Medical University Of South Carolina

This study tests a new way to deliver high-dose radiation for low- and intermediate-risk prostate cancer. The approach spares the urethra, rectum, and nearby arteries to reduce urinary and bowel side effects. About 42 men will receive this treatment and be followed for up to 2 ye…

This program gave patients with inherited mitochondrial diseases like Leigh syndrome continued access to the experimental drug vatiquinone after they finished a previous safety study. Only those who had already taken vatiquinone and could not join another trial were eligible. The…

This study tests whether a single infusion of stem cells from donated umbilical cord blood can safely preserve insulin-making cells in people recently diagnosed with type 1 diabetes. 60 adults aged 18-40 with new-onset diabetes will receive the cells and be monitored for a year. …

This study tests a program that trains pharmacists to help people living with HIV quit smoking. The program gives pharmacists tools and support to offer smoking cessation counseling and medications. Researchers will see if this approach helps more patients stop smoking and improv…

This study compares two laser treatments for open-angle glaucoma: the standard Selective Laser Trabeculoplasty (SLT) and a newer, automated Direct Selective Laser Trabeculoplasty (DSLT). About 51 adults with open-angle glaucoma or ocular hypertension will be randomly assigned to …

This study looks at whether switching completely from regular cigarettes to e-cigarettes can reduce harm for cancer patients who smoke but refuse standard quitting treatments. About 208 adults with cancer who smoke will be offered e-cigarettes and followed for 6 months to see if …

This study planned to test a device called the Globus Reflect Tether in children and teens with scoliosis who are still growing. The device was designed to hold the curved side of the spine so the other side could grow and straighten naturally. However, the study was withdrawn be…

This study tests whether a smartphone app, used with a pharmacist's help, can improve medication tracking, blood pressure, and blood sugar control in kidney transplant patients. The goal is to help African American patients have better long-term outcomes after transplant. About 1…

This study tests whether a daily cream containing rapamycin can help bring back skin color in people with vitiligo. Twenty participants apply the cream to one patch of skin and a placebo to another for six months. Doctors check for repigmentation and side effects.

This study tests a program called FIT Families, designed to help African American teenagers with obesity and their caregivers make healthier lifestyle changes together. The program is led by community health workers and is tailored to the families' needs. About 360 teens and thei…

This study tests an electronic visit (e-visit) to help adults aged 40 and older who smoke quit smoking and get screened for COPD. Participants are randomly assigned to receive the e-visit or not. The e-visit asks about smoking habits and symptoms, and may offer a prescription for…

This small pilot study tested a treatment for people with severe depression that did not improve with standard therapies. The approach involved surgically placing a thin wire on the surface of the brain's frontal area to deliver mild electrical pulses. The goal was to see if this…

This study looks at whether a therapy called RRFT, which treats both substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with trauma history and both conditions will be randomly assigned to RRFT or usual care. Rese…

This study looks at whether adding oxytocin (a natural hormone) to talk therapy helps veterans with both PTSD and alcohol use disorder. About 175 veterans will receive either oxytocin or a placebo along with therapy. The goal is to see if oxytocin reduces drinking and PTSD sympto…

This study tests whether citicoline, a common supplement, can reduce inflammation in the brain and improve thinking skills in 56 teens and young adults (ages 16-22) who drink alcohol. Participants take either citicoline or a placebo pill for a period, and researchers measure immu…

This study tests a new treatment called low-intensity focused ultrasound (LIFUP) for people with depression that hasn't improved with standard treatments. The ultrasound targets a small area deep in the brain linked to mood. The goal is to see if it is safe and can reduce depress…

This study looks at whether adding art therapy to physical therapy helps children aged 5 to 18 recover better after a stem cell transplant. Kids in the hospital receive either both therapies or physical therapy alone for two weeks. Researchers measure changes in walking, self-car…

This early-stage study tests whether a noninvasive technique called transcranial focused ultrasound (tFUS) can improve memory by gently stimulating the hippocampus, a key memory center. Researchers will enroll 25 adults aged 50-85 with mild memory problems or healthy aging. The g…

