Poznan University Of Medical Sciences

This study tests whether using a breath measure called respiratory quotient (RQ) can help doctors give the right amount of calories to ICU patients on breathing machines. About 200 adults will be randomly assigned to standard nutrition care or care that also adjusts food based on…

This study tests whether measuring drug levels in the blood can help doctors give the right dose of common antidepressants (sertraline or escitalopram) to hospitalized children and adults with major depression. About 180 participants will receive personalized dosing based on thes…

This study tests a special software that predicts when a patient's blood pressure might drop dangerously low during major aortic surgery. The goal is to help doctors act faster to prevent complications like kidney or heart injury. About 200 adults scheduled for elective aortic su…

This study tests two ways to numb the shoulder for surgery. The standard method can weaken the diaphragm, making breathing harder. The new method combines two different nerve blocks to try to avoid that problem. About 70 people having shoulder surgery will be randomly assigned to…

This study looks at whether adding a PENG nerve block to standard spinal anesthesia can lower the chance of postoperative delirium (sudden confusion) in adults aged 75 and older having hip replacement surgery. About 180 participants will be randomly assigned to receive either spi…

This study tests whether adding dexamethasone or dexmedetomidine to standard numbing medicine can reduce the need for strong painkillers after knee replacement. About 96 older adults will be randomly assigned to one of three groups to compare pain relief and side effects. The goa…

This study tests two types of nerve blocks to see which one controls pain better after hip replacement surgery. About 90 adults aged 65 and older will receive either a PENG block or a combination of ESPB blocks before surgery. The goal is to reduce the need for strong painkillers…

This study tests two different ways to numb the knee after total knee replacement surgery. Both methods use a standard block for the front of the thigh, then add either a block near the tailbone or a block behind the knee. The goal is to find which combination provides longer pai…

This study compares three types of nerve blocks to see which provides the best pain relief after hip replacement while preserving leg strength for early walking. About 93 adults aged 65 and older will receive one of the blocks during surgery. The goal is to find the safest and mo…

This study looks at whether giving dexamethasone near the nerves or through a vein is safe and works well for pain relief in children having hand or forearm surgery. About 150 kids aged 3 months to 16 years will take part. Researchers will check for nerve problems and measure pai…

This study looks at whether adding a small dose of dexmedetomidine to a standard nerve block can provide longer-lasting pain relief after hip surgery in adults 65 and older. Participants will be randomly assigned to receive either the standard block or the block with the added me…

This study looks at whether injecting the anti-inflammatory drug dexamethasone into a nerve block or into a vein works better for pain and swelling after total knee replacement. About 90 adults having knee surgery will be randomly assigned to one of the two methods. Researchers w…

This study compares three types of a nerve block (PENG block) for pain after hip surgery in people aged 65 and older. All participants get the standard block, but some also receive either dexamethasone or dexmedetomidine near the nerves to see if these additives extend pain relie…

This study compares two medications, dexamethasone and dexmedetomidine, added to a standard nerve block for pain after lower back surgery. 150 adults having elective lumbar spine surgery will receive one of the two additives along with a local anesthetic. The goal is to see which…

This study compares three versions of a nerve block (PENG block) in 120 adults aged 65 and older having hip surgery. All patients get the same base painkiller, but some also receive extra medications near the nerves or through a vein. The goal is to find which combination provide…

This study looks at whether adding certain medications to a standard nerve block can help children feel less pain after foot or ankle surgery. About 120 children aged 3 to 12 will receive a nerve block with one of three added medications. The goal is to see which approach provide…

This study looks at whether giving the anti-inflammatory drug dexamethasone through a vein or near the nerves works better for controlling pain after arm or hand surgery in children. Ninety kids weighing more than 5 kilograms will take part. The goal is to find the best method to…

This study follows 1,500 twins aged 15 to 44 over five years to learn how metabolic syndrome and related liver problems develop. Researchers will track new cases of fatty liver disease, fibrosis, and cirrhosis, and look at how genes, environment, and gut bacteria affect these con…