Sanofi

This study tested a single combination shot that aims to protect against both COVID-19 and the flu. About 980 adults aged 50 and older received either the combo vaccine, each vaccine alone, or a placebo. Researchers checked for side effects and measured immune responses over 12 m…

This study tested a new yellow fever vaccine called vYF to see if it is as safe as the current licensed vaccine (YF-VAX). A total of 640 healthy adults aged 18 to 60 received one shot of either vYF or YF-VAX. Researchers monitored side effects like pain, fever, and headache for a…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3. Healthy adults aged 18 to 49 received a single injection of one of several vaccine formulas. Researchers monitored side effects and measured anti…

This study tested different versions of an mRNA vaccine for RSV (a common respiratory virus) in 240 healthy adults aged 18 to 49. The goal was to check safety and how well the vaccines trigger an immune response. Each participant received one shot and was followed for about 6 mon…

This study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. It involved about 980 adults aged 50 and older in the United States. The main goal was to see if the combo vaccine is safe and triggers a strong immune response …

This study tested a single dose of a new meningococcal conjugate vaccine in 360 healthy people aged 2 to 55. The goal was to see if the new vaccine works as well as an existing vaccine at protecting against four types of meningococcal bacteria. Researchers measured immune respons…

This study tested a new pneumococcal vaccine (SP0202) in 750 healthy adults aged 50 to 84. The goal was to see how well it triggered an immune response and how safe it was compared to two existing vaccines (Prevnar 13 and Pneumovax 23). Participants received a single shot and wer…

This study tested the drug dupilumab in 25 adults with chronic sinusitis and nasal polyps that standard treatments couldn't control. Participants received injections for up to 52 weeks. The main goal was to see if polyp size shrank by at least 1 point on a 0-8 scale after 24 week…

This study tested whether adding the drug aflibercept to standard chemotherapy (docetaxel) could help people with advanced non-small cell lung cancer live longer. The trial included 913 patients whose cancer had worsened after initial platinum-based treatment. The main goal was t…

This study followed 305 Canadian patients aged 6 and older with moderate-to-severe atopic dermatitis (eczema) who were prescribed Dupixent as part of their routine care. Researchers measured how many patients saw at least a 75% improvement in their eczema symptoms after 6, 12, an…

This study tested a long-acting insulin called Insulin Glargine U300 in 570 Chinese adults with type 2 diabetes whose blood sugar was not well controlled. Some participants had never used insulin before, while others switched from another basal insulin. The main goal was to see h…

This study tested a drug called dupilumab in Japanese children aged 6 months to 18 years with moderate-to-severe eczema that was not controlled by standard treatments. Participants received either dupilumab or a placebo, along with topical steroids, for 16 weeks. The goal was to …

This study tested an experimental drug called SAR442168 against a placebo in 767 adults with primary progressive multiple sclerosis (PPMS). The goal was to see if the drug could delay worsening disability. Participants took the drug or placebo and were monitored for changes in mo…

This study tested an experimental drug called SAR441344 in 84 adults with primary Sjögren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. The goal was to see if the drug could reduce disease activity and improve symptoms over 12 weeks compared to a pla…

This study looked at how the medication dupilumab changes the skin barrier in 41 children aged 6 to 12 with moderate to severe eczema. Researchers measured water loss from the skin to see if the treatment helps repair the skin's protective layer. The goal was to understand how du…

This study gave sutimlimab to 7 adults with cold agglutinin disease (CAD) who had already completed earlier studies and still needed treatment. The goal was to keep providing the drug until it became commercially available in Japan. Researchers tracked side effects and serious he…

This study tested a new drug, lunsekimig, in 685 adults with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual asthma medications. The main goal was to see if lunsekimig could reduce the number of asthma attacks and improve …

This study tested a drug called sarilumab in 420 adults hospitalized with severe COVID-19. The goal was to see if it could speed up recovery and improve survival compared to a placebo. Unfortunately, the drug did not show a clear benefit for these patients.

