University Hospital, Tours

This study tested whether adding methotrexate to adalimumab treatment helps prevent the body from developing antibodies against adalimumab in people with ankylosing spondylitis. Researchers enrolled 110 adults with active ankylosing spondylitis who hadn't responded well to standa…

This study tested whether applying a sirolimus solution directly to the tongue could help control lymphatic malformations—rare clusters of fluid-filled cysts that cause bleeding, pain, and difficulty speaking or eating. Researchers compared the topical treatment against no treatm…

This study tested whether adding rituximab to standard mycophenolate treatment helps patients with progressive lung scarring who didn't improve on their first treatment. 122 adults received either the drug combination or mycophenolate alone for 6 months. Researchers measured whet…

This study tested whether the drug sirolimus could shrink painful, complicated vascular malformations (abnormal tangles of blood or lymph vessels) in children. 63 participants aged 6-18 were followed for a year, first without treatment and then while taking sirolimus, to compare …

This study compared two types of stents used in a liver shunt procedure for people with advanced cirrhosis. Researchers wanted to see if more expensive coated stents, which rarely get blocked, are actually more cost-effective than cheaper uncoated stents that often need follow-up…

This large study tested whether adding a low-dose steroid (hydrocortisone) to standard antibiotic and breathing support treatment could help more critically ill patients survive severe pneumonia. It involved 952 adults in intensive care with life-threatening pneumonia. The goal w…

This small study tested whether getting a flu shot directly reduces harmful inflammation in people with stable coronary artery disease. Researchers gave 47 participants the vaccine either right away or after a one-month delay, then measured inflammation markers in their blood. Th…

This study tested whether adding the drug rituximab to standard treatment could better control a serious type of kidney transplant rejection caused by the patient's antibodies. It involved 40 adults whose transplanted kidneys were showing signs of this antibody attack within a ye…

This study tested if a continuous glucose monitor worn on the skin could better manage low blood sugar in very small premature babies. 48 babies were randomly assigned to either the new continuous monitor or the standard method of periodic finger-prick tests. The goal was to see …

This study tested whether levetiracetam, an anti-seizure medication, is safe and effective as the first treatment for seizures in newborn babies who experienced oxygen deprivation around birth. Researchers gave the drug to 18 full-term newborns within their first 3 days of life t…

This study tested whether a phone-based therapy program could help people with severe obesity and food addiction. 154 participants were assigned to receive either 12 weeks of phone therapy sessions or their usual medical care. Researchers wanted to see if the therapy could reduce…

This study tested whether a simple phone call could help people with chronic heart or mental health conditions during the COVID-19 lockdown in France. Medical students called over 22,000 patients to check on their health and see if they needed their doctor. The goal was to see if…

This study compared two methods to help start labor in pregnancies that have gone past 41 weeks. Researchers wanted to see if using a mechanical balloon device was gentler and led to fewer C-sections for suspected fetal distress than using a hormonal pessary. Over 1,200 pregnant …

This study tested if patients with a serious staph infection of the heart valve could safely switch from intravenous (IV) antibiotics in the hospital to oral antibiotic pills taken at home. It involved 162 adults who were stable after at least 10 days of IV treatment. The goal wa…

This study aimed to find out if a shorter, 6-week course of antibiotics works as well as the standard 12-week course for treating infections in hip or knee replacements. It involved 410 adults in France who had surgery for their infection. The main goal was to see if the shorter …

This study tested a topical cream containing 0.1% sirolimus to see if it could improve a rare skin condition called cutaneous microcystic lymphatic malformation (CMLM). In 55 children and adults, researchers compared the cream to an inactive version (a placebo) by applying each t…

This study tested whether a mild, non-invasive brain stimulation technique called tDCS could improve the results of standard trauma-focused talk therapy for people with chronic Post-Traumatic Stress Disorder (PTSD). It involved 63 adults who had PTSD for 3 months to 10 years. Res…

This study tested whether HIV patients with well-controlled virus could safely switch from three-drug to two-drug therapy. Researchers wanted to see if this simpler treatment could maintain viral suppression while reducing medication side effects and costs. The trial involved 224…

This study tested whether patients with a serious heart valve infection could safely switch from intravenous (IV) antibiotics in the hospital to oral antibiotics at home. It involved 324 adults who had already received at least 10 days of IV treatment and were stable. The goal wa…

This large study aimed to see if a less invasive approach to monitoring blood pressure is as safe as the standard method for patients in shock. It compared waiting to insert an artery tube only if truly needed versus inserting one right away. The main goal was to see if the less …

This study tested whether a new method for measuring kidney function is practical to use in intensive care unit (ICU) patients. It involved 100 adults recently admitted to the ICU with unstable blood pressure. Researchers gave participants a single injection of a safe contrast dy…

