Irccs San Raffaele

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It includes 311 participants aged 40 and older with favorable tumor types. The goal is to see if the one-time treatment controls cancer just…

This study tests a combination of ibuprofen, G-CSF, and plerixafor to collect stem cells from people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. The goal is to see if this drug mix is safe and effective at gathering enough stem cells for future ge…

This study compares a new type of CT scanner (photon-counting CT) to MRI for finding liver tumors that have spread from colorectal cancer. About 100 adults with colorectal cancer will get both scans, and researchers will check if the new CT is as good as MRI at spotting these tum…

This study is checking if a blood test for a protein called S100B can tell doctors whether a patient with a head injury has a brain injury or not. The test is very good at ruling out brain injury, which could help avoid unnecessary CT scans and long waits in the emergency room. A…

This study tests whether combining two types of scans (PET and MRI) before a prostate biopsy can more accurately find serious prostate cancers while avoiding unnecessary biopsies for low-risk cancers. About 167 men with suspected prostate cancer will receive the combined scan, an…

This study is testing a new digital platform that uses simple, non-invasive tools like EEG, eye-tracking, and blood flow sensors to find early signs of Alzheimer's disease. It will include 100 people aged 55 to 80, some with mild memory problems and some healthy. The goal is to c…

This study tests whether a 3-week home program using virtual reality and action observation can improve hand dexterity in people with multiple sclerosis. 60 participants will either watch and imitate hand tasks in VR or watch landscapes before doing the same tasks. The goal is to…

This study tests whether adding gentle electrical stimulation to the brain and spine can improve walking and balance in people with Parkinson's disease who have trouble with falls and movement. About 71 people (51 with Parkinson's and 20 healthy volunteers) will take part. Partic…

This study tests whether virtual reality-based exercises can reduce neck pain and improve daily activities in people with chronic neck pain or whiplash. Seventy-two adults will be randomly assigned to either VR-enhanced rehabilitation or the same exercises without VR. The goal is…

This study looks at how pancreatic cancer changes over time in patients receiving chemotherapy. Researchers will take small tissue samples from the tumor before and after treatment to see if the cancer's molecular subtype shifts. The goal is to better understand how the cancer ad…

This study is a registry that will collect medical information from up to 10,000 people with esophageal problems like GERD, achalasia, and other swallowing disorders. Researchers will gather data from standard tests to better understand these conditions. The goal is to improve di…

This study looks at how genes and certain body chemicals may be linked to Menière's disease, a condition that causes severe dizziness and hearing problems. Researchers will compare 250 people with Menière's disease to those with vestibular migraine and healthy individuals. The go…

This study is a registry that collects information from 100 people with deep vein disease in the legs. Researchers will track treatments and outcomes for up to 10 years to learn which approaches work best. The goal is to help doctors make better decisions for future patients.

This study looks at how often men over 50 have undetected spine fractures by using artificial intelligence to analyze CT scans done for other medical reasons. The goal is to find fractures linked to osteoporosis early, without extra tests or radiation. Researchers will enroll 250…

This study is looking for 50 adults with small kidney tumors (up to 4 cm) who are scheduled for surgery. Researchers want to see if combining MRI scans with detailed analysis of tumor tissue (biopsies) can better predict which tumors are aggressive. The goal is to improve how doc…

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three standard procedures to see which one helps patients eat better, tolerate chemotherapy, and maintain nutrition. Participants fill out quality-of-life questionnaires but r…

This study looks at how factors like age, sex, and tumor grade influence how well treatments work for a type of rare gut cancer called GEP-NENs. Researchers will follow 450 adults with well-differentiated tumors who are receiving standard therapies such as somatostatin analogs or…

This study will use advanced CT scans to look at both the lungs and heart in 123 adults with interstitial lung disease (ILD). The goal is to find better ways to detect and measure lung damage and hidden heart problems early. Researchers hope this will help doctors predict and man…

This study is creating a registry of 100 women who have had a heart attack (acute coronary syndrome). Researchers will collect genetic, biochemical, and molecular information to better understand how heart attacks differ among women. The goal is to identify subtypes that could le…

This study aims to create a large national collection of genetic and medical data from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze participants' complete DNA to find rare genetic changes that may cause or influence the disease. They w…

This study looks at medical records from 1000 adults to understand how bones, muscles, and energy use are linked. Researchers will analyze blood and urine tests for markers like osteocalcin and vitamin D. The goal is to see how these markers change with age and sex, and to build …

This study asks 144 people with advanced lung cancer to fill out online questionnaires about their quality of life, symptoms, mood, sleep, and more. The goal is to see how these patient reports relate to treatment success and survival. No new treatment is tested; instead, researc…

This study is creating a massive collection of medical images (CT and MRI scans) and health information from 50,000 adults. Researchers will use this data to find hidden patterns in images that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain…

This study looks at whether CT scans can be used to check heart tissue health, similar to how MRI does now. MRI is the current best method but has limits—it can't be used in people with certain devices, takes a long time, and can't see the heart's arteries. CT scans are faster an…

This study is looking for new ways to tell which pancreatic cysts (called IPMNs) are cancerous and which are harmless. Right now, many people have surgery to remove cysts that turn out to be benign, which can lead to complications. Researchers will study blood, fluid, and tissue …

This study is testing a gel called PuraBond that helps stop bleeding during open surgery on the main artery in the belly. About 100 adults having this surgery will be watched to see how quickly the gel works. The goal is to learn if PuraBond can make surgery safer and faster.

This study is looking for better ways to diagnose endometriosis and adenomyosis, two conditions that can cause pain and fertility problems. Researchers will collect blood and fluid samples from 530 women, including those with these conditions and those seeking fertility treatment…

This study is gathering detailed information from 625 people with colorectal or pancreatic cancer that has spread to the liver, as well as from healthy volunteers. Researchers will analyze tumor and blood samples to understand how the immune system interacts with these cancers. T…

This study will follow 1000 adults with low vitamin D who are taking supplements. Researchers will collect health data over 10 years to see how vitamin D use relates to conditions like heart disease, diabetes, cancer, and osteoporosis. The goal is to learn more about risk factors…

This study looks at whether ultrasound can detect scarring (fibrosis) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from colonoscopies to develop new, non-invasive ways to measure disease. The goal is to improve diagn…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, or bone infections. Researchers will track their symptoms, lab results, and treatments over time, and store biological samples for future research. The goal i…