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Study aims to improve ventilator weaning by measuring diaphragm strength

NCT ID NCT07206459

Knowledge-focused Sponsor: Unity Health Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study looks at how the amount of air left in the lungs after breathing out affects measurements of diaphragm strength. Researchers will test 30 healthy volunteers and then compare results with ventilated ICU patients. The goal is to develop a way to correct diaphragm strength readings based on lung volume, which could help doctors make better decisions about removing patients from ventilators.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a method to correct diaphragm strength measurements in ventilated patients, potentially improving decisions about weaning them off ventilators.
What could go wrong
This is a small, early-stage observational study in healthy volunteers and a limited number of patients. The findings may not apply to all ICU patients or lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

15 healthy adults and 15 critically ill adult patients admitted to St. Michael's Hospital ICU, Unity Health Toronto, Ontario, Canada. Healthy participants will be recruited by work of mouth from the Grand Toronto Area.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inclusion criteria for the healthy participants will be age ≥18 years, no acute or chronic condition impacting respiratory, musculoskeletal or neurological system or that would interfere with the performance of the tests; body mass index \<35 kg/m2 and sufficient English fluency to provide informed consent and to follow the study protocols. * Inclusion criteria for patients will be intubation for more than 6 hours, triggering or not the ventilator (any mode of ventilation). Exclusion Criteria: * Exclusion criteria for the healthy participants will be contraindication for PNS (e.g., cardiac pacemaker or implanted defibrillator, cervical implants), contraindication for a nasogastric tube (e.g., esophageal varices, recent nasal bleeding)and pregnancy. * Exclusion criteria for patients will be primary contraindication for magnetic PNS, severe neurological disorders, pregnancy, current use of continuous neuromuscular blocking agents at the time of the study procedure, P/F ratio \<120, unstable hemodynamics (2 vasopressors), monitored ICP.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation

Contacts and locations

Locations

  • St. Michael's Hospital

    Toronto, Ontario, Canada

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