This study followed 3 people with acid sphingomyelinase deficiency (ASMD) who had already completed earlier studies of the enzyme replacement therapy olipudase alfa. The goal was to monitor safety and side effects while providing the drug until it was officially covered in France…

This study tested a drug called dupilumab in 63 Chinese adults with chronic sinusitis and nasal polyps (growths in the nose). Participants received either dupilumab injections or a placebo, along with a standard nasal steroid spray, for 24 weeks. The main goal was to see if dupil…

This study compared two medications, dupilumab and omalizumab, in 360 adults with severe nasal polyps and asthma. The goal was to see which drug better shrinks polyps and improves sense of smell. Both are injected treatments that help control symptoms but do not cure the conditio…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that wasn't helped enough by creams or other treatments. The goal was to see if the drug could clear or nearly clear the skin and reduc…

This study tested a drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants received either the drug or a placebo as an inj…

This study looked at the long-term safety and effectiveness of the drug SAR442168 in 125 people with relapsing multiple sclerosis who had already completed a previous study. Participants continued taking the drug for up to 240 weeks. The main goal was to track side effects, and t…

This study tested a drug called itepekimab in 312 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes chronic cough and infections. The goal was to see if it can reduce the number of moderate or severe lung infections (called exacerbations) over up to a y…

This study tested an experimental drug called SAR443122 in 68 hospitalized adults with severe COVID-19. The goal was to see if it could safely reduce dangerous inflammation and improve oxygen levels. Participants received either the drug or a placebo, and researchers measured cha…

This study tested the drug dupilumab in 109 adults with moderate to severe asthma that was not well controlled. The goal was to see if the drug could reduce lung inflammation and improve breathing, as measured by lung scans and breathing tests. Participants received either dupilu…

This study tested a new drug called SAR442970 in 86 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The goal was to see if the drug reduces inflammation and flare-ups better than a placebo. Participants received either…

This study tested a drug called dupilumab in people with chronic cold urticaria, a condition where cold exposure causes painful hives and itching. The 82 participants had not gotten relief from standard antihistamines. The goal was to see if dupilumab could prevent hives after an…

This study tested a new approach for people with a rare, life-threatening blood clotting disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP). Instead of the standard treatment of plasma exchange, participants received a combination of the drug caplacizumab …

This study tested whether adding the drug isatuximab to a standard two-drug regimen (carfilzomib and dexamethasone) helps people with multiple myeloma that has come back or stopped responding to treatment. 302 adults who had already tried 1 to 3 prior therapies took part. The mai…

This study tested a one-year course of the enzyme replacement drug imiglucerase at the highest approved dose in 12 Chinese patients with Gaucher disease type III. The goal was to see if it safely improves blood cell counts, reduces enlarged organs, and eases bone pain. Participan…

This study tested a new drug called SAR444245 combined with other cancer treatments in 138 adults with advanced gastrointestinal cancers, including esophageal, stomach, liver, and colorectal cancer. The goal was to see if the combination could shrink tumors. The study is complete…

This study tested a new drug called SAR442168 in 130 adults with relapsing multiple sclerosis (MS). The goal was to see if different doses could reduce new active brain lesions seen on MRI scans. The drug works by blocking a protein involved in immune system attacks on the brain.…

This study tested a drug called caplacizumab in 21 Japanese adults with acquired thrombotic thrombocytopenic purpura (aTTP), a rare condition causing dangerous blood clots. The goal was to see if the drug could prevent the disease from coming back. Participants received caplacizu…

This study looked at how dupilumab affects the skin barrier in 44 Chinese patients with moderate to severe atopic dermatitis (eczema). Over 16 weeks, researchers measured water loss from the skin to see if the treatment helped strengthen the barrier. The goal was to understand ho…

This study tested a long-acting insulin called Gla-300 in 228 adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. Participants had never used insulin before. The main goal was to check safety, including side effects and low blood sugar event…

