Institut Claudius Regaud

This study looked at a treatment plan for women with invasive breast cancer that involves removing the breast (mastectomy) and immediately rebuilding it with an implant, followed by radiation therapy (sometimes with chemotherapy). The goal was to see how often this approach works…

This early-phase trial tested a new drug called cilengitide alongside standard chemotherapy and radiation for people with advanced non-small cell lung cancer that cannot be surgically removed. The main goal was to find the safest dose of cilengitide when given continuously. Fourt…

This study tested a surgery called nipple-sparing mastectomy for people with breast cancer. The goal was to see if removing the breast tissue but keeping the nipple and skin is safe and leads to low cancer return rates. 450 participants were followed for 5 years after surgery. Th…

This study tested the drug sunitinib in 21 people with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors. Sunitinib works by blocking blood flow to cancer cells and stopping them from growing. The study was completed and looked …

This study tested whether a combination of two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spread cancer received the drug combo. The goal was to see how many patients respon…

This study tested a two-step high-dose chemotherapy plan in 101 people with germ cell tumors that came back or didn't respond to standard treatment. The approach used paclitaxel and ifosfamide first, then carboplatin and etoposide, with carboplatin doses adjusted for each patient…

This early-phase study tested whether adding a TNF-blocker (infliximab or certolizumab) to standard immunotherapy (nivolumab + ipilimumab) is safe for people with advanced melanoma that has spread or cannot be removed. 33 adults aged 18–70 took part. The main goal was to find the…

This study tested a precise radiation technique for men with low-risk prostate cancer. 18 men received a permanent radioactive implant only in the tumor area. The main goal was to see if the planned radiation dose could be delivered accurately. This approach aims to control the c…

This study tested whether adding an immunotherapy drug (durvalumab) to focused radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer that has come back after initial treatment. The trial involved 108 adults and first checked safety, then random…

This early-stage study tested a type of radiation therapy called PRRT in one child with neuroblastoma that had come back or not responded to standard treatments. The therapy uses a radioactive drug that targets tumor cells. The main goal was to find the safest dose and monitor si…

This study looked at whether measuring drug levels in the blood and adjusting doses accordingly can improve treatment for advanced kidney cancer. 47 patients taking sunitinib or pazopanib were followed to see if this approach reduced side effects and delayed cancer progression. T…

This study tested how well two different PET-CT scanners can find very small cancer spots (less than 1 cm) in 24 cancer patients. Patients were grouped by body size (BMI). Each person had two scans, and doctors reviewed the images to see which scanner detected more tiny lesions. …

This study looked at whether a special PET scan tracer called F-DOPA can better detect leftover medullary thyroid cancer in lymph nodes after surgery compared to standard scans. Twenty-four adults with high thyrocalcitonin levels after thyroid removal took part. The goal was to s…

This study tested whether a capsaicin patch (Qutenza) applied to the neck and face can reduce nerve pain better than a standard medication (amitriptyline) in people who finished treatment for head and neck cancer. The trial aimed to enroll 130 participants but only 13 took part. …

This study involved 60 people with advanced melanoma who were already scheduled to receive immunotherapy drugs (either a single drug or a combination). Researchers collected blood samples and, when possible, tumor samples before and during treatment to look for markers that might…

This study looked at 39 women with advanced breast cancer who were starting hormone therapy (tamoxifen or aromatase inhibitors). Researchers checked their blood for tiny molecules called microRNAs that might show whether the cancer is sensitive or resistant to the treatment. The …

This study looked at whether it is possible to measure certain cholesterol byproducts, called oxysterols, in the blood of women with breast cancer who are taking hormone therapy like tamoxifen. The study included 29 women and took blood samples before and 28 days after starting t…

This study looked at whether the body's natural 24-hour cycle (circadian rhythm) affects how lung cancer cells spread through the blood. Researchers took blood samples from 27 people with advanced lung cancer before they started treatment. The goal was to see if the number of cir…

This study involved 267 women with metastatic breast cancer who were starting a third round of chemotherapy. Researchers created a scoring system using clinical, lab, and tumor cell data to predict which patients would live longer with this treatment. The goal is to help doctors …

This study looked at how the anti-nausea medication aprepitant changes the amount of the chemotherapy drug ifosfamide in the blood of people with soft tissue sarcoma. 59 patients receiving doxorubicin and ifosfamide were followed for two treatment cycles. The goal was to see if a…

This study followed 150 adults with solid tumors who were starting a type of immunotherapy called immune checkpoint inhibitors. Researchers collected data on side effects during each treatment session and asked patients to fill out questionnaires. The goal was to better understan…

This study looked at 2000 women with hormone-sensitive breast cancer who were taking hormone therapy after surgery. The goal was to see how a person's genetics and the amount of drug in their blood are related. Researchers tracked these factors over the first 3 years of treatment…

This study looked at whether a special MRI technique can identify the most aggressive parts of a glioblastoma brain tumor. Researchers took tissue samples from different areas of the tumor during surgery and tested them for cancer stem cells. The goal was to see if MRI markers ma…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per quality-adjusted life year (QALY) over three years in 200 women with advanced ovarian cancer. The goal was to see if sticking to guidelines p…

This study tested whether a special 'return home' consultation, involving the patient, their regular doctor, and a cancer specialist, could reduce unplanned hospital visits for people with metastatic cancer. 667 hospitalized patients were randomly assigned to either this organize…

This study looked at 60 people with metastatic breast cancer to find out if certain cells in their blood (called CK+/CD45+ double-positive cells) come from the tumor. Researchers took a blood sample before starting treatment and checked archived tumor samples. The goal was to bet…

This study looked at 60 people with a type of blood cancer called diffuse large B-cell lymphoma. Researchers used advanced techniques to examine individual cells from tumors and blood samples. The goal was to find markers that could help track how the disease changes over time an…