M.d. Anderson Cancer Center

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This phase 1 trial tests a new cell therapy called KITE-753 for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to standard treatments. KITE-753 is made from a patient's own immune cells, which are modified to recognize and attack leuke…

This phase 1 trial is testing whether combining the experimental drug zotatifin with the chemotherapy carboplatin can help people with advanced triple-negative breast cancer (TNBC) that has not responded to standard treatments. The study aims to find the safest and most effective…

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…

This study tests whether using the Provox ActiValve voice prosthesis as a first choice can reduce the number of times the device needs to be replaced each year in people who have had their voice box removed (laryngectomy) and have a tracheoesophageal puncture (TEP). The trial wil…

This phase II trial is testing whether combining the experimental immunotherapy drug ivonescimab with chemotherapy (paclitaxel) delivered directly into the abdomen can safely and effectively treat people with high-grade metastatic appendiceal adenocarcinoma that cannot be removed…

This study tests adding ropeginterferon alfa-2b to the standard drug azacitidine for people newly diagnosed with a type of blood cancer (MDS or AML) that has a specific genetic change called a TP53 mutation. The goal is to find the safest dose of the combination and see if it can…

This phase 2 trial is testing two oral drugs, BGB-16673 and sonrotoclax, in 40 people with untreated chronic lymphocytic leukemia (CLL). The goal is to see if this combination can safely control the disease for a limited time, potentially reducing the need for ongoing therapy. Pa…

This phase 2 trial compares two approaches for people with untreated, low-tumor-burden follicular lymphoma: receiving the investigational drug epcoritamab or being closely monitored without treatment. The goal is to see if epcoritamab can extend the time before standard treatment…

This study tests an oral chemotherapy drug, cladribine, combined with two other drugs (low-dose cytarabine and venetoclax) in people with acute myeloid leukemia (AML). The first part finds the safest dose; the second part checks if that dose helps control the disease. About 58 ad…

This phase 2 trial is testing an experimental drug called LX-101 to see if it can help control Ewing sarcoma and related tumors (DSRCT and SRCS) that have come back or stopped responding to standard chemotherapy. The study enrolls adolescents and young adults (age 10 and up) who …

This early-stage trial is testing an experimental drug called monzosertib in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has returned or not responded to standard treatment. The main goal is to find a safe and recommended dose of monz…

This Phase 2 trial tests a new treatment for aggressive T-cell blood cancers. Patients receive specially engineered natural killer (NK) cells from donated cord blood, along with chemotherapy, to try to keep the cancer in remission. The study will enroll 70 adults aged 18-80 whose…

This early-phase trial tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) plus a targeted drug called T-Dxd. The study aims to find the safest dose …

This study tests a combination of seven drugs (including asciminib and venetoclax) in 30 adults with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute myeloid leukemia. The first phase checks safety, and the second phase sees if the combo helps control t…

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This study tests whether a drug called blinatumomab, given as a simple injection under the skin, can control small amounts of leftover leukemia cells (called measurable residual disease, or MRD) in adults with B-cell acute lymphoblastic leukemia. The goal is to prevent the cancer…

This early-phase trial tests whether immune cells (CD8+ T cells) given through a spinal tap are safe for people with melanoma that has spread to the lining of the brain. Only 8 participants will receive the treatment. The main goal is to check for side effects, not to cure the di…

This phase 2 study tests the drug zanzalintinib in 16 adults with recurrent or metastatic olfactory neuroblastoma, a rare cancer of the nasal cavity. The goal is to see if the drug can help control the disease and to check its safety. Participants must not have had prior treatmen…

This early-phase study tests two drugs, blinatumomab and revumenib, given together to adults with a rare and aggressive form of acute lymphoblastic leukemia (ALL) that has a specific genetic change called KMT2A rearrangement. The main goal is to find a safe dose and understand si…

This early-phase trial tests a new treatment for stomach cancer that has spread to the lining of the abdomen. Ten adults will receive specially engineered immune cells (NK cells) infused directly into the abdomen, along with standard chemotherapy drugs. The main goals are to find…

This study tests a virus called G207 combined with a small dose of radiation in children whose high-grade glioma has come back or is growing. The goal is to see if the treatment is safe and helps control the tumor. About 38 children will take part.

This study tests whether a combination of two drugs, zanzalintinib and cemiplimab, can help people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer live longer. The goal is to extend average survival by about 4 months. The trial will include 12 adults …

This study tests a new treatment called CD70.CAR NK cells for people with diffuse large B-cell lymphoma or Hodgkin lymphoma that did not respond to or came back quickly after initial therapy. The treatment uses specially designed immune cells from a donor to find and attack cance…

This phase 2 trial is testing whether a combination of three drugs—zanubrutinib, sonrotoclax, and obinutuzumab—can safely control chronic lymphocytic leukemia (CLL) in people who have not yet received treatment. About 40 participants will receive all three drugs orally. The main …

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…

This early-phase trial tests whether matching drug combinations to a patient's tumor characteristics can better control metastatic colorectal cancer. Researchers will use blood draws, biopsies, and imaging to track how tumors resist treatment. The study enrolls 100 adults with me…

This early-phase study tests two drugs together—navlimetostat and pumitamig—in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP-deficient). The main goal is to find a safe dose and see if the combination helps shrink tumors. About 17 adults…

This early-phase trial tests a virus called DNX-2401, designed to infect and destroy melanoma cells in the brain and body. About 50 adults with stage IV melanoma will receive injections to find the safest dose and number of treatments. The main goal is to check for side effects, …

