Irccs San Raffaele

This study tests a very precise type of radiation (SBRT) for people with kidney cancer who cannot have surgery. The goal is to see if this treatment can control the tumor while causing fewer side effects. About 60 participants will be followed for three years to check for tumor c…

This study tests a new way to give radiation therapy before surgery for locally advanced rectal cancer. The goal is to increase the number of patients whose tumors completely disappear after treatment from 41% to 70%. Researchers will use a special index (ERI_TCP) to select patie…

This study compares a special ureteral access sheath with built-in suction (FANS) to the standard sheath used during kidney stone removal surgery. About 134 adults with kidney stones at least 5 mm wide will be randomly assigned to one of the two devices. The goal is to see if the…

This study looks at whether a type of PET scan called [18F]FET PET can help doctors tell the difference between a brain tumor coming back and changes caused by previous treatments like radiation. Researchers will review past scans from 69 adults with brain tumors. The goal is to …

This study will test whether a machine learning tool (ONIRY system) can detect obstetric anal sphincter injuries (OASI) in first-time mothers after vaginal birth better than the standard digital rectal exam. About 110 women will be checked with both methods within an hour of deli…

This study tests a new, high-resolution PET-CT scan done during prostate cancer surgery. The goal is to see if it can accurately find any cancer left behind or spread to nearby lymph nodes, helping surgeons remove it all. Ten men with high-risk prostate cancer will get the scan r…

This study tests two new CT scan methods to find dangerous blockages in heart arteries without needing invasive procedures. About 142 adults with moderate artery narrowing will get advanced scans to see if these techniques can accurately identify which blockages reduce blood flow…

This study tests whether a high-calorie, high-protein nutritional drink with added immune-supporting ingredients can lower the risk of serious side effects in people with advanced gastrointestinal cancers receiving their first systemic treatment. About 88 participants will be ran…

This study tests a device called VTone that uses gentle electrical pulses inside the vagina to strengthen pelvic muscles. It is for women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). 15 women will receive 8 weekly treatments and be foll…

This study tests whether a low-heat (45-50°C) vaginal radiofrequency device can calm overactive bladder by targeting nerve endings in the bladder muscle. About 48 adults with moderate-to-severe urgency incontinence will receive the office-based treatment. The goal is to reduce bo…

This study will follow 500 cancer patients starting or already on immunotherapy to better understand immune-related side effects (irAEs). Researchers will collect data on symptoms, lab tests, and treatments to find patterns that predict who gets side effects and how to manage the…

This study watches 50 people with neuromyelitis optica spectrum disorder (NMOSD) who seem stable on rituximab. Researchers use blood tests and MRI scans to find hidden signs of nerve damage that might predict future relapses or disability. The goal is to better understand the dis…

This study will measure how the antibiotic delafloxacin spreads into the blood and different body tissues of 20 adults with serious bacterial infections, including wound infections after heart surgery and infected joint replacements. Participants will continue their prescribed tr…

This lab study uses blood samples from 100 healthy volunteers to test different machine settings for a type of eye surgery called vitrectomy. The goal is to find settings that cause the least damage to cells, which could help doctors get better samples for diagnosing eye lymphoma…

This study looks at two ways to rebuild a breast after cancer surgery: one where the implant is placed right away, and another where a temporary expander is used first. Researchers will compare how often the implant is lost within 3 months, as well as other complications. The goa…

This study will track 2,500 adults in Italy who are having an endoscopic ultrasound (EUS) because doctors suspect they have pancreatic or bile duct cancer. Researchers want to see how accurate the tissue samples taken during EUS are, how safe the procedure is, and how quickly pat…

This study looks at whether a special ultrasound score (OTUS) can track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation in large arteries. About 100 adults with active disease will have regular ultrasounds during routine care. The goa…

This study tests a new AI method to generate one type of brain scan (FDG PET) from another (amyloid PET) using existing data from 35 Alzheimer's patients. If successful, future patients might need only one scan instead of two, reducing radiation, cost, and time. No new procedures…

This study looks at whether combining simple tests—like handgrip strength, body composition analysis, and thigh ultrasound—can help doctors spot rapid muscle loss (acute sarcopenia) in older adults admitted to the hospital. Researchers will follow 280 patients aged 65 and older t…

This study looks at tumor samples from 55 women with early-stage breast cancer (triple-negative or high-risk luminal) before, during, and after standard chemo-immunotherapy. Using single-cell RNA sequencing and imaging, researchers aim to identify early signs of treatment respons…

This study uses small wearable sensors to measure how people with walking problems move differently from healthy people. Researchers will compare 50 patients with gait disorders and 50 healthy volunteers. The goal is to better understand walking differences, not to test a treatme…

This study looks at 200 people with inherited retinal diseases like retinitis pigmentosa and Stargardt disease. Researchers will review past eye exams and genetic tests to understand how these diseases progress over time. The goal is to find better ways to measure vision loss, wh…

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver. Researchers will track things like blood sugar, weight, and lab results over at least 10 years to find better ways to …

This study will see if combining two types of scans (PET and MRI) can more accurately tell if a brain tumor is growing or if changes are just from treatment. Researchers will look at 270 adults with brain tumors, using scans already part of their regular care. The goal is to impr…

This observational study will follow 40 adults with thymus gland issues or myasthenia gravis (MG) antibodies to better understand how the disease starts and progresses. Researchers will analyze blood, thymus tissue, and muscle samples, along with regular check-ups over 18 months.…

This study will test a new wide field OCTA device in 200 adults with various eye diseases like age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device provides better images of blood vessels in the back and front of the eye compared …

This study will check if a special ultrasound technique can accurately measure disease activity in people with moderate-to-severe ulcerative colitis. About 25 adults starting a new medication will be followed for 24 weeks. The goal is to see if ultrasound can replace the need for…

This study follows 330 children born after IVF with genetic testing to see if the embryo biopsy affects their growth at one year old. Researchers will compare these children to those born without the biopsy. The goal is to better understand the long-term safety of this common pro…

This study aims to develop a safer, cheaper way to monitor Alzheimer's treatment using advanced MRI scans and blood tests instead of repeated PET scans. Researchers will track 50 people with early Alzheimer's who are receiving antibody therapy (lecanemab or donanemab) to build pe…

This study looks at eating behaviors in teens aged 11-17 with celiac disease compared to healthy teens. About 300 participants will fill out questionnaires about their eating habits and concerns. A smaller group newly diagnosed with celiac disease will be followed for two years t…

This study will collect and analyze brain scans and medical records from over 1,100 adults with cerebrovascular disease (conditions affecting blood vessels in the brain). The goal is to better understand how different types of brain damage seen on MRI or CT scans relate to patien…