This study looked at the long-term safety of dupilumab in 378 children with asthma who had already taken the drug in a previous study. The main goal was to track side effects over one year. A smaller part of the study in Japan also checked how well the drug improved lung function…

This study tested whether a stronger version of insulin lispro (200 units per mL) works the same as the standard version (100 units per mL) in people with type 1 diabetes. Ninety adults received a single dose of each insulin in random order, and researchers measured how the body …

This early-stage study tested an experimental drug called MRT5005, given as a mist through a nebulizer, in 42 adults with cystic fibrosis. The main goal was to check if the treatment is safe and tolerable. Researchers also looked at whether it could improve lung function. The stu…

This study tested two injectable diabetes drugs, iGlarLixi and IDegAsp, in 582 Chinese adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. The goal was to see which drug worked better at lowering blood sugar over 24 weeks. Both drugs are des…

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD, a serious lung disease often caused by smoking. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants were fo…

This study tested two daily doses (150mg and 300mg) of the drug vandetanib in 81 adults with advanced medullary thyroid cancer that could not be removed by surgery. The goal was to see which dose better shrinks tumors and controls the disease, while also tracking side effects. Pa…

This study tested a single pill combining two cholesterol-lowering drugs (ezetimibe and rosuvastatin) against rosuvastatin alone in 305 Chinese adults whose high cholesterol was not well controlled by statins. After 8 weeks, the combo pill was more effective at lowering LDL (bad)…

This study tested a new drug called SAR441566 in 221 adults with moderate to severe plaque psoriasis. The goal was to see if it could reduce skin symptoms like redness, thickness, and scaling. Participants took the drug or a placebo for 12 weeks, and doctors measured how much the…

This study tested an oral medication called eliglustat in 57 children aged 2 to 18 with Gaucher disease types 1 and 3. The goal was to see if the drug is safe and works well, either alone or with another treatment (imiglucerase). Researchers measured drug levels in the blood, sid…

This study looked at how dupilumab, a medication for moderate to severe eczema, improves the skin's barrier function. Researchers measured water loss from the skin in 52 participants before and after treatment. The goal was to understand how well the drug helps restore the skin's…

This study tested a combination of two drugs, plerixafor and G-CSF, to improve the collection of stem cells for transplant in 53 adults with multiple myeloma. The goal was to see if this approach could collect enough healthy stem cells in fewer sessions. The results help doctors …

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that didn't get better with creams. Participants also used standard steroid creams during the trial. The goal was to see if the shot co…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't helped enough by creams or other treatments. About 589 participants received either the study drug or a…

This study tested a cancer drug called isatuximab given either as a shot under the skin or through an IV, along with two other medicines (pomalidomide and dexamethasone), in 56 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goal…

This study looked at how dupilumab, a drug for moderate-to-severe eczema, changes nerve fibers in the skin and reduces itching. 54 adults with chronic itch took part. Researchers took skin samples to measure nerve density and branching before and after treatment.

This study looked at whether Soliqua 100/33, a combination insulin, can help people with very uncontrolled type 2 diabetes (HbA1c 9% or higher) spend more time in a healthy blood sugar range. 124 adults who were already on at least two diabetes pills took part. They used a contin…

This early-stage study tested a new drug called SAR442085 in 37 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goals were to find a safe dose and check for early signs that the drug can shrink or control the cancer. The study is…

This study tested a drug called dupilumab in 62 people with allergic fungal rhinosinusitis, a condition where fungus causes severe sinus inflammation. The goal was to see if the drug could reduce sinus blockage seen on CT scans and improve symptoms like congestion and sense of sm…

This study tested a new drug called amlitelimab in 437 adults with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual asthma medications. The main goal was to see if amlitelimab could reduce the number of severe asthma attack…

This study tested a new drug called lunsekimig in 79 adults with chronic sinusitis and nasal polyps that didn't improve with standard nasal sprays. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The goal was to see if the drug could shri…

This study followed 112 adults with severe asthma who started taking dupilumab (Dupixent®) to see how their quality of life changed over a year. Researchers measured breathing, activity, and emotional well-being using a standard questionnaire. The goal was to understand the drug'…