This Phase 2 trial tests the drug imetelstat in 30 adults with myelodysplastic/myeloproliferative neoplasms (MDS/MPN), a rare blood cancer. The goal is to see if imetelstat can help control the disease and to check for side effects. Participants receive the drug by IV, and the st…

This phase 2 trial tests three immune-boosting drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery in 20 people with advanced but removable melanoma. The goal is to see if the combination is safe and can shrink tumors, potentially improving outcomes. Participants m…

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study compares two ways to share lung cancer screening information with people who call tobacco quitlines. Participants are quitline clients aged 50 to 80 with a heavy smoking history. One approach offers extra coaching and navigation support. The goal is to see which method…

This trial tests whether adding a brief, skills-based cognitive behavioral therapy (CBT) session to standard transitional pain care helps people recovering from surgery. Participants are adults with chronic pain or a history of substance use who take daily opioids. The study comp…

This trial tests whether an inpatient yoga therapy program can improve quality of life and reduce symptoms like nausea, fatigue, and pain in cancer patients undergoing stem cell transplantation. Participants will be randomly assigned to either the yoga program or an enhanced stan…

This early-phase trial tests whether a device that blocks signals from the vagus nerve can safely help patients with metastatic pancreatic cancer who are experiencing severe weight loss (cachexia). The device is placed on the skin over the nerve and is used alongside chemotherapy…

This study tests whether watching storytelling videos and writing or talking about personal experiences can reduce stigma and improve quality of life for women living with both cervical cancer and HIV in Zambia. Participants are randomly assigned to different combinations of stor…

This study tests if a program that delivers healthy food and teaches cooking skills is helpful for parents of children who have finished cancer treatment. The study will include 21 parents of children aged 5-12 who completed cancer therapy within the last five years. Researchers …

This trial tests a program that combines palliative care with remote monitoring and telehealth to better support people with advanced cancer. Participants complete questionnaires and physical exams, and their care is tailored to their needs. The study includes 300 adults with met…

This pilot study tests a program called COPE (Creating Opportunities for Personal Empowerment) in 40 women with stage I-III breast cancer who are starting their first treatment. Participants will either receive the 7-week COPE sessions plus standard care, or standard care alone. …

This study looks at whether inhaling isopropyl alcohol (rubbing alcohol) can help reduce nausea in cancer patients. About 112 adults with cancer who rate their nausea as at least 4 out of 10 will be asked to inhale the alcohol and report any changes. The goal is to find a quick, …

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

Researchers at MD Anderson Cancer Center want to know if the Apple Vision Pro headset can be used during image-guided procedures. Adults scheduled for a CT-guided biopsy of the abdomen or pelvis wear the headset while the operator performs the biopsy. The study measures whether t…

Researchers are testing whether a PET scan that highlights CD8 immune cells can show the best place to collect tumor-infiltrating lymphocytes (TILs) from patients with advanced melanoma. Participants receive standard TIL therapy and also undergo an extra tumor sample from the sit…

This study looks at how cancer care is provided in oncology and supportive care clinics. Researchers will collect feedback from 200 adults with advanced solid tumors to better understand and improve care delivery. The goal is to help doctors learn from patient experiences, not to…

Researchers at M.D. Anderson Cancer Center are building a large collection of biological samples and clinical data from people with urothelial carcinoma, a common type of bladder cancer, and related urinary tract cancers. The study will enroll up to 50,000 adults with known or su…

This study tests a program to help people with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. Researchers will interview 80 female participants and provide standard care to see if this approach improves adherence and…

This early-stage study tests whether a magnetic tracer and a fluorescent dye can safely help doctors find lymph nodes where stomach cancer may have spread. About 20 adults with early stomach cancer will receive the injection before surgery. The goal is to see if this method is sa…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers will interview 40 men to learn about their experiences and …

This study tests whether a chatbot called CoCo can help people understand what they're agreeing to when they join a clinical trial. Researchers want to see if using the chatbot is practical and if it improves comprehension and satisfaction compared to standard remote consent meth…

This study aims to develop an online educational tool for women diagnosed with endometrial cancer. Participants will use a website to access educational content, complete surveys, and provide feedback on its usability. The goal is to create a resource that can be made widely avai…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This study looks at whether audio recording a clinic visit helps advanced cancer patients remember what their doctor said and share it with family. About 200 patients at MD Anderson Cancer Center will be asked to record part of their visit and later report if it was useful. The g…

This phase 2 trial is testing whether blood tests and imaging scans can tell if chemotherapy is working in people with early-stage triple-negative breast cancer before they go to surgery. The study will enroll 200 participants who will receive a combination of chemotherapy drugs …

This study follows 250 gynecologic cancer patients and their informal caregivers over 6 months. Researchers will use surveys to track caregiver distress and unmet needs. The goal is to understand what caregivers go through and find ways to better support them.

This study interviews 20 pancreatic cancer patients to learn why certain groups—like racial minorities, low-income individuals, or rural residents—are less likely to join clinical trials. Researchers hope to find ways to make trials more accessible and fair for everyone. The stud…

This study will test whether intermittent fasting (eating only during an 8-hour window each day) is safe and doable for 20 people at high risk for pancreatic cancer. Researchers will also check if this eating pattern changes certain markers in the body linked to cancer risk. The …

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study looks at what helps or hinders prostate cancer patients from completing genetic testing. Researchers will develop and test a decision support tool to educate patients and help them decide about testing. The goal is to increase testing rates, which can guide treatment a…