New breathing masks aim to make Life-Saving treatment more comfortable
NCT ID NCT07157098
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests new breathing devices for people with breathing failure and high carbon dioxide levels. Standard masks can be uncomfortable, causing patients to stop treatment. The study compares a new nasal cannula and a redesigned mask to standard masks, measuring breathing effort, CO2 removal, and comfort. It involves 24 adults in the intensive care unit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- asymmetrical high-flow nasal cannula and new mask designs
- What this could lead to
- If successful, this could point toward more comfortable and effective breathing support for people with breathing failure, reducing discomfort and treatment interruptions.
- What could go wrong
- This is a very early, small study with only 24 participants. The new devices may not work better than standard masks, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Aug 2025
An estimate. Start dates often move.
- Expected to finish
-
Jul 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed with acute hypercapnic respiratory failure * Admitted to the intensive care unit * Being treated with either high-flow oxygen treatment or non-invasive ventilation Exclusion Criteria: * Clinical instability - defined as the presence of one of the followings: respiratory rate \> 40 breaths/minute, SpO2 \< 80%, active broncho-pleural fistula, Glasgow Coma Scale \< 8, mean arterial pressure below 60 mmHg despite usage of vasopressors * Requiring immediate need of endotracheal intubation, according to the judgement of the attending physician * Contraindications of monitoring with electrical impedance tomography (e.g. pacemaker, chest wall burns wounds limiting electrode placement).
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Acute hypercapnic respiratory failure are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
St. Michael's Hospital
Toronto, Ontario, M5B1W8, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.