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Scientists scan brains of older adults to unlock secrets of memory maintenance

NCT ID NCT06862622

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study will use EEG and fMRI brain scans to watch how healthy older adults' brains maintain memories while they perform a computer-based learning task. Researchers aim to identify patterns that show when the brain is working efficiently versus struggling. The findings could help distinguish normal aging from early signs of memory decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how the aging brain compensates for memory changes, pointing toward future ways to support memory health in older adults.
What could go wrong
This is an early observational study with only 40 participants. It does not test any treatment, so it cannot directly lead to a therapy. Results may not apply to people with memory disorders.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy volunteers aged18 years or older (80 of the final sample will be ≥60years of age).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older (80 of the final sample will be ≥60years of age) * Cognitively unimpaired, ambiguous, or mildly impaired cognitive function, defined as a score of ≥18 in the Montreal Cognitive Assessment (MOCA). * No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head * Ability to give consent for study participation * Ability to perform a computer task requiring responding to visual cues and typing on a standard computer keyboard with both index and middle fingers for 30 minutes daily. Exclusion Criteria: * Inability to use both index and middle fingers to type on a standard computer keyboard * Dementia defined as a score of \<18 in the Montreal Cognitive Assessment (MOCA) * Uncorrected vision, hindering perception of visual cues presented on a standard computer screen * Medication use at the time of study that may interfere with learning, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, and dextromethorphan. * Neuromuscular disorders that affect fine motor control of the hands. * Presence of neurological or psychiatric disorders * Presence of scalp injury or disease * Prior intracranial surgery * Prior brain radiotherapy * Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation * Metal in the head or neck * Contraindications to MRI (such as severe claustrophobia, implanted medical devices)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy older adults

How to take part

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  1. The official record

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    Open the record ↗

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