Toothpaste ingredient may alter Mouth's germ balance

NCT ID NCT07570927

Completed Knowledge-focused Sponsor: Masaryk University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a low-dose chlorhexidine toothpaste on 11 healthy adults to see how it changes the types and functions of bacteria in their saliva. Participants used the toothpaste twice daily for 12 weeks, and researchers compared their mouth bacteria before, during, and after use. The goal was to learn about shifts in bacterial diversity and any increase in antibiotic resistance genes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 0.06% chlorhexidine digluconate toothpaste
What this could lead to: If successful, this could help understand how everyday toothpaste ingredients affect the balance of mouth bacteria and the spread of antibiotic resistance.
What could go wrong: This is a very small study with only 11 healthy adults, so results may not apply to everyone. It only looks at short-term effects and doesn't test for long-term health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIMICROBIAL RESISTANCE (AMR) CHLORHEXIDINE ORAL MICROBIOME HEALTH ORAL MICROBIOTA SALIVA MICROBIOME

Contacts and locations

Locations

Department of Public Health, Faculty of Medicine, Masaryk University

Brno, 62500, Czechia
Skydent s.r.o.

Brno, 62500, Czechia

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