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Could less epinephrine save more lives in cardiac arrest?

NCT ID NCT03826524

Disease control Sponsor: Unity Health Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to hospital discharge.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epinephrine (Adrenaline)
What this could lead to
If successful, this could show that using less epinephrine during cardiac arrest is just as effective, potentially reducing side effects and improving survival.
What could go wrong
This is a Phase 4 trial, but results may not apply to all cardiac arrest cases. Lower doses might be less effective in some patients, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 3,790 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Out-of-hospital cardiac arrest treated by paramedics * Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire) * Established intravenous vascular access Exclusion Criteria: * Known or apparent age \<18 years * Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics * Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.) * Administration of intramuscular, endotracheal tube, or intraosseous epinephrine * Prisoners or persons in police custody * Known allergy or sensitivity to epinephrine

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Conditions

The condition(s) this trial relates to.

cardiac arrest Death, Sudden, Cardiac Out-of-Hospital Cardiac Arrest sudden cardiac arrest ventricular fibrillation ventricular tachycardia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest, out-of-hospital Sudden cardiac arrest Ventricular fibrillation Ventricular tachycardia-pulseless

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • British Columbia Emergency Health Services (BCEHS)

    RECRUITING

    Victoria, British Columbia, V8W 9P1, Canada

  • Essex-Windsor Emergency Health Services

    RECRUITING

    Windsor, Ontario, N9A 1N6, Canada

  • Halton Region Paramedic Services

    RECRUITING

    Oakville, Ontario, L6M 3L1, Canada

  • Medavie Health Services West

    RECRUITING

    Saskatoon, Saskatchewan, S7J 4M2, Canada

  • Middlesex-London Paramedic Service

    RECRUITING

    London, Ontario, N6E 1R4, Canada

  • Ottawa Paramedic Services

    RECRUITING

    Ottawa, Ontario, K1H 1E2, Canada

  • Peel Regional Paramedic Services

    RECRUITING

    Brampton, Ontario, L6T 4B9, Canada

  • Superior North Emergency Medical Services

    RECRUITING

    Thunder Bay, Ontario, P7B 4X6, Canada

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