Medical University Of South Carolina

This study tests whether a natural supplement called oleoylethanolamide (OEA) can reduce inflammation, improve thinking, and lower alcohol use in young adults aged 18–25 with alcohol use disorder. Over 6 weeks, 42 participants will take either OEA or a placebo and provide blood, …

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This study tests whether taking progesterone (a natural hormone) early in pregnancy can prevent preeclampsia, a serious condition causing high blood pressure. About 642 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. The goal is to see i…

This study tests a new approach to delivering the SafeCare program, which helps parents prevent child maltreatment. Researchers will work with 12 home visiting providers and 40 caregivers to see if a mix of in-person and virtual sessions can reach more families and improve parent…

This small pilot study will test whether adding brief guided mindfulness meditation (using a smartphone app) to standard accelerated brain stimulation therapy can help ease depression symptoms. Twenty adults with major depression who are already scheduled for brain stimulation wi…

This study tests a program called LiveWell, which teaches emotional coping skills to people with metastatic lung cancer who feel distressed. About 80 participants will either take the program or receive usual care. The goal is to see if LiveWell can reduce anxiety and depression …

This early study tests whether a topical minocycline foam (AMZEEQ®) can safely improve the appearance and symptoms of confluent and reticulated papillomatosis (CARP), a rare skin condition that causes brown, scaly patches. About 35 people aged 9 and older will apply the foam to o…

This early-stage study tests whether a special probiotic capsule can treat moderate to severe acne in 34 adults aged 18 to 45. The capsule contains five types of bacteria thought to improve gut health, reduce inflammation, and possibly lower blood sugar spikes linked to acne. Res…

This early study tests whether a device that gently stimulates a nerve in the ear (taVNS) can be used safely at home to help with Parkinson's symptoms like walking and balance problems. Sixteen adults with Parkinson's will use the device for one hour each day over eight weeks. Re…

This early-stage study tests whether a non-invasive ultrasound technique, called low intensity focused ultrasound (LIFU), can safely improve social and brain function in 20 people aged 13–25 with autism. Participants receive personalized, image-guided ultrasound pulses to a deep …

This early-stage study tests whether transcranial magnetic stimulation (TMS) can reduce chronic scrotal content pain in men. Fifty men who have had pain for at least six months will receive TMS and report their pain and quality of life daily via text messages. The goal is to see …

This study tests a group therapy program called LiveWell mBC, based on dialectical behavioral therapy (DBT), for women with metastatic breast cancer who feel distressed. About 48 women will either join the program or receive usual care. The goal is to see if the program is practi…

This study tests whether taking steroids after sleep surgery helps adults with obstructive sleep apnea feel less pain, eat normally sooner, and use fewer painkillers. About 120 adults will receive either steroids or a placebo for a short time after their operation. The goal is to…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers across three clinics will use the toolkit during rout…

This study will use brain scans (EEG and fMRI) to watch how healthy older adults' brains keep and update memories. Researchers want to find out which brain patterns help people stay sharp as they age. The study involves 40 healthy adults, most aged 60 or older, doing a simple com…

This study looks at how teenagers who have experienced trauma respond to stress and strong emotions. Researchers will measure brain activity, heart rate, and sweat responses while teens imagine a stressful event. The goal is to better understand PTSD in adolescents and find out w…

This study will test a non-invasive technique called focused ultrasound on the brains of 25 healthy adults aged 18-55. Researchers want to see how it changes brain signals and chemical levels. The goal is to understand how the method works and if it is safe, not to treat any dise…

This pilot study looks at how cold-water immersion, sauna use, or both together affect sleep quality and brain waste removal in 45 military cadets. Participants will wear a smart ring and a brain monitor to track sleep and body changes. The goal is to see if these temperature the…