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New hope for rare blood disorder: drug cuts recurrence risk in japanese patients

NCT ID NCT04074187

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 23 times

Summary

This study tested a drug called caplacizumab in 21 Japanese adults with acquired thrombotic thrombocytopenic purpura (aTTP), a rare condition causing dangerous blood clots. The goal was to see if the drug could prevent the disease from coming back. Participants received caplacizumab alongside standard plasma exchange treatment. The study found that the drug helped reduce recurrence and improve platelet counts, but patients may still need ongoing management.

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Contacts and locations

Locations

  • Investigational Site Number 3920001

    Kitakyushu-Shi, Japan

  • Investigational Site Number 3920002

    Kumamoto, Japan

  • Investigational Site Number 3920003

    Kurashiki-Shi, Japan

  • Investigational Site Number 3920005

    Maebashi, Japan

  • Investigational Site Number 3920006

    Sendai, Japan

  • Investigational Site Number 3920007

    Kashihara-shi, Japan

  • Investigational Site Number 3920009

    Iruma-Gun, Japan

  • Investigational Site Number 3920010

    Kyoto, Japan

  • Investigational Site Number 3920011

    Osaka, Japan

  • Investigational Site Number 3920013

    Kawasaki-Shi, Japan

  • Investigational Site Number 3920014

    Kanazawa, Japan

  • Investigational Site Number 3920015

    Nagoya, Japan

Conditions

Explore the condition pages connected to this study.