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Can a sedative calm the Body's surgical storm?

NCT ID NCT07743853

Symptom relief Sponsor: Poznan University of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial tests whether giving the sedative dexmedetomidine during hip replacement surgery can dampen the body's stress and inflammatory response to the operation. Researchers will compare two doses of the drug against a placebo in 90 adults aged 50-90 undergoing total hip arthroplasty. The goal is to see if it reduces inflammation, pain, and opioid use, and improves overall recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine, a sedative drug given intravenously during surgery
What this could lead to
If effective, this could point to a simple way to reduce post-surgical inflammation, pain, and opioid use, speeding up recovery after hip replacement.
What could go wrong
This is a small, early-stage trial, and the results may not apply to all patients. Dexmedetomidine can cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 50-90 years. * Scheduled for elective primary total hip arthroplasty due to primary hip osteoarthritis. * American Society of Anesthesiologists (ASA) physical status I-III. * Planned spinal anesthesia combined with ultrasound-guided Pericapsular Nerve Group (PENG) block. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Refusal to participate or inability to provide written informed consent. * Contraindications to spinal anesthesia. * Contraindications to PENG block. * Allergy or hypersensitivity to dexmedetomidine, ropivacaine, bupivacaine, or study medications. * Second- or third-degree atrioventricular block without a permanent pacemaker. * Resting heart rate \<50 beats/min. * Severe hepatic impairment (Child-Pugh class C). * Severe renal failure requiring dialysis. * Chronic opioid therapy (\>3 months before surgery). * Chronic treatment with α2-adrenergic agonists. * Cognitive impairment or inability to complete postoperative questionnaires. * Infection at the injection site. * Coagulopathy or ongoing anticoagulation precluding neuraxial anesthesia according to current guidelines. * Revision total hip arthroplasty. * Simultaneous bilateral total hip arthroplasty. * Participation in another interventional clinical trial within the previous 30 days.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hip

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Poznan University of Medical Sciences

    Poznan, 62-701, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.