This study tests a new, short-term brain stimulation method called rTMS to help improve thinking problems in people who have had a stroke. Twenty adults with a chronic stroke will receive the treatment to see if it is safe and can boost brain activity and cognitive function. The …

This study is testing an accelerated version of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, to see how well it reduces symptoms of depression and anxiety. Researchers will treat 70 adults and track changes in mood using standar…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can reduce heavy drinking and improve thinking skills in older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Researchers will measure changes in dri…

This study adapts Written Exposure Therapy (WET), a brief 5-session therapy, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from teens and experts to tailor WET, then test it against the standard 12-16 session therapy in 48 teens. The goal is to see …

This study tests whether bright light therapy can help ease depression in adults aged 60 and older who are hospitalized for unipolar depression. Twenty participants will receive either bright light or a dim placebo light during their hospital stay. The goal is to see if this simp…

This study looks at whether blocking certain arteries in the knee with tiny particles (embolization) can reduce pain and the need for painkillers in people with knee osteoarthritis. Twelve adults with mild to moderate knee arthritis will get the procedure and be followed for a ye…

This study tests whether Qutenza 8% capsaicin patches can safely ease nerve-related lower back pain that may travel down the leg. About 50 adults with pain lasting over three months will receive up to four patches per visit over 12 months, alongside their usual care. The goal is …

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a state of confusion. Researchers will compare patients who get usual care with those who have overnight checks paused. The goal is to see if less sleep disruption lea…

This study tests whether giving radiation over just 5 days before surgery for soft tissue sarcoma is practical and acceptable. About 16 adults with sarcoma in an arm, leg, or trunk will receive this shorter radiation course. The goal is to see if patients choose this option and h…

This study tests whether texting pregnant women about mental health and substance use helps them get treatment faster and stick with it, compared to standard in-person screening. Over 10,000 pregnant women aged 18-45 at MUSC clinics will take online questionnaires. The goal is to…

This study tests a newer type of CT scanner (photon counting detector CT) alongside the standard PET-CT scan in 20 adults with head and neck cancer. The goal is to see if the new scanner produces clearer images that doctors trust more. Participants will not receive any direct ben…

This study looks at whether a non-invasive device that temporarily changes brain activity (called rTMS) can affect how healthy adults make decisions. It involves two 2-3 hour visits and uses questionnaires to measure impulsiveness. The study is not a treatment—it aims to gather k…

This study measures lead levels in the bones of 500 psychiatric patients to see if past lead exposure makes mental illness worse or changes how well brain treatments like TMS or EEG work. Participants are adults aged 18-70 already enrolled in other hospital studies. The goal is t…

This study planned to use focused ultrasound—sound waves aimed at a tiny brain area called the centromedian nucleus—to see if it could improve alertness and reaction time in healthy adults aged 22 to 55. The goal was to measure changes in brain waves and reaction speed. However, …

This study looks at whether a special alert in the electronic health record can help doctors prescribe nicotine replacement therapy (like patches or gum) to hospitalized smokers. About 220 patients and their resident doctors will take part. The goal is to see if the alert increas…

This study was designed to see if personalized brain stimulation could improve working memory in healthy adults aged 50 to 85. Researchers planned to test different stimulation settings and measure brain activity changes. However, the study was withdrawn before enrolling any part…

This study looks at how the brain changes old movement habits, like a bad golf swing or piano technique. Researchers will use EEG to measure brain activity and apply gentle electrical stimulation to see if it helps people learn a new movement. The study involves 30 healthy adults…

This study uses MRI scans to track brain changes in 40 adults with major depressive disorder who are receiving transcranial magnetic stimulation (TMS) therapy. Participants will have three MRI scans over six weeks to monitor how the brain responds to treatment. The goal is to bet…

This study aimed to see if customizing the dose of a gentle brain stimulation technique (tDCS) could improve its effects on movement. It planned to include healthy people and stroke survivors, but the study was withdrawn before any participants were enrolled. No results are avail…