Unity Health Toronto
Clinical trials sponsored by Unity Health Toronto, explained in plain language.
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Laughing gas lifts depression: brain scans reveal how
Symptom relief CompletedThis small pilot study tested whether laughing gas (nitrous oxide) can improve mood in people with major depression. Eleven participants received either laughing gas or a sedative (midazolam), and researchers used MRI brain scans to look for changes in brain activity. The goal wa…
Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 22, 2026 14:04 UTC
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Heart surgery patients may need fewer opioids with new pain block
Symptom relief CompletedThis study tested a pain-relief method for adults having open-heart surgery. Half received a numbing medicine (ropivacaine) through small tubes placed near the breastbone, while the other half got a saltwater placebo. The goal was to see if the nerve block could lower the amount …
Phase: NA • Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 22, 2026 13:50 UTC
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Can talk therapy boost Ketamine's pain relief? small study hints at yes
Symptom relief CompletedThis pilot study tested whether combining ketamine with psychotherapy (cognitive behavioral therapy) helps people with chronic nerve pain more than either treatment alone. 30 adults with moderate-to-severe neuropathic pain were randomly assigned to receive ketamine, psychotherapy…
Phase: PHASE4 • Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated May 19, 2026 11:48 UTC
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Can a rent check and a coach help homeless youth build a new life?
Knowledge-focused CompletedThis pilot study tested whether giving young people (ages 16-24) who recently left homelessness a rent subsidy plus a special coaching program helps them stay stable and build better lives. All 40 participants got rent help; half also got a coach and a guide to build confidence a…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 26, 2026 08:57 UTC
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Personal navigators boost staff wellness in nursing homes
Knowledge-focused CompletedThis study tested whether giving long-term care and retirement home staff a personal 'resource navigator' could improve their wellness and reduce burnout. 123 workers in Ontario were split into two groups: one got one-on-one support to find health and wellness resources, the othe…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 26, 2026 08:55 UTC
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New approach aims to capture social needs of overlooked patients
Knowledge-focused CompletedThis study tested whether a community health surveyor can help collect social and demographic information from adult primary care patients who are often hard to reach, such as those with low income or housing issues. Researchers compared usual questionnaire methods to an enhanced…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 26, 2026 08:54 UTC
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New program helps homeless youth build confidence and purpose
Knowledge-focused CompletedThis study tested a 4-week in-person leadership program for young people aged 16-24 who recently left homelessness. 25 participants in Toronto and St. Catharines attended sessions to build confidence and life skills. The goal was to see if the program was helpful and if it improv…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 26, 2026 08:53 UTC
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Navigator program aims to keep homeless patients out of the hospital
Knowledge-focused CompletedThis study tested a program where navigators helped homeless adults after they left the hospital. The goal was to see if this support would help them see a primary care doctor and reduce the need for future hospital visits. Over 650 homeless adults took part, and the program focu…
Phase: NA • Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 26, 2026 08:19 UTC
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Brain scan hunt for suicide clues
Knowledge-focused CompletedThis study looked for biological signs (biomarkers) that could help predict suicide risk in people with major depression. Researchers used brain scans to measure how the brain processes pain, reward, and attention. 97 adults with depression took part, but no treatment was given. …
Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 20, 2026 11:57 UTC
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Large study sheds light on brain bleed risks in rare blood vessel disorder
Knowledge-focused CompletedThis study aimed to find out what makes some people with hereditary hemorrhagic telangiectasia (HHT) more likely to have bleeding in the brain. Researchers collected health information and blood samples from over 2,200 participants across North America. The goal was to better und…
Sponsor: Unity Health Toronto • Aim: Knowledge-focused
Last updated May 19, 2026 11:48 UTC