University College, London

This trial is testing whether giving the immunotherapy drug pembrolizumab before surgery can improve outcomes for people with high-risk stage 2 or stage 3 colorectal cancer that has a specific genetic feature called mismatch repair deficiency. About 88 participants will receive p…

This early-phase trial is testing a type of immunotherapy called CD19CAR T-cells in people aged 16 and older with relapsed or refractory primary CNS lymphoma, a rare cancer of the brain or spinal cord. The treatment involves collecting a patient's own immune cells, engineering th…

This phase 2 trial is testing a combination of two drugs, acalabrutinib and rituximab, in elderly or frail patients who have not yet been treated for mantle cell lymphoma. The goal is to see how well the drugs shrink or control the cancer. The study involves 48 participants aged …

This study looks at whether low-risk thyroid cancer patients need radioactive iodine treatment after having their thyroid removed. About 504 participants are randomly assigned to receive either a standard dose of radio-iodine or no radio-iodine at all. The goal is to see if skipp…

This phase II trial tests whether adding stereotactic ablative radiotherapy (SABR) to standard anti-cancer therapy improves survival for people with non-small cell lung cancer that has spread to only a few spots (oligometastatic). About 140 participants are randomly assigned to r…

This early-stage trial tests a new treatment called GD2 CAR T cells in 12 children and teens (ages 1-16) with neuroblastoma that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, modifying them to better recognize and …

This study looks at whether giving children with acute lymphoblastic leukemia a daily antibiotic called ciprofloxacin can reduce bacterial infections during the first month of chemotherapy. About 313 children in the UK are taking part. The goal is to see if this approach works be…

This early-stage trial tests a personalized therapy where a patient's own immune cells are genetically modified to recognize and attack cancer cells that carry a protein called CD19. It includes adults with certain types of leukemia, lymphoma, or chronic lymphocytic leukemia that…

This study explores whether a low-cost, portable MRI machine enhanced with artificial intelligence can detect brain abnormalities in people with epilepsy as accurately as standard high-field MRI. About 30 adults with epilepsy who have already had a high-field MRI will also receiv…

This study tests whether new types of MRI scans can tell the difference between aggressive and harmless kidney tumors before surgery. Currently, standard scans can find tumors but can't tell if they are dangerous. 30 adults with small kidney tumors will get an extra MRI before th…

Researchers are testing whether Azerbaijani national dance sessions can improve cardiorespiratory fitness and quality of life in older adults with chronic heart failure. The trial enrolls 120 people aged 65 to 85 whose heart failure is confirmed by an ejection fraction between 40…

This study tests whether a school-based program called social prescribing can help young people who feel lonely. Instead of medicine, a link worker helps them find activities and support in their community. About 215 students in England will either get this program or just a list…

This trial tests a new surgical method called NeuroSAFE, which uses real-time tissue analysis during robotic prostate removal to help surgeons avoid damaging nerves that control erections and bladder function. About 407 men with prostate cancer will be randomly assigned to receiv…

This trial tests whether an artificial intelligence program can automate two key steps in radiotherapy planning: outlining areas at risk of tumor spread or radiation damage, and designing the radiation beams. The AI tool is compared against the standard manual process done by onc…

This study investigates whether advanced eye imaging and artificial intelligence can predict proliferative vitreoretinopathy (PVR), a condition that can cause retinal detachment surgery to fail. Researchers will analyze scans from 100 patients with retinal detachment, some with P…

This study tests whether Electrical Impedance Tomography (EIT) can produce accurate images of brain activity in people with epilepsy. EIT uses harmless electrical signals through electrodes on the scalp or brain to create images, and is compared to standard methods like MRI and E…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study, called PARADIGM, is not testing a new drug. Instead, it looks at whether analyzing DNA from a blood sample can tell doctors which standard treatment—like hormone therapy or chemotherapy—will work best for a patient with metastatic prostate cancer. Researchers will tak…

This study looks at the genetic makeup of lung cancers found through low-dose CT screening. Researchers want to understand why some cancers grow quickly and others grow slowly. About 526 people who had surgery for screen-detected lung cancer will provide tissue samples for DNA an…

This study follows 814 people with early-stage non-small cell lung cancer to understand how the cancer evolves and spreads. Researchers collect tumor samples and medical data to see how genetic changes relate to treatment outcomes. The goal is to find ways to reduce the chance of…

This study looks at how stressed surgeons get during hip and knee replacement surgeries, comparing traditional methods with robot-assisted ones. Six experienced orthopedic surgeons will wear a brain-monitoring headband and heart rate monitors while they operate. The goal is to un…