This study tested whether adding a contrast agent to ultrasound scans helps doctors better identify liver abnormalities. Researchers compared this enhanced ultrasound method against standard scans in 878 people with liver lesions. The goal was to see if this approach could provid…

This study tested whether a chest ultrasound, which is simple and radiation-free, can detect early signs of lung scarring in people with scleroderma. Researchers enrolled 30 scleroderma patients who did not yet show lung disease on standard CT scans. The goal was to see if ultras…

This study tested a special type of ultrasound scan that uses a safe contrast dye to see if it could better detect a serious condition called placenta accreta. Placenta accreta can cause life-threatening bleeding after childbirth. The researchers enrolled 80 pregnant women at hig…

This study tested a new medical device called an elastograph to see if it can measure skin stiffness in people with chronic limb swelling from lymphedema or poor vein function. Researchers compared skin measurements from 88 patients with these conditions to 48 healthy volunteers.…

This large study tested whether inhaling an antibiotic (amikacin) for three days could prevent pneumonia in patients on breathing machines. It involved 850 adults in intensive care who had been on ventilators for more than three days. Patients were randomly assigned to receive ei…

This study tested whether taking a daily low-dose aspirin pill early in pregnancy could prevent two serious complications: pre-eclampsia (dangerous high blood pressure) and having a baby that is too small. It focused on first-time mothers who were identified as high-risk by a spe…

This study tested if giving a written advice sheet to melanoma patients, to pass to their close family members, would encourage more family members to get a skin check from a doctor. Family members of melanoma patients have a higher risk of getting it themselves, so early detecti…

This study tested two ways to get more women to screen for cervical cancer. It compared mailing a simple, at-home vaginal swab kit directly to women versus sending them a letter inviting them to get a kit from their doctor. The goal was to see which method worked better to reach …

This study tested a two-vaccine strategy to prevent serious pneumococcal infections, like pneumonia, in adults with a type of blood cancer (DLBCL) who were receiving chemotherapy. Researchers wanted to see if giving two different vaccines in a specific order, and testing differen…

This study tested a new weekly antibiotic schedule to prevent painful urinary tract infections (UTIs) in adults with neurogenic bladder, a condition often caused by spinal cord injury or neurological disease. Participants took one antibiotic one week and a different one the next,…

This study compared two different surgical methods for fixing broken hips in people over 65. Researchers wanted to see if a newer, less invasive technique caused less bleeding during and after surgery than the standard method. They measured blood loss, hospital stay length, and r…

This study tested whether having conscious COVID-19 patients with severe breathing difficulties lie on their stomachs (prone position) while receiving high-flow oxygen through the nose could improve their outcomes. The goal was to see if this simple, non-invasive technique could …

This study investigated whether daily smell training could improve mood and emotional perception in people with depressive symptoms. Researchers enrolled 150 participants, including both healthy individuals and those diagnosed with depression, to test if practicing with different…

This study tested if delivering a common breathing medicine (salbutamol) through a new high-flow nasal system was as effective as the standard mask method for people with COPD. It involved 25 adults with COPD to see if both methods improved their ability to breathe out air. The g…

This study tested whether a one-hour treatment with nitrous oxide (laughing gas) could provide rapid relief from depression symptoms in older adults who haven't responded to standard antidepressants. Researchers compared nitrous oxide to regular medical air in 60 participants age…

This study investigated whether the color of the artificial lens implanted during cataract surgery affects a patient's sleep. Researchers compared yellow-tinted lenses, which filter more blue light, to standard white lenses in 400 patients aged 60-90. They measured changes in sle…

This study tested if adding a common inhaled medicine (salbutamol) helps adults having a severe flare-up of COPD while they are using a breathing machine. 43 participants were randomly given either the real medicine or a placebo (dummy treatment) to compare the effects. The main …

This study collected blood and bone marrow samples from 102 healthy volunteers to understand how age affects the body's natural antioxidant systems. Researchers compared three age groups (18-39, 40-59, and 60-85 years) to measure antioxidant gene expression and reactive oxygen le…

This study tested whether analyzing the fluid from kidney transplant machines could help predict how well the transplant will work. Researchers studied 40 kidney transplants to see if chemical patterns in the machine fluid could indicate transplant quality. The goal was to find b…

This study aimed to better understand how a laser treatment for an enlarged prostate works. Researchers used MRI and ultrasound scans to measure the area of tissue affected by the laser in 12 men over a year. The goal was to see how this treated area changes and if it relates to …

This study investigated whether mindfulness meditation training changes brain chemistry and improves memory in students. Researchers compared 30 female students who received either mindfulness training or muscle relaxation training over 6 weeks. They used brain scans and memory t…

This study aimed to find biological markers that could predict which patients might develop dry eye or other surface problems after cataract surgery. Researchers collected tiny samples of fluid and cells from the eye's surface before and during surgery from 100 participants. By a…

