Unity Health Toronto

This trial tests whether apixaban, a blood thinner, can reduce the risk of stroke or blood clots in adults on dialysis who also have atrial fibrillation (an irregular heartbeat). Participants are randomly assigned to receive either apixaban or no oral anticoagulant, while continu…

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This early study tests a new robotic surgical system (Revolve) in 3 adults with simple appendicitis who are already scheduled for appendix removal. The robot helps the surgeon work more precisely during minimally invasive surgery. The main goal is to see if the device can safely …

This trial is testing whether the GeneXpert system, a portable device that can run multiple tests, can accurately detect HIV, chlamydia, gonorrhea, hepatitis C, and HPV in community health centers and clinics. Researchers will compare its results to standard lab tests and track w…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

This study tests whether Functional Electrical Stimulation (FES) of facial muscles is a safe and effective way to reduce depression symptoms in people with major depressive disorder (MDD). About 60 adults with MDD who have not responded to up to two treatments will receive FES or…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This study tests new breathing devices for people with breathing failure and high carbon dioxide levels. Standard masks can be uncomfortable, causing patients to stop treatment. The study compares a new nasal cannula and a redesigned mask to standard masks, measuring breathing ef…

Researchers are testing a digital platform called The Genetics Update to help patients receive updated genomic results more quickly and with less distress. The study compares this platform to standard genetic counseling and letters in 170 adults who had genome sequencing in earli…

This trial tests whether a digital-supported consent process — including a procedure-specific educational video and an offline AI question-answering tool — helps patients better understand the risks, benefits, and alternatives of advanced therapeutic endoscopy. Adult patients sch…

This pilot study will test a simple idea: giving vulnerable people who don't have a family doctor the name of a specific doctor who is taking new patients. Researchers will compare this to just giving them general information on how to find a doctor. The goal is to see which meth…