This study tested a new medication called lunsekimig in 150 adults with moderate-to-severe atopic dermatitis (eczema) who did not get enough relief from topical treatments. Participants received one of three doses of the drug or a placebo as a shot under the skin for 24 weeks. Th…

This study tested the drug dupilumab in 160 adults with prurigo nodularis, a condition causing intensely itchy skin bumps. Participants had severe itch that topical creams couldn't control. The goal was to see if dupilumab could reduce itch and clear skin lesions better than a pl…

This study tested whether increasing the infusion rate of Fabrazyme, a lifelong enzyme replacement therapy for Fabry disease, is safe and tolerable. Eight participants who had been on Fabrazyme for at least 3 months without infusion reactions received faster infusions with less f…

This study tested whether dupilumab, an injectable drug, improves sleep in 188 adults with moderate to severe eczema who also had trouble sleeping. Participants received either dupilumab or a placebo for 12 weeks. The main goal was to see if sleep quality ratings improved, with s…

This early-stage study tested a single injection of a new drug (SAR446959) in 32 people aged 45-65 with knee osteoarthritis. The main goal was to check safety and how the drug moves in the body, not to measure pain relief. Participants were monitored for about 6 months after the …

This early-stage study tested an oral medication called SAR441566 in 38 adults with mild to moderate psoriasis. The goal was to check safety and see if the drug improves skin symptoms over 4 weeks compared to a placebo. Participants were randomly assigned to receive either the dr…

This study tested the drug dupilumab in 151 adults with prurigo nodularis, a skin condition causing intense itching and bumps. Participants had severe itch that topical treatments couldn't control. The goal was to see if dupilumab could reduce itch and clear skin lesions. Results…

This study tested a fixed-dose combination of fexofenadine and pseudoephedrine (Allegra D) in 203 Indian participants aged 12 and older with allergic rhinitis. The goal was to check safety and how well it relieves nasal and other allergy symptoms over 13 days. Participants took t…

This early-stage study tested a new drug called SAR443765 in 36 people to see if it is safe and how the body processes it. Healthy adults received single or multiple doses, while people with mild-to-moderate asthma received a single dose. The goal was to check for side effects an…

This study looked at how dupilumab works in children aged 2 to 12 with chronic spontaneous urticaria (CSU), a condition causing itchy hives and swelling that doesn't get better with standard allergy medicines. Fifteen children received dupilumab injections for 24 weeks, and resea…

This study tested a special infrared patch (FIRTECH) for people with mild to moderate acute low back pain. 221 adults used the patch to see if it reduced pain and improved movement over 5 days. The goal was to find a drug-free way to ease back pain safely.

This study looked at whether a special patient outreach program could help people with advanced medullary thyroid cancer spend less time dealing with moderate to severe side effects from the drug vandetanib. About 205 adults took part. The program provided extra support to help m…

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18-55 who received a single dose under the skin. The main goal was to compare drug levels in the blood and check for any sa…

This early-stage study tested a single dose of a new drug called SAR441255 in 48 healthy adults who were lean to overweight. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked at how it affects blood sugar levels. This study does…

This study used health insurance records from over 81,000 German adults aged 14 to 44 to track chlamydia infections and their complications over 14 years. Researchers measured how often people got reinfected, developed problems like pelvic inflammatory disease or infertility, and…

This study tested a new drug called efanesoctocog alfa in 13 adults with severe hemophilia A. The goal was to see how long it stays active in the body compared to standard clotting factor drugs. Participants received a single injection of each drug in a fixed order, and researche…

This early-stage study tested a new oral drug called SAR441566 in 10 healthy Japanese men to see how the body processes it and if it is safe. The drug is being developed for rheumatoid arthritis, but this study did not treat the disease. Participants took single increasing doses …

This study looked at how healthy men process a single dose of an experimental drug for multiple sclerosis. Six men took a radioactive-labeled version of the drug so researchers could measure how much left the body in urine and stool, and how the drug was broken down. The main goa…

