Unity Health Toronto

This study looks at two ways to treat a broken thigh bone near a knee replacement in people 65 and older. One method uses plates and screws to fix the bone, while the other replaces the knee joint with an artificial one. The goal is to see which surgery leads to less pain and bet…

This study tests whether giving vouchers for healthy foods can help people with type 2 diabetes or prediabetes who have low incomes lower their blood sugar levels. About 390 participants will receive vouchers or standard care. The main goal is to see if blood sugar (measured by A…

This study tests whether setting a breathing machine based on each patient's lung mechanics can lower the chance of death by day 60 in people with acute respiratory distress syndrome (ARDS). About 740 adults with moderate to severe ARDS, including those with COVID-19, will take p…

This study tests a virtual program for adults with type 1 diabetes that includes short video visits with educators and online classes. The goal is to help people manage their blood sugar better without needing as many in-person clinic visits. About 580 participants will be enroll…

This study compares two surgeries for a broken thigh bone just above the knee in people aged 65 and older. One option uses plates and screws to hold the bone together while it heals, but often requires weeks of limited movement. The other replaces the damaged knee joint with an a…

This study looks at whether giving trauma patients whole blood instead of separate blood parts (red cells, plasma) before they reach the hospital is practical and improves outcomes. About 60 adults with major traumatic bleeding will be randomly assigned to receive either two unit…

This study looks at whether giving a lower total amount of epinephrine during resuscitation from cardiac arrest helps more people survive to leave the hospital. About 3,790 adults whose heart stops due to a shockable rhythm will be randomly assigned to receive either a low or sta…

This study is checking if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results with standard lab tests. The goal is to make testing more accessible, especially for people experiencing…

This study tests whether a single intensive therapy session called Brief Skills for Safer Living can reduce suicidal thoughts in adults. 150 participants across Canada will be randomly assigned to receive the therapy right away or after a 3-month wait. The goal is to see if this …

This study tests a 12-week therapy called Integrated Suicide and Trauma Therapy (ISTT) for adults who had childhood trauma and are currently thinking about suicide. The therapy combines coping skills training with trauma-focused care to reduce suicidal thoughts. The study involve…

This study tests whether giving a steroid injection in the non-surgical knee before a total knee replacement can reduce pain and improve function. About 60 adults with knee osteoarthritis who need a single knee replacement will participate. The injection is given in the opposite …

This study tests whether Lemborexant, a sleep medication, can help adults with treated depression who still struggle with insomnia. About 30 participants will take either the drug or a placebo daily for 6 weeks, tracking sleep and symptoms. The goal is to see if the drug is pract…

This study tests a non-invasive light therapy device (Neuro RX Gamma) for people with mild cognitive impairment (MCI) due to Alzheimer's disease. It aims to see if the treatment is safe, feasible, and can improve memory and thinking. About 60 adults aged 50 and older with MCI wil…

This small pilot study is testing whether a single dose of MDMA (ecstasy), combined with talk therapy, can safely reduce severe chronic nerve pain. Forty adults with long-lasting nerve pain will receive either MDMA or a placebo during a therapy session, followed by more therapy s…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study tests a digital platform called the Genetics Navigator, designed to help patients and parents of children who are offered genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults will participate, …

This study looks at two common surgeries for broken hips in people aged 60 and older: one uses plates and screws to fix the bone, and the other replaces the hip joint entirely. Researchers want to see which approach leads to better pain relief and daily function. About 104 partic…

This study tests a program that provides job placement, housing help, food support, coaching, and community connections to young people aged 18-24 who are moving out of homelessness. The goal is to see if the program is practical and helpful. Researchers will track how many youth…

This study aims to understand why some people with depression do not get better with standard medications. Researchers will use brain scans to compare dopamine receptors in three groups: people with treatment-resistant depression, those whose depression responds to treatment, and…

This study looks at how a device called AbClo, which gently holds the belly together after surgery, affects breathing in patients whose abdomen is left open. Researchers will measure lung pressure and volume before and after adjusting the device, and again after the abdomen is cl…