University College, London

This study is testing whether a surgically implanted brain stimulation device can reduce seizure frequency in children with Lennox-Gastaut syndrome, a severe form of epilepsy. Children aged 5-14 who haven't responded to medications will have the device implanted and be randomly a…

This trial is testing if a 12-week course of stronger antibiotics combined with a urinary antiseptic is more effective at reducing infection and symptoms than the standard low-dose treatments for chronic UTI. It will involve 192 women in the UK who experience daily UTI symptoms. …

This trial aims to find the best way to treat people who have early signs of tuberculosis (TB) on a chest X-ray but whose sputum tests come back negative. It will test whether shorter courses of TB drugs (from 8 to 24 weeks) work as well as the standard 6-month treatment, or if c…

This trial is testing a new radioactive drug called Actinium rhPSMA-10.1 for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The drug is designed to find and destroy prostate cancer cells throughout the body using targeted …

This study is testing a new questionnaire designed to help dentists and doctors identify a severe facial pain condition called trigeminal neuralgia. The goal is to see if the questionnaire can accurately spot patients who might have this condition, which is often mistaken for a t…

This study is testing whether an intensive, 4-week speech and language therapy program can meaningfully improve communication, mood, and quality of life for people with aphasia after a stroke. It will compare the program, which provides about 100 hours of therapy, to the standard…

This study tests whether connecting lonely students with community activities through school support workers is better than simple signposting at reducing loneliness. Researchers will enroll 215 students across 30 English schools who report feeling lonely. Students will either re…

This study is testing whether adding 'social prescribing' to therapy helps teens with anxiety or depression. Social prescribing connects young people to community activities like sports, arts, or volunteering. The study will enroll 120 teens aged 11-18 who are already in therapy …

This study is testing whether a headband device that delivers gentle electrical stimulation to the brain is a practical and acceptable home treatment for chronic migraine. Twenty participants will use the device daily for three months to see if they can stick with the routine and…

This study aims to understand why some people develop problematic scarring (called PVR) after surgery to repair a detached retina. Researchers will analyze fluid from the eye and use special imaging and AI to look for signs that predict who is at high risk. The goal is to gather …