This study tested how a single 1200 mg dose of fexinidazole is handled by the body in people with mild or moderate liver impairment compared to those with normal liver function. 21 adults took part to measure drug levels and safety. The goal was to understand if liver problems ch…

This study looked at how a drug called SAR439859, being tested for breast cancer, is absorbed, broken down, and removed from the body. Six healthy postmenopausal women took a single dose with a radioactive tracer. The goal was to understand the drug's metabolism and bioavailabili…

This study looked at how two common drugs, gemfibrozil and rifampicin, change the way the body processes a potential multiple sclerosis medicine called SAR442168. Thirty healthy men aged 18 to 45 took part. The goal was to gather safety and drug-level information, not to treat an…

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body processes each version and whether they are safe and well-tolerated. Participants received a single injection and were monitored …

This study looked at whether safety information about the epilepsy drug Depakine (sodium valproate) is reaching doctors and pharmacists in Saudi Arabia. Researchers surveyed 455 healthcare professionals to see if they read the materials and know how to use the drug safely. No pat…

This early-stage study tested a new investigational drug, SAR444336, in 76 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo as a single dose or repeated doses. The goal was to gather safety information before test…

This study checked whether a new oral drug for rheumatoid arthritis, SAR441566, makes healthy adults more sensitive to sunlight or UV light. Sixty participants aged 18 to 55 received either the drug, a placebo, or a known sun-sensitizing antibiotic. Researchers measured skin redn…

This study tested the drug itepekimab in 49 adults aged 40 to 70 with COPD who were either former or current smokers. The goal was to see how the drug works on airway inflammation, not to cure or treat the disease. Participants stayed on their usual COPD medications during the 12…

This study looked at how well vaccines work in adults with moderate-to-severe eczema who are taking the drug amlitelimab. 224 participants received either amlitelimab or a placebo, along with tetanus and pneumonia vaccines. The goal was to see if the drug changes the body's immun…

This study checked 60 children with unexplained spleen enlargement to see how many had Gaucher disease or other rare conditions. Researchers looked at medical history and tests to find the cause. The goal was to better understand why some children have enlarged spleens without a …

This study looked at how the drug venglustat behaves in people with different levels of liver function. 26 adults with mild, moderate, or severe liver impairment, plus healthy volunteers, received a single dose. Researchers measured drug levels in the blood and monitored safety t…

This study asked over 1,000 adults in the U.S. about their experience after receiving a trivalent recombinant flu vaccine. Participants completed a 30-minute online survey about side effects, pain, and how the shot affected their daily life. The goal was to better understand vacc…

This study tested how well two different tablet forms of the drug rilzabrutinib are absorbed by the body, and whether food changes that absorption. 28 healthy adults aged 18-55 took single doses of each tablet form in random order. The goal was to gather information, not to treat…

This study looked at how chronic immune thrombocytopenia (ITP) affects thinking skills and fatigue in adults. Researchers measured cognitive function and inflammation markers in 97 patients using blood tests and computer-based assessments. The goal was to better understand the li…

This study looked at 82 Chinese adults with multiple sclerosis to see if a specific gene change (ABCG2 mutation) affects how the body processes the drug teriflunomide. Participants took the drug daily for 24 weeks, and researchers measured drug levels and tracked side effects lik…

This study tested whether a new version of the drug dupilumab works the same as the current version in healthy adults aged 18 to 65. Participants received a single injection of either the new or current drug, and researchers measured drug levels in the blood and checked for side …

This study looked at how a new medicine called amlitelimab affects the way the body processes other drugs in adults with moderate-to-severe atopic dermatitis (eczema). 23 participants took part. The goal was to understand potential drug interactions to ensure safe use with other …

This early-stage study tested the safety and tolerability of a new drug, SAR441344, in 56 healthy adults. Participants received either the drug or a placebo through an IV or injection. The main goal was to see if the drug caused any side effects, not to treat any disease.