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Could a new mouthwash formula be kinder to your gums?

NCT ID NCT07669636

Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This lab study tests whether adding N-acetylcysteine and hyaluronic acid to a standard chlorhexidine mouthwash can reduce harm to gum cells. Researchers will grow human gum cells from discarded dental tissue and expose them to different mouthwash strengths. They will measure cell survival, movement, and gene activity to see if the new formula is less toxic.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chlorhexidine mouthwash with N-acetylcysteine and hyaluronic acid
What this could lead to
If successful, this could point toward a gentler mouthwash that kills germs without damaging gum tissue.
What could go wrong
This is a very early lab study with only 3 samples, not in humans. Results may not translate to real mouths, and the added ingredients might not improve safety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of three healthy adult donors undergoing routine dental surgical procedures at the Dental Unit of San Raffaele Hospital. Small fragments of discarded gingival tissue obtained during procedures such as tooth extraction or gingivectomy will be collected following informed consent. Human gingival fibroblasts will be isolated from these tissues and expanded in culture for in vitro experimental analyses.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female adults aged 18 years or older. * Undergoing routine dental surgical procedures (e.g., tooth extraction or gingivectomy). * Willing and able to provide written informed consent for the use of discarded gingival tissue for research purposes. * Systemically healthy. Exclusion Criteria: * Presence of systemic diseases. * Presence of relevant medical comorbidities. * Current smoker. * Refusal to provide informed consent for the use of discarded biological material.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biocompatibility Chlorhexidine Cytotoxicity Fibroblast HGF

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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