Irccs San Raffaele

This study aimed to see if giving the immunotherapy drug pembrolizumab before radical prostatectomy could reduce lymph node invasion in high-risk prostate cancer patients. Participants would have received three doses of the drug before surgery. However, the study was withdrawn be…

This study looks at whether giving long-acting HIV injections at home is as practical and acceptable as giving them in the hospital. About 120 adults with well-controlled HIV will receive the shots either at home or in the hospital. Researchers will measure how easy and appropria…

This study reviews medical records of 36 adults with relapsed or refractory primary central nervous system lymphoma (PCNSL) who were treated with ibrutinib alone or with R-CHOP chemo. The goal is to see how many patients respond to treatment. PCNSL is a rare and aggressive brain …

Researchers compare two types of CT scanners for imaging heart arteries in people with suspected chronic coronary syndrome. One scanner uses standard energy-integrating detectors, while the other uses newer photon-counting detectors that may produce clearer pictures with fewer fa…

This study tests whether adding a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to speech therapy can improve language skills in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. A…

Researchers are testing a muscle biopsy method that uses mild electrical stimulation to sample the junction where nerves meet muscle. The goal is to see if this technique helps distinguish between inclusion body myositis and motor neuron disease, which can look alike. The study i…

This study investigates whether a combination of brain MRI scans, sleep recordings, and cognitive tests can track early brain changes in people with idiopathic REM sleep behavior disorder (iRBD), a condition that often precedes Parkinson's disease. Researchers will follow 50 peop…

This study looks at how consistently doctors can identify paramagnetic rim lesions (PRLs) on MRI scans of people with multiple sclerosis. PRLs are a sign of more active and aggressive disease. By having experts from 15 centers review the same scans, the researchers aim to create …

This study looks back at medical records of 500 adults with aggressive B-cell lymphoma that has a MYC gene change. Researchers want to see if a stronger chemotherapy plan called CARMEN leads to better survival and remission rates compared to other treatments. Since it's a review …

This study looks at whether taking a small sample from an embryo (blastocyst biopsy) for genetic testing affects a child's growth in the first year of life. Researchers will compare children born after this procedure to those born without it. Parents will fill out a questionnaire…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study aims to understand why kidney tumors in people with VHL syndrome can be different from each other. Researchers will use advanced imaging, multiple biopsies, and lab-grown tumor models to map these differences. The goal is to learn more about the disease, not to test a …

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…

This study aims to create a questionnaire that measures how patients feel about their experience during endoscopic ultrasound, a procedure used to examine the pancreas and bile ducts. Researchers will ask 171 outpatients at a hospital in Italy to rate their experience, and compar…

This study looks at people with trigeminal neuralgia, a condition that causes severe facial pain. Researchers want to see if adding virtual reality (VR) training before Gamma Knife surgery can improve pain relief. They will also use artificial intelligence (AI) and brain scans to…

This study is collecting information from 200 patients who had a type of aortic dissection (a tear in the main artery) and were treated with a procedure called STABILISE. The goal is to see how well the technique works and what complications may occur. Participants are adults wit…

This study looks at a specific DNA repair issue called homologous recombination deficiency (HRD) in people with a type of lung cancer (EGFR-mutated NSCLC). Researchers want to know how common HRD is and whether it relates to how the cancer behaves. They will also test this in lab…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …

This study uses machine learning to analyze data from 5,000 IVF patients to identify patterns that predict successful pregnancy. Researchers hope to create a tool that helps doctors personalize treatments, improving success rates and reducing the emotional and financial burden on…

This study looks at whether faster ways to thaw frozen eggs (rapid and ultra-rapid) work better than the standard method. Researchers will check how many eggs survive and how healthy they look after thawing. The study uses eggs donated for research from 399 women aged 20-39.