Breathing vest tested for hospital patients – but study stopped early
NCT ID NCT06108284
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a negative pressure vest (Biphasic Cuirass Ventilation) to see if it works as well as standard breathing masks for patients hospitalized with acute hypercapnic respiratory failure (high carbon dioxide levels). The trial planned to enroll 50 adults, but it was terminated early. Because of this, we cannot draw firm conclusions about the device's effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Biphasic cuirass ventilation (a negative pressure vest)
- What this could lead to
- If it worked, this device could offer an alternative to standard breathing masks for patients with acute breathing failure.
- What could go wrong
- The trial was terminated early with only 50 participants, so we don't have enough data to know if it works. The device also has specific risks for people with chest injuries or prior surgery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Apr 2024
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * admission diagnosis of hypercapnic respiratory failure * pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample. Exclusion Criteria: * age \<21 * Pregnant * Inmate/Prisoner * Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery) * Chest wall defect, neuromuscular disease or diaphragmatic paralysis. * BMI \>50
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Missouri Hospitals
Columbia, Missouri, 65212, United States
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