ITP study reveals hidden toll on brain and body
NCT ID NCT06665308
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how chronic immune thrombocytopenia (ITP) affects thinking skills and fatigue in adults. Researchers measured brain function and inflammation using blood tests and questionnaires in 97 patients. The goal was to better understand these connections, not to test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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97 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Nov 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The source population for this study will be patients treated for primary chronic Immune Thrombocytopenia at one of the four study centers in two countries (3 centers in the USA, 1 center in the UK).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient diagnosed with chronic (ITP with \> 1 year duration) primary ITP living in the USA or the UK: * On ITP pharmacologic treatment, , including on-demand treatment strategy, regardless of last platelet count (below or above 100 x 10\^9 counts/L); * Patients with their most recent platelet count \>50 x 109 counts/L) and without any ITP-specific treatment for 1 year or less. * Adult patient who are 18 years or older at index date * Patient who has received at least one initial first line ITP therapy (CS/ IVIg/ANTI d) with initial response as of index date and indicated by one of the following: * Platelet count ≥ 50 x 10\^9 counts /L; OR * Platelet count ≥ 30 x 10\^9 counts /L with at least a two-fold increase from baseline within 1 month since start of treatment, as per ASH 2019 guidelines; OR * A medical record of initial response as determined by clinical judgement, considering documented platelet count along with overall patient condition and relevant medical factors. * Patients whose medical history related to the study objectives are available from the site covering 12 months prior to index date. * Patient provided informed consent to participate in the study. Exclusion Criteria: * Secondary ITP. * Patients with their most recent platelet count \>50 x 10\^9 counts/L and without any ITP-specific treatment for more than 1 year. * Patients with recent or active infection recorded 14 days or less before index date; patients with uncontrolled chronic infections or who were recently diagnosed with a chronic infection (≤14 days of index date). * Patients with vaccination in 28 days before index date. * Patients treated with rilzabrutinib on or before index date. * Patients who participated in an interventional clinical trial for any investigational drug in the 180 days prior to index date.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Investigational Site Number: 8260001
London, London, City of, W12 0HS, United Kingdom
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Massachusetts General Hospital- Site Number : 8400001
Boston, Massachusetts, 02114, United States
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USC Norris Comprehensive Cancer Center- Site Number : 8400002
Los Angeles, California, 90033, United States
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University of Washington-Fred Hutchinson Cancer Center_Site Number: 8400003
Seattle, Washington, 98109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- What Trade-Offs are ITP patients willing to make for better treatment?
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- New combo therapy aims to boost platelets in immune disorder
- Engineered immune cells take on rare blood disorders
- Can a vitamin a drug boost platelets in Hard-to-Treat ITP?