Ohio State University Comprehensive Cancer Center

This early-stage trial tests a vaccine (OSU-2131) designed to help the immune system fight Epstein-Barr virus (EBV), which can cause cancer in people with weakened immunity. The study includes healthy volunteers and patients waiting for a solid organ transplant, who are at higher…

This study tests a multi-level smoking cessation program designed for high-risk women in rural Appalachia. The program helps doctors and clinics identify smokers, offer counseling, and connect them to support. Researchers will measure how well the program works by tracking quit r…

This study tests whether adding venetoclax to ibrutinib can eliminate genetic mutations that make chronic lymphocytic leukemia (CLL) resistant to ibrutinib. About 28 adults with CLL who already have these resistance mutations will receive both drugs for 12 cycles. The goal is to …

This study tests a combination of two drugs, ibrutinib and nivolumab, in adults with classical Hodgkin lymphoma that has come back or not responded to prior therapy. The goal is to see if this combination can shrink or control the cancer. About 18 participants will receive both d…

This early-phase trial tests whether adding papaverine (a drug that relaxes blood vessels) to precise, high-dose radiation therapy is safe and helps control non-small cell lung cancer or lung tumors that have spread from other cancers. About 19 adults with tumors 5 cm or smaller …

This study tests whether giving a single, strong dose of radiation directly to the tumor site during breast-conserving surgery (with reconstruction) is safe and effective for women with early-stage breast cancer. About 108 participants will receive this targeted radiation boost r…

This study tests whether an educational program for parents and healthcare providers can increase HPV vaccination rates among girls aged 9 to 17 in Ohio Appalachia. About 624 parents and providers are involved. The goal is to see if learning more about the vaccine leads to more g…

This study tests whether a patient navigation program helps women at high risk for breast cancer make informed decisions about risk management, like screenings or preventive steps. About 75 women with a family history of breast cancer but no personal diagnosis will receive guidan…

This early-stage study tests whether black raspberry confections can help prevent oral cancer in 67 healthy volunteers. Researchers will measure how the body absorbs berry compounds and how they affect genes linked to cancer and inflammation. Participants follow a berry-restricte…

This study tests a web-based portal called YES that helps young breast cancer survivors track symptoms and find resources. About 400 women aged 15-39 who had early-stage breast cancer will use the portal or get standard care. The goal is to see if the portal improves quality of l…

This study tests whether early visits with a neuropsychologist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with stage IV solid tumors and brain metastases will receive neuropsychological evaluat…

This small pilot study tested whether a robot-assisted surgical system (da Vinci) can safely perform nipple-sparing mastectomy in 4 women with early-stage breast cancer or those needing preventive mastectomy. The goal was to see if the robot could remove breast tissue completely …

This pilot study looks at whether a ketogenic (low-carb, high-fat) diet is practical and beneficial for 24 adults with brain metastases who are scheduled for radiosurgery. Participants will follow either a ketogenic or standard healthy diet for 16 weeks. Researchers will track di…

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…

This study looks at whether using suction during a lung biopsy (EBUS-TBNA) helps get better tissue samples from people with suspected lung cancer that has spread to lymph nodes. About 50 adults will take part. The goal is to see if suction increases the amount of tissue collected…

This study looks back at the results of robotic prostate surgery in over 1,500 men with prostate cancer. Researchers want to understand patient traits and how they relate to surgery outcomes, including cancer return and survival. The goal is to improve future treatment decisions.

This study looks at how vaping impacts lung function in young adults (ages 21-25) who are either obese or not. Researchers will measure breathing before and after a vaping session, and track vaping habits. The goal is to understand if obesity makes the lungs more vulnerable to e-…

This study tests a nanochip technology to see if it can better monitor how well treatment is working and detect if lymphoma comes back in people with diffuse large B-cell lymphoma. About 73 participants will provide blood samples during their standard chemotherapy. The goal is to…

This pilot study is testing whether changes in tumor DNA found in the blood can help doctors see if immunotherapy is working in patients with non-small cell lung cancer or kidney cancer. About 100 adults will give blood samples before and during their standard treatment. The goal…

This study aims to find genetic changes that increase the risk of papillary thyroid cancer, especially in families where the disease runs strong. Researchers will analyze DNA from 1,200 people, including those with and without cancer, to pinpoint risk-related genes. The goal is t…

This study looks at whether a 12-week virtual exercise program, combined with group counseling, can change the bacteria in the gut and reduce inflammation in smokers at high risk for lung cancer. About 65 people aged 50-77 who smoke or used to smoke will take part. The goal is to…

This study looks at how hormone therapy (anti-androgen treatment) for prostate cancer may affect the heart. Researchers will use heart MRI scans before and after 4-7 months of treatment in 23 men. The goal is to understand changes in heart function, which could help doctors plan …

This study follows 72 women with pelvic cancers (like cervical, rectal, or anal cancer) who are receiving radiation therapy. Researchers measure physical changes in the vagina and collect surveys about sexual function, intimacy, and quality of life before treatment and up to 2 ye…

This study looks at shoulder and arm problems in people with lymph-node positive breast cancer who receive radiation therapy. About 61 participants will be followed for one year after treatment to see how often shoulder issues occur with two different radiation techniques. The go…

This study looks at whether watching a short video can help people with metastatic cancer better understand tumor genomic testing. About 243 adults with advanced breast, lung, or other solid tumors will watch the video and answer questions before and after. The goal is to see if …

This study looks at how using e-cigarettes impacts the body, comparing 75 users with 75 non-users. Researchers measure lung and heart function to find early signs of harm. The goal is to give policymakers clear evidence to regulate tobacco products.

This study looks at how well different food frequency questionnaires estimate the amount of fruits and vegetables people eat. Researchers will compare the questionnaires to actual diet records and to levels of carotenoids (plant nutrients) in blood and skin. The study involves 10…

This study tests whether a genetic counseling program delivered through a hospital's online patient portal works as well as traditional in-person counseling for women at elevated risk for breast cancer. About 874 women will take part, and researchers will compare how well each gr…