Institut Claudius Regaud

This study tests whether adding 4 cycles of chemotherapy around the time of surgery can help prevent the spread of soft tissue sarcoma in people whose tumors are considered high-risk based on a genetic test. About 600 adults with resectable sarcoma will be screened, and 250 high-…

This study tests whether adding focused radiation to standard treatment helps people with metastatic bladder cancer live longer. It includes patients whose cancer has not worsened after initial therapy and who have three or fewer remaining tumors. The goal is to see if zapping th…

This study looks at whether surgically removing para-aortic lymph nodes before standard chemoradiation can help people with stage IIIC1 cervical cancer live longer without the disease coming back. About 510 participants will be randomly assigned to either standard treatment or su…

This study tests whether giving only 4 cycles of chemotherapy (instead of the usual 6) alongside the immunotherapy drug pembrolizumab is safe and effective for people with PD-L1-positive head and neck cancer that has come back or spread. About 86 participants will receive the sho…

This study looks at whether medical hypnosis, combined with relaxing music, can reduce anxiety in cancer patients who are moderately to very anxious during their radiation treatments. About 45 adults with solid tumors will be randomly assigned to either listen to music alone or l…

This study tests whether a personalized pre-surgery program—including physical therapy, nutrition, and exercise—helps people with bone or soft-tissue sarcoma of the arm or leg recover better after tumor removal. About 53 participants will be followed for up to 24 months after sur…

This study tests a new surgical technique using a skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if this method causes fewer complications at the donor site compared to standard flaps. About 40 adults with head and neck cance…

This study aims to understand why some breast cancers with BRCA mutations become resistant to PARP inhibitor drugs. Researchers will collect tumor and blood samples from 120 people with advanced HER2-negative breast cancer to measure certain proteins linked to DNA repair. The goa…

This study looks at immune cells (T cells) in tumor samples from 1,100 people with cancers like head and neck, ovarian, cervical, lung, and brain cancer. Researchers want to understand how these cells behave, especially a protein called PD-1. No new treatments are tested—only sam…

This study is not testing a new treatment. Instead, it collects blood and tumor samples from 80 people with newly diagnosed glioblastoma who are already receiving standard care plus TTFields (a device that uses electric fields to slow cancer growth). Researchers will analyze thes…

This study looks at how body weight (BMI) influences the amount of the drug Trastuzumab-Deruxtecan (T-DXd) in the blood and its side effects in people with advanced breast cancer. Researchers will compare normal-weight and overweight/obese patients to see if drug exposure differs…

This study looks at whether a blood test (liquid biopsy) can detect prostate cancer cells as well as a special PET scan. Researchers will compare results from 80 patients to see if the blood test can show how far the cancer has spread. The goal is to find a less invasive way to m…

This study explores whether using alternative or complementary therapies (like turmeric supplements) impacts how consistently patients take tamoxifen, a key hormone therapy for early-stage breast cancer. Researchers will follow 200 patients for one day to measure adherence and ta…

This study follows 150 people with a GATA2 gene mutation over 5 years to find early warning signs of blood cancers like MDS and AML. Researchers will collect blood and bone marrow samples during routine care to track changes. The goal is to better predict who might develop seriou…

This study looks at families who carry a specific gene change (DDX41) that may increase the risk of blood cancers. Researchers will track how many family members develop blood problems over time. The goal is to better understand the risk and create guidelines for doctors. No new …

This study looks at whether a blood test can find changes in the BRCA gene that might signal ovarian cancer is coming back earlier than usual scans. About 130 women with BRCA-mutated ovarian cancer who are starting maintenance therapy with a PARP inhibitor will give blood samples…

This study aims to find biological markers in blood and tumor samples that predict how well immunotherapy works and what side effects may occur. It will enroll 770 adults with advanced solid cancers like lung, head and neck, melanoma, or bladder cancer who are receiving immune ch…

This study aims to understand why some ovarian cancers become resistant to platinum-based chemotherapy. Researchers will follow 600 patients for 5 years, collecting medical data and biological samples (blood, tumor, and fluid samples) during standard care. No extra procedures are…

This study aims to learn more about the immune system's role in rare types of sarcoma, a group of cancers. Researchers will collect medical information and tissue samples from 500 patients with these rare sarcomas. The goal is to find patterns that could lead to better treatments…

This study aims to create a detailed map of the tiny structures inside breast cancer cells, such as fat droplets and other organelles, across different cancer subtypes. Researchers will collect tissue samples from 1,050 people with early or metastatic breast cancer and analyze th…

This study looks at whether a score based on two common blood markers (CRP and albumin) can predict if a patient's tumor will shrink or stop growing after Lu-177 treatment. About 150 adults with advanced intestinal neuroendocrine tumors will be followed for 3 years. The goal is t…

This study follows 130 children who had radiation for a brain tumor between ages 4 and 12. Researchers will test their memory and attention 2 and 4 years after treatment, and also look at brain scans to see how radiation doses to the hippocampus relate to memory problems. The goa…