and in social networks.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women, * age between 18 and 40 years (no menopausal women), * regular menstrual cycles (25-31 days), * normal body mass index (18-35 kg/m2), * German language fluency Exclusion Criteria: * any neurological or mental disease (only for healthy participants) * hormonal, metabolic or chronical diseases * pregnancy * women who gave birth or were breastfeeding within the last year * women with any kind of steroid hormonal treatment * oral contraceptive treatment in the last three months * psychotropic treatment, only if regular * engagement in competitive sports * shift work

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Conditions

The condition(s) this trial relates to.

endogenous depression Inflammation major depressive disorder premenstrual dysphoric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MDD PMDD

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital Tübingen, Klinik für Psychiatrie und Psychotherapie

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

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