This study aimed to find new ways to diagnose and track Amyotrophic Lateral Sclerosis (ALS) by analyzing chemicals in tears and cells from the eye's surface. Researchers compared 55 people with ALS to people without the disease to see if the chemical makeup of tears could serve a…

This study aimed to understand how weight loss affects muscle energy production in women with ovarian or endometrial cancer. Researchers compared 70 women with cancer-related weight loss to women having surgery for non-cancerous conditions. They analyzed muscle and tissue samples…

This study aimed to find biological markers in the blood, urine, and other samples that could help explain why up to 40% of people with depression do not respond to standard antidepressant medications. Researchers enrolled 50 adults with major depression who were not taking medic…

This study used special brain scans (PET imaging) to look at a brain chemical called glutamate in adults with autism and Fragile-X Syndrome, comparing them to healthy volunteers. The goal was to better understand the biology of these conditions, not to test a treatment. It involv…

This study tested whether new MRI and ultrasound techniques could better measure muscle changes in people with rotator cuff tears. Researchers worked with 3 participants who had shoulder tears on one side but a healthy shoulder on the other. The goal was to see if these imaging m…

This study aimed to find biological markers (biomarkers) in muscle and blood to help diagnose ALS faster and understand the disease better. Researchers analyzed samples from 37 people, comparing those with ALS to healthy volunteers. The goal was to identify unique chemical patter…

This small study tested whether a vibrating breathing device could help inhaled medicine reach the scarred parts of the lungs in people with idiopathic pulmonary fibrosis (IPF). Nine patients inhaled a safe, traceable mist with and without the device to see where it landed. The m…

This study tested a new ultrasound method to measure natural brain pulsations. Researchers enrolled 53 healthy adults to see how these pulsations change as people get older. The goal was to understand normal brain aging, not to treat a disease.

This study aimed to check how accurate a special type of brain scan is at mapping the brain's internal wiring. Researchers compared scan images from living volunteers with detailed examinations of donated brain tissue after death. The goal was to make this scanning technique more…

This study aimed to understand why cancer patients with weight loss experience muscle weakness and fatigue. Researchers examined muscle tissue from 51 patients with gastrointestinal cancer, comparing those with significant weight loss to those without. The goal was to learn how c…

This study aimed to understand the metabolic changes in Amyotrophic Lateral Sclerosis (ALS) by comparing skin cells from patients and healthy volunteers. Researchers took small skin samples from 9 participants to grow cells and analyze their chemical makeup. The goal was to find …

This study aimed to understand if adults with phenylketonuria (PKU) have hidden, low-level inflammation in their bodies. Researchers compared 40 participants—half with PKU and half healthy volunteers—by measuring inflammation markers in their blood. The goal was to gather basic k…

This study aimed to learn more about port wine stains, which are red birthmarks, when they appear on a child's leg. Researchers followed 150 children in France for five years to see how the birthmarks changed as the child grew and to check for any related health problems. The goa…

This study aimed to find out if a person's genes can predict how well they will respond to a common antidepressant. Researchers looked at a specific gene in 188 adults with major depression who were taking the medication escitalopram. They compared the genes of people who got bet…

This study aimed to find biological markers that could predict whether a patient's advanced prostate cancer would respond to specific treatments. Researchers analyzed tiny molecules called microRNAs in blood and tissue samples from 33 patients. The goal was to help doctors choose…

This study aimed to understand how depression affects the body's physical responses and brain activity during emotional experiences. Researchers compared 76 women—some currently depressed, some recovered from depression, and some healthy—measuring heart rate, breathing, skin resp…

This study aimed to find out if measuring the amount of adalimumab (Humira) in a patient's blood can predict how well the drug will control their rheumatoid arthritis. Researchers followed 69 patients for 6 months, checking drug levels and disease activity markers. The goal was t…

This study looked at whether ultrasound scans of the cervix could help doctors better predict how long it would take for labor to start after induction. It involved 342 pregnant women whose cervixes were not yet ready for birth. The goal was to see if ultrasound data could improv…

This study aimed to understand how nitrous oxide (laughing gas) might help people with depression that hasn't responded to other treatments. Researchers used ultrasound and MRI brain scans on 30 women (20 with depression and 10 healthy volunteers) before, during, and after a one-…

This study investigated whether performing a routine urine culture test before removing a urinary stent (called a double J catheter) actually helps prevent infections afterward. Researchers followed 2,200 adult patients who had their stents removed to see if those who got the sta…

This study aimed to better understand complex post-traumatic stress disorder (PTSD) by identifying how its symptoms differ from standard PTSD. Researchers enrolled 300 adults, including both patients and volunteers, to complete detailed questionnaires about their trauma, emotions…