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Toothpaste ingredient may alter Mouth's germ balance

NCT ID NCT07570927

Knowledge-focused Sponsor: Masaryk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a low-dose chlorhexidine toothpaste on 11 healthy adults to see how it changes the types and functions of bacteria in their saliva. Participants used the toothpaste twice daily for 12 weeks, and researchers compared their mouth bacteria before, during, and after use. The goal was to learn about shifts in bacterial diversity and any increase in antibiotic resistance genes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.06% chlorhexidine digluconate toothpaste
What this could lead to
If successful, this could help understand how everyday toothpaste ingredients affect the balance of mouth bacteria and the spread of antibiotic resistance.
What could go wrong
This is a very small study with only 11 healthy adults, so results may not apply to everyone. It only looks at short-term effects and doesn't test for long-term health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

11 people

The number who actually took part.

Started

Apr 2022

Finished

Nov 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 44 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: Between 25-44 years. * General Health: Good systemic health (absence of chronic inflammatory diseases or conditions affecting oral tissues). * Oral Hygiene Routine: Participants must perform toothbrushing twice a day and use interdental cleaning aids once a day. * Plaque Index (PI): A score of 0.0-0.2 according to Silness and Löe. * Gingival Index (GI): A score of 0.0-0.143 according to Silness and Löe. Exclusion Criteria: Systemic and Lifestyle Factors: * Presence of any chronic systemic disease (e.g., diabetes mellitus, autoimmune disorders) * Regular use of medications that may affect gingival status or saliva production. * Use of antibiotics within the last 6 months prior to the study. * Current pregnancy or lactation. * Current smokers or users of other tobacco/nicotine products. Oral and Dental Factors: * Active dental disease: Presence of untreated tooth decay, gingivitis (GI \> 0.143), or any form of periodontitis. * Prosthetics and Implants: Presence of dental implants, dentures, or significant tooth loss (excluding extracted third molars). * Ongoing fixed or removable orthodontic treatment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antimicrobial resistance (AMR) Chlorhexidine Oral microbiome health Oral microbiota Saliva microbiome

Contacts and locations

Locations

  • Department of Public Health, Faculty of Medicine, Masaryk University

    Brno, 62500, Czechia

  • Skydent s.r.o.

    Brno, 62500, Czechia

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